Journal of Applied Biological Chemistry

  • Volume 66
  • /
  • Pages.359-368
  • /
  • 2023
  • /
  • 1976-0442(pISSN)
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  • 2234-7941(eISSN)
The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Effectiveness of Krill Oil in Regulating Skin Moisture

  • Yoon-Seok Chun (AriBnC Co., Ltd.) ;
  • Jongkyu Kim (AriBnC Co., Ltd.) ;
  • Ji-Hoon Lim (Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Namju Lee (AriBnC Co., Ltd.) ;
  • Sae-kwang Ku (Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University)
  • Received : 2023.08.16
  • Accepted : 2023.08.24
  • Published : 2023.12.31
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Abstract

This study aims to explore the impact of Krill Oil (KO, SuperbaTM Boost) on skin moisturization regulation. The research involved five groups: an intact control, a reference group (L-AA 100 mg/kg), and KO groups (400, 200, and 100 mg/kg), each comprising ten mice. Oral administration was conducted for 8 weeks (56 days), during which changes in body weight, hyaluronan, collagen type 1 (COL1), transforming growth factor-β1 (TGF-β1), ceramide, and water contents were analyzed in dorsal back skin tissue. Real-time PCR was employed to assess gene expression related to hyaluronic acid synthesis (HAS1, HAS2, HAS3), COL1 synthesis (COL1A1 and COL1A2), and TGF-β1. Results demonstrated that KO administration significantly increased hyaluronan content, hyaluronic acid synthesis (HAS1, HAS2, HAS3), COL1 content, COL1 synthesis (COL1A1 and COL1A2), TGF-β1 content, TGF-β1 mRNA expression, ceramide content, and water content in a concentration-dependent manner compared to the intact control. Importantly, no discernible disparities were noted between the KO and L-AA groups, even though they received equivalent oral dosages. This study accentuates the potential utility of exogenous KO in the regulation of skin moisture, thus positioning it as a promising avenue for the development of nutricosmetics. Future research endeavors should delve into the role of KO in safeguarding against both intrinsic and extrinsic aging-related skin manifestations, as well as its potential to ameliorate skin wrinkles, in conjunction with its moisturizing attributes.

Keywords

Acknowledgement

We express our heartfelt gratitude for the administrative and technical assistance provided by the College of Korean Medicine at Daegu Haany University and the College of Veterinary Medicine at Kyungpook National University.

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