DOI QR코드

DOI QR Code

Effects of Taraxacum mongolicum Extract on Blood Glucose Levels and Lipid Profiles in Streptozotocin-Induced Diabetic Rats

  • Hye Kyoung, Han (Dept. of Food and Nutrition, KyungBuk College) ;
  • Eun Young, Choi (Dept. of Food and Nutrition, Bucheon University)
  • 투고 : 2023.01.13
  • 심사 : 2023.02.08
  • 발행 : 2023.02.28

초록

This study was designed to evaluate antihyperglycemic and antihyperlipidemic effects of ethanol extracts of Taraxacum mongolicum(T.m.) on streptozotocin (STZ)-induced diabetic rats. Sprague-Dawley rats were randomly assigned to five groups: normal (NC), STZ-control (DC), and three experimental groups. Diabetes was induced in Sprague-Dawley rats with a single intravenous injection [45 mg/kg body weight (b.w.)] of STZ. An ethanol extract of T.m. was orally given to diabetic rats for 14 days. Three experimental groups were additionally treated with T.m. extract at doses of 1 g/kg b.w./day for T.m.-1, 2 g/kg b.w./day for T.m.-2, and 3 g/kg b.w./day for T.m.-3. Oral administration of T.m.-2 significantly increased their body weights. T.m.-1 and T.m.-2 significantly decreased aspartate aminotransferase (AST) levels than DC. T.m.-1 and T.m.-2 group significantly decreased blood glucose levels. Total cholesterol, triglycerides, and free fatty acids were significantly decreased whereas high-density lipoprotein cholesterol was significantly increased in groups treated with T.m. extract than those in the DC group. These results support the fact that administration of T.m. extract can reduce hyperglycemia and hyperlipidemia risk in diabetic rats.

키워드

참고문헌

  1. Ajebli M, Eddouks M. 2019. Flavonoid-enriched extract from desert plant Warionia saharae improves glucose and cholesterol levels in diabetic rats. Cardiovasc Hematol Agents Med Chem 17:28-39 https://doi.org/10.2174/1871525717666190121143934
  2. Arora SK, Verma PR, Itankar PR, Prasad SK, Nakhate KT. 2021. Evaluation of pancreatic regeneration activity of Tephrosia purpurea leaves in rats with streptozotocin-induced diabetes. J Tradit Complement Med 11:435-445 https://doi.org/10.1016/j.jtcme.2021.03.001
  3. Barbera A, Rodriguez-Gil JE, Guinovart JJ. 1994. Insulin-like actions of tungstate in diabetic rats. Normalization of hepatic glucose metabolism. J Biol Chem 269:20047-20053 https://doi.org/10.1016/S0021-9258(17)32125-7
  4. Bauer JD. 1982. Clinical Laboratory Methods. 9 th ed. p 188-189. Mosby
  5. Betteridge DJ. 2001. Dyslipidaemia and diabetes. Prac Diabetes Int 18:201-207 https://doi.org/10.1002/pdi.231
  6. Clark TA, Heyliger CE, Edel AL, Goel DP, Pierce GN. 2004. Codelivery of a tea extract prevents morbidity and mortality associated with oral vanadate therapy in streptozotocininduced diabetic rats. Metabolism 53:1145-1151 https://doi.org/10.1016/j.metabol.2004.03.017
  7. Dai S, McNeill JH. 1994. One-year treatment of non-diabetic and streptozotocin-diabetic rats with vanadyl sulphate did not alter blood pressure or haematological indices. Pharmacol Toxicol 74:110-115 https://doi.org/10.1111/j.1600-0773.1994.tb01084.x
  8. Durrington PN, Stephens WP. 1980. The effects of treatment with insulin on serum high-density-lipoprotein cholesterol in rats with streptozotocin-induced diabetes. Clin Sci 59:71-74 https://doi.org/10.1042/cs0590071
  9. El-Naggar ME, Al-Joufi F, Anwar M, Attia MF, El-Bana MA. 2019. Curcumin-loaded PLA-PEG copolymer nanoparticles for treatment of liver inflammation in streptozotocin-induced diabetic rats. Colloids Surf B Biointerfaces 177:389-398 https://doi.org/10.1016/j.colsurfb.2019.02.024
  10. Finley PR, Schifman RB, Williams RJ, Lichti DA. 1978. Cholesterol in high-density lipoprotein: Use of Mg2+/dextran Mg2+/dextran sulfate in its enzymic measurement. Clin Chem 24:931-933 https://doi.org/10.1093/clinchem/24.6.931
  11. Giegel JL, Ham AB, Clema W. 1975. Manual and semiautomated procedures for measurement of triglycerides in serum. Clin Chem 21:1575-1581 https://doi.org/10.1093/clinchem/21.11.1575
  12. Han HK, Choi EY. 2020. Effects of Atractylodes lancea on plasma glucose and lipid profile in streptozotocin induced diabetic rats. Korean J Food Nutr 33:544-550 https://doi.org/10.9799/KSFAN.2020.33.5.544
  13. Han HK, Yoon SJ, Kim GH. 2009. Effects of Compositae plants on plasma glucose and lipid level in streptozotocin induced diabetic rats. J Korean Soc Food Sci Nutr 38:674-682 https://doi.org/10.3746/JKFN.2009.38.6.674
  14. He K, Wang J, Shi H, Yu Q, Zhang X, Guo M, Sun H, Lin X, Wu Y, Wang L, Wang Y, Xian X, Liu G. 2019. An interspecies study of lipid profiles and atherosclerosis in familial hypercholesterolemia animal models with low-density lipoprotein receptor deficiency. Am J Transl Res 11:3116-3127
  15. Heather LC, Clarke K. 2011. Metabolism, hypoxia and the diabetic heart. J Mol Cell Cardiol 50:598-605  https://doi.org/10.1016/j.yjmcc.2011.01.007
  16. Kang TH, Choi SZ, Lee TH, Son MW, Kim SY. 2008. Characteristics of antidiabetic effect of Dioscorea rhizoma (1) - Hypoglycemic effect. Korean J Food Nutr 21:425-429
  17. Karigidi KO, Akintimehin ES, Omoboyowa DA, Adetuyi FO, Olaiya CO. 2020. Effect of Curculigo pilosa supplemented diet on blood sugar, lipid metabolism, hepatic oxidative stress and carbohydrate metabolism enzymes in streptozotocin-induced diabetic rats. J Diabetes Metab Disord 19:1173-1184 https://doi.org/10.1007/s40200-020-00618-w
  18. Khalid M, Petroianu G, Adem A. 2022. Advanced glycation end products and diabetes mellitus: Mechanisms and perspectives. Biomolecules 12:542
  19. Kim SH, Kang JS, Lee SJ, Chung YJ. 2008a. Antidiabetic effect of Korean red ginseng by puffing process in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 37: 701-707 https://doi.org/10.3746/JKFN.2008.37.6.701
  20. Kim SH, Ryu DS, Lee MY, Kim KH, Kim YH, Lee DS. 2008b. Anti-diabetic activity of polysaccharide from Salicornia herbacea. Korean J Microbiol Biotechnol 36:43-48
  21. Kim Y, Nho SJ, Woo G, Kim H, Park S, Kim Y, Park O, Oh K. 2021. Trends in the prevalence and management of major metabolic risk factors for chronic disease over 20 years: Findings from the 1998-2018 Korea National Health and Nutrition Examination Survey. Epidemiol Health 43:e2021028
  22. Koh JB, Choi MA, Kim JY, Rho MH, Kim DJ. 1999. Effects of tea fungus/kombucha beverage on serum protein levels and enzyme activity in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 28:1137-1143
  23. Lee NY. 2013. Antioxidant effect and tyrosinase inhibition activity of seaweeds ethanol extracts. J Korean Soc Food Nutr 42:1893-1898 https://doi.org/10.3746/jkfn.2013.42.12.1893
  24. Lee SS, Kim JW. 1999. Pharmacological studies on the water extract of fractions of Lycium chinese Mill. Duksung Bull Pharm Sci 2:29-41
  25. Ma Y, Chen M, Guo Y, Liu J, Chen W, Guan M, Wang Y, Zhao X, Wang X, Li H, Meng L, Wen Y, Wang Y. 2019. Prevention and treatment of infectious diseases by traditional Chinese medicine: A commentary. APMIS 127:372-384 https://doi.org/10.1111/apm.12928
  26. Nikkila EA, Kekki M. 1973. Plasma triglyceride transport kinetics in diabetes mellitus. Metabolism 22:1-22 https://doi.org/10.1016/0026-0495(73)90024-3
  27. Reeves PG. 1997. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr 127:838S-841S https://doi.org/10.1093/jn/127.5.838S
  28. Reeves PG. 1997. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr 127:838S-841S https://doi.org/10.1093/jn/127.5.838S
  29. Reitman S, Frankel S. 1957. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28:56-63 https://doi.org/10.1093/ajcp/28.1.56
  30. Rho MH, Choi MA, Koh JB. 1998. Effects of serum raw soy flour (yellow and black) on serum protein concentrations and enzyme activity in streptozotocin-diabetic rats. J Korean Soc Food Sci Nutr 27:724-730
  31. Richmond W. 1973. Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem 19:1350-1356 https://doi.org/10.1093/clinchem/19.12.1350
  32. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R. 2019. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9 th edition. Diabetes Res Clin Pract 157:107843
  33. Salau VF, Erukainure OL, Ijomone OM, Islam MS. 2022. Caffeic acid regulates glucose homeostasis and inhibits purinergic and cholinergic activities while abating oxidative stress and dyslipidaemia in fructose-streptozotocin-induced diabetic rats. J Pharm Pharmacol 74:973-984 https://doi.org/10.1093/jpp/rgac021
  34. Shi S, Zhao Y, Zhou H, Zhang Y, Jiang X, Huang K. 2008. Identification of antioxidants from Taraxacum mongolicum by high-performance liquid chromatography-diode array detection-radical-scavenging detection-electrospray ionization mass spectrometry and nuclear magnetic resonance experi- ments. J Chromatogr A 1209:145-152 https://doi.org/10.1016/j.chroma.2008.09.004
  35. Siegel RD, Cupples A, Schaefer EJ, Wilson PWF. 1996. Lipoproteins, apolipoproteins, and low-density lipoprotein size among diabetics in the Framingham offspring study. Metabolism 45:1267-1272 https://doi.org/10.1016/S0026-0495(96)90246-2
  36. Sun K, Ding M, Fu C, Li P, Li T, Fang L, Xu J, Zhao Y. 2023. Effects of dietary wild bitter melon (Momordica charantiavar. abbreviate Ser.) extract on glucose and lipid metabolism in HFD/STZ-induced type 2 diabetic rats. J Ethnopharmacol 306:116154
  37. Taniguchi H, Kobayashi-Hattori K, Tenmyo C, Kamei T, Uda Y, Sugita-Konishi Y, Oishi Y, Takita T. 2006. Effect of Japanese radish (Raphanus sativus) sprout (Kaiware-daikon) on carbohydrate and lipid metabolisms in normal and streptozotocin-induced diabetic rats. Phytother Res 20:274-278 https://doi.org/10.1002/ptr.1851
  38. Tella T, Masola B, Mukaratirwa S. 2019. The effect of Psidium guajava aqueous leaf extract on liver glycogen enzymes, hormone sensitive lipase and serum lipid profile in diabetic rats. Biomed Pharmacother 109:2441-2446 https://doi.org/10.1016/j.biopha.2018.11.137
  39. Zeng X, Zhang P, He W, Qin C, Chen S, Tao L, Wang Y, Tan Y, Gao D, Wang B, Chen Z, Chen W, Jiang YY, Chen YZ. 2018. NPASS: Natural product activity and species source database for natural product research, discovery and tool development. Nucleic Acids Res 46:D1217-D1222 https://doi.org/10.1093/nar/gkx1026
  40. Zhang Y, Hu YF, Li W, Xu GY, Wang KR, Li L, Luo H, Zou L, Wu JS. 2022. Updates and advances on pharmacological properties of Taraxacum mongolicum Hand.-Mazz and its potential applications. Food Chem 373:131380