Journal of Ginseng Research

  • 제47권1호
  • /
  • Pages.9-22
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  • 2023
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
권호 표지
DOI QR코드

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Ginseng polysaccharides: Potential antitumor agents

  • Ruizhi, Tao (Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine) ;
  • Keqin, Lu (Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine) ;
  • Gangfan, Zong (Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine) ;
  • Yawen, Xia (Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine) ;
  • Hongkuan, Han (Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine) ;
  • Yang, Zhao (Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine) ;
  • Zhonghong, Wei (Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine) ;
  • Yin, Lu (Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine)
  • 투고 : 2022.03.03
  • 심사 : 2022.07.11
  • 발행 : 2023.01.02
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초록

As a famous herbal medicine in China and Asia, ginseng (Panax ginseng C. A. Meyer) is also known as the "King of All Herbs" and has long been used in medicine and healthcare. In addition to the obvious biological activities of ginsenosides, ginseng polysaccharides (GPs) exhibit excellent antitumor, antioxidant stress, and immunomodulatory effects. In particular, GPs can exert an antitumor effect and is a potential immunomodulator. However, due to the complexity and diversity in the structures and components of GPs, their specific physicochemical properties, and underlying mechanisms remain unclear. In this article, we have summarized the factors influencing the antitumor activity of GPs and their mechanism of action, including the stimulation of the immune system, regulation of the gut microbiota, and direct action on tumor cells

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과제정보

This work was financially supported by National Natural Science Foundation of China (82004124, 81961128020, and 81973734), China Postdoctoral Science Foundation (2020M671551), Natural Science Foundation of Jiangsu Province (BK20200154), Jiangsu Province Traditional Chinese Medicine Leading Talents Program (SLJ0229), The Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine (2020YLXK20), Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX22-2013 and KYCX22-2039).

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