Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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The Study on Anti-Oxidant and Anti-Inflammatory Effects of Wolbigachul-tang

월비가출탕(越婢加朮湯)의 항산화 및 항염증 효과에 대한 연구

  • Seung-Kyu Im (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Dongshin University) ;
  • Jae-Uk Sul (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Dongshin University) ;
  • Seon-Jong Kim (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Dongshin University) ;
  • Jae-Min Jeong (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Dongshin University) ;
  • Yun-Gwon Seon (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Jin-Bong Choi (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Dongshin University)
  • 임승규 (동신대학교 한의과대학 한방재활의학교실) ;
  • 설재욱 (동신대학교 한의과대학 한방재활의학교실) ;
  • 김선종 (동신대학교 한의과대학 한방재활의학교실) ;
  • 정재민 (동신대학교 한의과대학 한방재활의학교실) ;
  • 선윤권 (동신대학교 한의과대학 침구학교실) ;
  • 최진봉 (동신대학교 한의과대학 한방재활의학교실)
  • Received : 2022.12.16
  • Accepted : 2023.01.06
  • Published : 2023.01.31
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Abstract

Objectives This study was conducted to find out the antioxidant and inflammatory improvement effects of Wolbigachul-tang. Methods To evaluate the antioxidant and anti-inflammatory effects of wolbigachul-tang, the total polyphenol and flavonoid contents were measured. And radical scavenging function was measured. In addition reactive oxygen species, nitric oxide, cytokines productions were measured by treating wolbigachul-tang in the lipopolysaccharide-induced RAW264.7 cells. We also measured the gene expression of inducible nitric oxide synthase, cyclooxygenase-2, cytokines too. Results Radical scavenging experiments showed significant concentration-dependent scavenging capacity increase. The amount of reactive oxygen species, nitric oxide, cytokines production in the cell all showed a significant concentration-dependent decrease compared to the control group. The gene expression of inducible nitric oxide synthase, cyclooxygenase-2, and cytokines also showed a significant concentration-dependent decrease compared to the control group. Conclusions In conclusion, it is believed that wolbigachul-tang can be applied to various inflammatory diseases.

Keywords

References

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