Acknowledgement
This study was supported by a research grant from Gangnam Severance Hospital, Yonsei University College of Medicine. This study was supported by a faculty research grant from the Yonsei University College of Medicine for (6-2020-0109). This work was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare and Ministry of Science and ICT, Republic of Korea (grant number: HI17C1260 and HU20C0164). This research was supported by a National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2020R1F1A1072307). This work was supported by the Basic Science Research Program through the NRF, funded by the Ministry of Education (NRF-2020R1A6A3A01097969).
References
- Lee JC, Kim SJ, Hong S and Kim Y (2019) Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers. Exp Mol Med 51, 1-10 https://doi.org/10.1038/s12276-019-0250-2
- Karssemeijer EGA, Aaronson JA, Bossers WJ, Smits T, Olde Rikkert MGM and Kessels RPC (2017) Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: a meta-analysis. Ageing Res Rev 40, 75-83 https://doi.org/10.1016/j.arr.2017.09.003
- Frisoni GB, Fox NC, Jack CR, Scheltens P and Thompson PM (2010) The clinical use of structural MRI in Alzheimer disease. Nat Rev Neurol 6, 67-77 https://doi.org/10.1038/nrneurol.2009.215
- Ledig C, Schuh A, Guerrero R, Heckemann RA and Rueckert D (2018) Structural brain imaging in Alzheimer's disease and mild cognitive impairment: biomarker analysis and shared morphometry database. Sci Rep 8, 11258
- Folstein MF, Folstein SE and McHugh PR (1975) "Minimental state". J Psychiatr Res 12, 189-198 https://doi.org/10.1016/0022-3956(75)90026-6
- Chandra A, Valkimadi PE, Pagano G, Cousins O, Dervenoulas G and Politis M (2019) Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment. Hum Brain Mapp 40, 5424-5442 https://doi.org/10.1002/hbm.24782
- Auso E, Gomez-Vicente V and Esquiva G (2020) Biomarkers for Alzheimer's disease early diagnosis. J Pers Med 10, 114
- Yanez-Mo M, Siljander PRM, Andreu Z et al (2015) Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles 4, 27066
- Liew CC, Ma J, Tang HC, Zheng R and Dempsey AA (2006) The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med 147, 126-132 https://doi.org/10.1016/j.lab.2005.10.005
- Brouard S, Mansfield E, Braud C et al (2007) Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance. Proc Natl Acad Sci U S A 104, 15448-15453 https://doi.org/10.1073/pnas.0705834104
- O'Brien J, Hayder H, Zayed Y and Peng C (2018) Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol 9, 402
- Schipper HM, Maes OC, Chertkow HM and Wang E (2007) MicroRNA expression in Alzheimer blood mononuclear cells. Gene Regul Syst Bio 1, 263-274 https://doi.org/10.4137/grsb.s361
- Banfi S, Martins M, Rosa A et al (2011) Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease. PLoS One 6, e25443
- Leidinger P, Backes C, Deutscher S et al (2013) A blood based 12-miRNA signature of Alzheimer disease patients. Genome Biol 14, R78
- Ku T, Swaney J, Park JY et al (2016) Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues. Nature Biotechnol 34, 973-981 https://doi.org/10.1038/nbt.3641
- Woo J, Seo JM, Lee M et al (2020) A modified magnified analysis of proteome (MAP) method for super-resolution cell imaging that retains fluorescence. Sci Rep 10, 4186
- Lee M, Woo J, Kim DH et al (2021) A novel paper MAP method for rapid high resolution histological analysis. Sci Rep 11, 23340
- Zhao J, Zhou Y, Guo M et al (2020) MicroRNA-7: expression and function in brain physiological and pathological processes. Cell Biosci 10, 77
- Jin W, Shi J and Liu M (2019) Overexpression of miR-671-5p indicates a poor prognosis in colon cancer and accelerates proliferation, migration, and invasion of colon cancer cells. OncoTargets Ther 12, 6865-6873 https://doi.org/10.2147/OTT.S219421
- Azari H, Mousavi P, Karimi E et al (2020) The expanding role of CDR1-AS in the regulation and development of cancer and human diseases. J Cell Physiol 236, 771-790 https://doi.org/10.1002/jcp.29950
- De Strooper B and Karran E (2016) The cellular phase of Alzheimer's disease. Cell 164, 603-615 https://doi.org/10.1016/j.cell.2015.12.056
- Murphy MP, LeVine H and Lovell MA (2010) Alzheimer's disease and the amyloid-β peptide. J Alzheimer's Dis 19, 311-323 https://doi.org/10.3233/JAD-2010-1221
- Ulep MG, Saraon SK and McLea S (2018) Alzheimer disease. Nurse Pract 14, 129-135 https://doi.org/10.1016/j.nurpra.2017.10.014
- Thalhauser CJ and Komarova NL (2011) Alzheimer's disease: rapid and slow progression. J R Soc Interface 9, 119-126 https://doi.org/10.1098/rsif.2011.0134
- Zhou Y, Xu Z, Yu Y et al (2019) Comprehensive analysis of the lncRNA-associated ceRNA network identifies neuroinflammation biomarkers for Alzheimer's disease. Mol Omics 15, 459-469 https://doi.org/10.1039/c9mo00129h
- Hooten NN, Fitzpatrick M, Wood WH et al (2013) Agerelated changes in microRNA levels in serum. Aging 5, 725-740 https://doi.org/10.18632/aging.100603
- Humpel C (2011) Cerebrospinal fluid and blood biomarkers in Alzheimer's disease. World J Psychiatry 1, 8-18 https://doi.org/10.5498/wjp.v1.i1.8
- O'Bryant SE, Mielke MM, Rissman RA et al (2016) Blood-based biomarkers in Alzheimer disease: current state of the science and a novel collaborative paradigm for advancing from discovery to clinic. Alzheimers Dement 13, 45-58 https://doi.org/10.1016/j.jalz.2016.09.014
- Nagaraj S, Laskowska-Kaszub K, Debski KJ et al (2017) Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer's disease patients from non-demented subjects. Oncotarget 8, 16122-16143 https://doi.org/10.18632/oncotarget.15109
- Lau P, Bossers K, Janky Rs et al (2013) Alteration of the microRNA network during the progression of Alzheimer's disease. EMBO Mol Med 5, 1613-1634 https://doi.org/10.1002/emmm.201201974
- Zhang Q, Liu W and Lu G (2017) miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease. J Biosci 42, 397-404 https://doi.org/10.1007/s12038-017-9698-1
- Herskovits AZ and Guarente L (2014) SIRT1 in neurodevelopment and brain senescence. Neuron 5, 471-483 https://doi.org/10.1016/0896-6273(90)90086-u