Journal of Veterinary Science

The Korean Society of Veterinary Science (대한수의학회)
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Chronic cold stress-induced myocardial injury: effects on oxidative stress, inflammation and pyroptosis

  • Hongming Lv (College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University) ;
  • Yvxi He (College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University) ;
  • Jingjing Wu (College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University) ;
  • Li Zhen (College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University) ;
  • Yvwei Zheng (College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University)
  • Received : 2022.07.09
  • Accepted : 2022.09.21
  • Published : 2023.01.31
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Abstract

Background: Hypothermia is a crucial environmental factor that elevates the risk of cardiovascular disease, but the underlying effect is unclear. Objectives: This study examined the role of cold stress (CS) in cardiac injury and its underlying mechanisms. Methods: In this study, a chronic CS-induced myocardial injury model was used; mice were subjected to chronic CS (4℃) for three hours per day for three weeks. Results: CS could result in myocardial injury by inducing the levels of heat shock proteins 70 (HSP70), enhancing the generation of creatine phosphokinase-isoenzyme (CKMB) and malondialdehyde (MDA), increasing the contents of tumor necrosis factor-α (TNF-α), high mobility group box 1 (HMGB1) interleukin1b (IL-1β), IL-18, IL-6, and triggering the depletion of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Multiple signaling pathways were activated by cold exposure, including pyroptosis-associated NOD-like receptor 3 (NLRP3)-regulated caspase-1-dependent/Gasdermin D (GSDMD), inflammation-related toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)-mediated nuclear factor kappa B (NF-κB), and mitogen-activated protein kinase (MAPK), as well as oxidative stressinvolved thioredoxin-1/thioredoxin-interacting protein (Txnip) signaling pathways, which play a pivotal role in myocardial injury resulting from hypothermia. Conclusions: These findings provide new insights into the increased risk of cardiovascular disease at extremely low temperatures.

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References

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