대한한의학회지 (The Journal of Korean Medicine)

  • 제44권4호
  • /
  • Pages.193-207
  • /
  • 2023
  • /
  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지
DOI QR코드

DOI QR Code

A Review of Current Clinical Research on Herbal Monotherapy for Coronavirus Disease-19 (COVID-19)

  • Jee Won Shon (Department of Pharmacology, College of Korean Medicine, Pusan National University) ;
  • Do Kyung Han (Department of Pharmacology, College of Korean Medicine, Pusan National University) ;
  • Won Gun An (Department of Pharmacology, College of Korean Medicine, Pusan National University)
  • 투고 : 2023.10.20
  • 심사 : 2023.11.11
  • 발행 : 2023.12.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: The purpose of this study was to evaluate the effectiveness and safety of traditional herbal medicine as a stand-alone treatment group through major English databases due to the lack of RCTs in Korea, and to provide a review of the herbal interventions used. Methods: Using four databases (Pubmed, EMBASE, OASIS, RISS), combination of words such as "Coronavirus" "RCT" "Herb" "Decoction" "TCM" were used. RCTs using herbal medicines to treat coronavirus were searched. Final 4 studies were selected by two authors according to inclusion and exclusion criteria. Results: A total of 1,435 patients were studied. The Chinese herbs used in the treatment group were Shengmai Yin, JingYinGuBiao granules, Jinhua Qinggan granules, and Bufei Huoxue capsules. The intervention group showed greater attenuation of pneumonia lesions on CT. Also, improvement in 6-min walk distance (6MWD), and negative conversion rate in treatment group were reported. Furthermore, scores on the Fatigue Assessment Inventory (FAI) were lower in the herbal group than in the placebo group. The median time to recovery of COVID-19 related symptoms was shorter in TCM group compared to the control group. Reported adverse effects were diarrhea, liver dysfunction, and excessive menstruation, and two papers did not mention side effects in detail. Conclusion: Herbal medicine alone can increase the conversion rate of viral negativity and relieve COVID-19 related symptoms without significant adverse effects.

키워드

과제정보

Two authors contributed equally to the study. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education under grant [No. NRF-2021R1|1A3A04037158].

참고문헌

  1. Yin, J., Li, C., Ye, C., Ruan, Z., Liang, Y., Li, Y., et al. (2022). Advances in the development of therapeutic strategies against COVID-19 and perspectives in the drug design for emerging SARS-CoV-2 variants. Comput Struct Biotechnol J, 20, 824-837. doi:10.1016/j.csbj.2022.01.026 
  2. Chaudhuri, K., Chakrabarti, A., Chandan, J.S., Bandyopadhyay, S. (2022). COVID-19 vaccine hesitancy in the UK: a longitudinal household cross-sectional study. BMC Public Health, 22(1), 1-13. doi: 10.1186/s12889-021-12472-3. 
  3. Machingaidze, S., Wiysonge, C.S. (2021). Understanding COVID-19 vaccine hesitancy. Nat Med, 27(8), 1338-1339. doi:10.1038/s41591-021-01459-7 
  4. WHO(World Health Organization). Coronavirus (COVID-19) Dashboard. https://covid19.who.int/ 
  5. NIKOM(National Institute for Korean Medicine Development). Clinical Practice Guideline of Korean Medicine for Coronavirus Disease-19. (2nd edition) 2020. Available from : URL:https://nikom.or.kr/nckm/module/practiceGuide/view.do?guide_idx=125&progress=&mds_code=&disease_code=&gubun=&code_gubun=mds&agency=&continent=&sortField=&sortType=&language=kor&country=&continent_str=&search_type=all&search_text=&viewPage=1&guide_idx=&progress_jq=&title=%EC%BD%94%EB%A1%9C%EB%82%98&disease_code_etc1=&agency_jq=&country=&cert_yn=&release_date=&menu_idx=14 
  6. Sharma, A., Tiwari, S., Deb, M.K., Marty, J.L. (2020). Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): a global pandemic and treatment strategies. Int J Antimicrob Agents, 56(2). doi:10.1016/j.ijantimicag.2020.106054 
  7. WHO(World Health Organization). WHO Expert Meeting on Evaluation of Traditional Chinese Medicine in the Treatment of COVID-19. 2022. Available from : URL: https://www.who.int/publications/m/item/whoexpert-meeting-on-evaluation-of-traditional-chinese-medicine-in-the-treatment-of-covid-19 
  8. Wang, C., Sun, S., Ding, X. (2021). The therapeutic effects of traditional chinese medicine on COVID-19: a narrative review. Int J Clin Pharm, 43(1), 35-45. doi:10.1007/S11096-020-01153-7 
  9. Jeong, S., Lee, K., Jeong, M., Song, M., Jang, I. (2021). A review on the treatment of Herbal Medicine for asymptomatically infected COVID-19 patients. J Korean Med, 42(1):99-109. DOI: https://doi.org/10.13048/jkm.21007 
  10. Chen, Y., Liu, C., Wang, T., Qi, J., Jia, X., Zeng, X., et al. (2022). Efficacy and safety of Bufei Huoxue capsules in the management of convalescent patients with COVID-19 infection: A multicentre, double-blind, and randomised controlled trial. J Ethnopharmacol, 284. doi:10.1016/j.jep.2021.114830 
  11. Chen, B., Geng, P., Shen, J., Liangpunsakul, S., Lyu, H., Zhang, J., et al. (2022). Traditional Chinese Medicine JingYinGuBiao Formula Therapy Improves the Negative Conversion Rate of SARS-CoV2 in Patients with Mild COVID-19. Int J Biol Sci, 18(15), 5641-5652. doi:10.7150/ijbs.76699 
  12. Shah, M. R., Fatima, S., Khan, S. N., Ullah, S., Himani, G., Wan, K., et al. (2022). Jinhua Qinggan Granules for Non-Hospitalized COVID-19 Patients: A Double-Blind, Placebo -Controlled, and Randomized Controlled Trial. Front Med, 9, 928468. doi: 10.3389/fmed.2022.928468 
  13. An, X., Mao, L., Xia, P., Su, W., Wang, B., Kou, L., et al. (2023). Effects of Shengmai Yin (生脉饮) on pulmonary and cardiac function in coronavirus disease 2019 convalescent patients with cardiopulmonary symptoms: a randomized, double blind, multicenter control trial. J Tradit Chin Med, 43(1), 140-145. doi:10.19852/j.cnki.jtcm.20221006.001 
  14. Huang, K., Zhang, P., Zhang, Z., Youn, J. Y., Wang, C., Zhang, H., et al. (2021). Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms. Pharmacol Ther, 225, 107843. doi:10.1016/j.pharmthera.2021.107843 
  15. Leung, P. C. (2007). The efficacy of Chinese medicine for SARS: a review of Chinese publications after the crisis. Am J Chin Med, 35(4), 575-581. doi:10.1142/S0192415X07005077 
  16. Liu, J., Manheimer, E., Shi, Y., Gluud, C. (2004). Chinese herbal medicine for severe acute respiratory syndrome: a systematic review and meta-analysis. J Altern Complement Med, 10(6), 1041-1051. doi:10.1089/ACM.2004.10.1041 
  17. An, X., Zhang, Y., Duan, L., Jin, D., Zhao, S., Zhou, R., et al. (2021). The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-19. Biomed Pharmacother, 137, 111267. doi:10.1016/J.BIOPHA.2021.111267 
  18. Zhou, P., Yang, X., Wang, X., Hu, B., Zhang, L., Zhang, W., et al. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270-273. doi:10.1038/s41586-020-2012-7 
  19. Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., et al. (2020). Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet, 395(10224), 565-574. doi:10.1016/S0140-6736(20)30251-8 
  20. Ni, L., Chen, L., Huang, X., Han, C., Xu, J., Zhang, H., et al. (2020). Combating COVID-19 with integrated traditional Chinese and Western medicine in China. Acta Pharm Sin B, 10(7), 1149-1162. doi:10.1016/j.apsb.2020.06.009 
  21. Lee, H., Han, Y.B., Ko, W., Kim, N., Kim, J., Lee, D.S., et al. (2020). The Comparison Between Various Solvents Extracts of Mahaenggamsuk-tang on The Anti-oxidative, Anti-inflammatory and Neuro-protective Effects. Kor. J. Pharmacogn, 51(3), 163-170. doi:10.22889/KJP.2020.51.3.163 
  22. Jung, J. K., Park, Y. K. (2010). Anti-allergic effect of Okbyungpoongsan-Hap-Changijasan. Kor. J. Herbology, 25(2), 55-63. 
  23. Lee, H., Kang, B., Hong, M., Lee, H. L., Choi, J. Y., Lee, J. A. (2020). Eunkyosan for the common cold: A PRISMA-compliment systematic review of randomised, controlled trials. Medicine, 99(31), E21415. doi:10.1097/MD.0000000000021415 
  24. Yu, C. (2022). A Case Report of a Patient with Long COVID Complaining of Cough and Sore throat Treated with Hyunggaeyungyo-tang and Saengmaek-san. J Korean Med, 43(3), 204-210. DOI: https://doi.org/10.13048/jkm.22041