Acknowledgement
We thank Mectron spa, Italy, for providing the material for the present study.
References
- Abusleme L, Hoare A, Hong BY, Diaz PI: Microbial signatures of health, gingivitis, and periodontitis. Periodontol 2000 86: 57-78, 2021. https://doi.org/10.1111/prd.12362
- Haas AN, Furlaneto F, Gaio EJ, et al.: New tendencies in non-surgical periodontal therapy. Braz Oral Res 35(Supp 2): e095, 2021. https://doi.org/10.1590/1807-3107bor-2021.vol35.0095
- Graziani F, Cei S, Orlandi M, et al.: Acute-phase response following full-mouth versus quadrant non-surgical periodontal treatment: a randomized clinical trial. J Clin Periodontol 42: 843-852, 2015. https://doi.org/10.1111/jcpe.12451
- Quirynen M, De Soete M, Boschmans G, et al.: Benefit of "one-stage full-mouth disinfection" is explained by disinfection and root planing within 24 hours: a randomized controlled trial. J Clin Periodontol 33: 639-647, 2006. https://doi.org/10.1111/j.1600-051X.2006.00959.x
- Van der Weijden GAF, Dekkers GJ, Slot DE: Success of non-surgical periodontal therapy in adult periodontitis patients: a retrospective analysis. Int J Dent Hyg 17: 309-317, 2019. https://doi.org/10.1111/idh.12399
- Cobb CM: Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing. J Clin Periodontol 29 Suppl 2: 6-16, 2002. https://doi.org/10.1034/J.1600-051X.29.S2.4.X
- Brookes ZLS, Belfield LA, Ashworth A, et al.: Effects of chlorhexidine mouthwash on the oral microbiome. J Dent 113: 103768, 2021. https://doi.org/10.1016/j.jdent.2021.103768
- Palma LF, Joia C, Chambrone L: Effects of ozone therapy on periodontal and peri-implant surgical wound healing: a systematic review. Quintessence Int 54: 100-110, 2023. https://doi.org/10.3290/j.qi.b3512007
- Deepthi R, Bilichodmath S: Ozone therapy in periodontics: a meta-analysis. Contemp Clin Dent 11: 108-115, 2020. https://doi.org/10.4103/ccd.ccd_79_19
- Premjit Y, Sruthi NU, Pandiselvam R, Kothakota A: Aqueous ozone: chemistry, physiochemical properties, microbial inactivation, factors influencing antimicrobial effectiveness, and application in food. Compr Rev Food Sci Food Saf 21: 1054-1085, 2022. https://doi.org/10.1111/1541-4337.12886
- Marconcini S, Giammarinaro E, Cosola S, Oldoini G, Genovesi A, Covani U: Effects of non-surgical periodontal treatment on reactive oxygen metabolites and glycemic control in diabetic patients with chronic periodontitis. Antioxidants (Basel) 10: 1056, 2021. https://doi.org/10.3390/antiox10071056
- Sen S, Sen S: Ozone therapy a new vista in dentistry: integrated review. Med Gas Res 10: 189-192, 2020. https://doi.org/10.4103/2045-9912.304226
- Ranjith A, Niranjana JM, Baiju KV: Adjunctive benefit of ozonized water irrigation with mechanical debridement in the management of Stage III periodontitis: a randomized controlled clinical and biochemical study. Int J Dent Hyg 20: 364-370, 2022. https://doi.org/10.1111/idh.12547
- Loe H: The Gingival Index, the Plaque Index and the retention index systems. J Periodontol 38: Suppl:610-616, 1967. https://doi.org/10.1902/jop.1967.38.6.610
- Graziani F, Karapetsa D, Alonso B, Herrera D: Nonsurgical and surgical treatment of periodontitis: how many options for one disease? Periodontol 2000 75: 152-188, 2017. https://doi.org/10.1111/prd.12201
- Sanz M, Herrera D, Kebschull M, et al.; EFP Workshop Participants and Methodological Consultants: Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline. J Clin Periodontol 47(Suppl 22): 4-60, 2020. https://doi.org/10.1111/jcpe.13290 Erratum in: J Clin Periodontol 48: 163, 2021. https://doi.org/10.1111/jcpe.13403
- Moreo G, Mucchi D, Carinci F: Efficacy ozone therapy in reducing oral infection of periodontal disease: a randomized clinical trial. J Biol Regul Homeost Agents 34(4 Suppl 1): 31-36,
- Marconcini S, Giammarinaro E, Covani U: The timeliness of ozone in the COVID era. Eur Rev Med Pharmacol Sci 24: 4625-4626, 2020. https://doi.org/10.26355/eurrev_202005_21146
- Tasdemir Z, Alkan BA, Albayrak H: Effects of ozone therapy on the early healing period of deepithelialized gingival grafts: a randomized placebo-controlled clinical trial. J Periodontol 87: 663-671, 2016. https://doi.org/10.1902/jop.2016.150217
- Kazancioglu HO, Kurklu E, Ezirganli S: Effects of ozone therapy on pain, swelling, and trismus following third molar surgery. Int J Oral Maxillofac Surg 43: 644-648, 2014. https://doi.org/10.1016/j.ijom.2013.11.006
- Moraschini V, Kischinhevsky ICC, Calasans-Maia MD, et al.: Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials. Clin Oral Investig 24: 1877-1888, 2020. https://doi.org/10.1007/s00784-020-03289-2
- Zeng J, Dou J, Gao L, et al.: Topical ozone therapy restores microbiome diversity in atopic dermatitis. Int Immunopharmacol 80: 106191, 2020. https://doi.org/10.1016/j.intimp.2020.106191