한국발생생물학회지:발생과생식 (Development and Reproduction)

  • 제27권4호
  • /
  • Pages.221-226
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  • 2023
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  • 2465-9525(pISSN)
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  • 2465-9541(eISSN)
한국발생생물학회 (The Korean Society of Developmental Biology)
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Lin28 is Required for Single Niche Development in the Drosophila Male Gonad

  • Perinthottathil Sreejith (Department of Biomedical Genetics, University of Rochester Medical Center) ;
  • Changsoo Kim (School of Biological Sciences and Technology, Chonnam National University)
  • 투고 : 2023.08.17
  • 심사 : 2023.11.23
  • 발행 : 2023.12.31
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초록

A stem cell niche provides an environment that governs stem cell maintenance and division. Thus, the development of a proper niche is of prime importance to stem cell behaviors. Mechanisms of niche development are beginning to be revealed in the Drosophila male gonad. Niche cells are initially dispersed throughout the gonad, then assemble at its apical tip through the anterior migration of posteriorly located niche cells. The molecular mechanisms of this migration and assembly are still poorly understood. Here we show evidence suggesting that Lin28, an RNA-binding protein and regulator of let7 genesis, might be an intrinsic factor for the anterior migration of niche cells. We found that a dispersed, ectopic niche, a phenotype observed with anterior migration defects, occurs in lin28 mutant gonads. This phenotype is rescued by expression of lin28 in the niche cells. These findings suggest that Lin28 might be required for the anterior migration of niche cells.

키워드

과제정보

This work was supported by grant from the National Research Foundation of Korea (NRF-2021R1A2C1010334). We thank the Bloomington Drosophila Stock Center (BDSC) for flies. We are grateful to S. Dinardo for sharing esg-GAL4.

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