대한본초학회지 (The Korea Journal of Herbology)

  • 제38권2호
  • /
  • Pages.27-34
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  • 2023
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
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송진 유래 abietic acid가 전립선 비대증 모델 rat에 미치는 영향

Inhibitory effects of abietic acid in testosterone-induced benign prostatic hyperplastic rats

  • 김소영 (대구한의대학교 본초약리학교실) ;
  • 김유진 (대구한의대학교 본초약리학교실) ;
  • 김용웅 (대구한의대학교 제약공학과) ;
  • 김미려 (대구한의대학교 본초약리학교실)
  • So-Young, Kim (Department of Herbal Pharmacology, Daegu Hanny University) ;
  • Yoo-Jin, Kim (Department of Herbal Pharmacology, Daegu Hanny University) ;
  • Yong-ung, Kim (Department of Pharmaceutical Engineering, Daegu Haany University) ;
  • Mi Ryeo, Kim (Department of Herbal Pharmacology, Daegu Hanny University)
  • 투고 : 2023.02.15
  • 심사 : 2023.03.25
  • 발행 : 2023.03.30
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초록

Objectives : Currently, the benign prostatic hyperplasia (BPH) is one of the most common urogenital disorder in old men. We were performed to determine the effects of abietic acid (AC), component of pine resin, in benign prostatic hyperplastic Sprague-Dawley rat (SD rat) induced by testosterone injection (IP). Methods : We monitored body weights in SD rat at start and end date of experiment. After end of experiment, the prostate weights were measured in SD rats. Glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels was performed in serum. And we determined the 5-alpha reductase Ⅱ activity, testosterone levels, and dihydrotestosterone levels in prostate tissue and serum using ELISA kit. Results : As results, the prostate wights were increased in BPH group compared to normal group and were decreased in fina, AC30, and AC 50 groups, respectively. Serum GOT levels were decreased in AC50 group compared to BPH group. And Serum GPT levels of AC30 and AC50 groups were lower than BPH group. In addition, the 5-alpha reductase Ⅱ activity, testosterone levels, and dihydrotestosterone levels were decreased the fina, AC10, AC30, and AC 50 groups contrast to the BPH group. Furthermore, 5-alpha reductase Ⅱ activity, testosterone levels, and dihydrotestosterone levels were decreased dose dependent in AC groups compared to BPH group. Conclusion : These results suggest that AC could be used as a potential material for the treatment of BPH by decreasing the androgen levels in benign prostatic hyperplasia model rats.

키워드

과제정보

This work was carried out with the support of National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2021R1A2C201471711), Republic of Korea.

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