The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Study on the Anti-stress Effect of Chenwangbosim-Dan Extract∘Fermented Rice Extract (GABA ː gamma-aminobutyric acid 30%) Complex : A double-blind, randomized, placebo-controlled study

천왕보심단(天王補心丹)∘쌀발효추출물(GABAːgamma-aminobutyric acid 30%) 복합물의 항(抗)스트레스에 대한 유효성 연구ː무작위 배정 및 이중맹검

  • Choyoung, Hong (LG H&H Co., Ltd.) ;
  • Seo, Sang Gwon (LG H&H Co., Ltd.) ;
  • Seunggon, Na (LG H&H Co., Ltd.) ;
  • Hosong, Cho (LG H&H Co., Ltd.) ;
  • Mi-Kyung, Lee (LG H&H Co., Ltd.) ;
  • Mu Hyun, Jin (LG H&H Co., Ltd.) ;
  • Seok-Seon, Roh (Department of Korean Medicine, College of Korean Medicine, Daejeon University) ;
  • Youngsung, Ju (Department of Korean Medicine, College of Korean Medicine, Woosuk University)
  • 홍초영 (LG생활건강 기술연구원) ;
  • 서상권 (LG생활건강 기술연구원) ;
  • 나승곤 (LG생활건강 기술연구원) ;
  • 조호성 (LG생활건강 기술연구원) ;
  • 이미경 (LG생활건강 기술연구원) ;
  • 진무현 (LG생활건강 기술연구원) ;
  • 노석선 (대전대학교 한의과대학 한의학과) ;
  • 주영승 (우석대학교 한의과대학 한의학과)
  • Received : 2022.12.21
  • Accepted : 2023.03.25
  • Published : 2023.03.30
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Abstract

Objectives : From this study, we sight to identify Anti-stress effect of Chenwangbosim-Dan (Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA : gamma-aminobutyric acid 30%) Complex Methods : In order to measure the degree of functional evaluation of tension relief due to stress, it was evaluated whether the psychological indicators VAS(Visual Analog Scale) and POMS(Profile Of Mood State) were improved. Which is generally used for stress measurement and has a high frequency of clinical use. All clinical trial subjects were required to take the drug once a day at 9 ± 30 min in the morning for 2 weeks. Results : After intake, the group that Chenwangbosim-Dan(Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA : gamma-aminobutyric acid 30%) Complex had a statistically significant improvement effect compared to before intake due to an improved 30.81% of the VAS scores. The POMS-T score improved 54.13%, the POMS-V score improved 117.5% and the POMS-F score improved 59%, which had a statistically significant effect compared to Placebo group (p<0.001). There is a significant difference between two group, so even considering the placebo effect, the anti stress effect was confirmed in the Chenwangbosim-Dan (Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA : gamma-aminobutyric acid 30%) Complex intake group. Conclusions : The above results showed that the Chenwangbosim-Dan(Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA : gamma-aminobutyric acid 30%) Complex had an anti-stress effect. Therefore, it is expected to be developed as a safe and comfortable mental care health functional food that can reduce the risk of drug abuse.

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