Journal of Convergence Korean Medicine (대한융합한의학회지)

Academy of Convergence Korean Medicine (대한융합한의학회)
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Ameliorative effects of Glechoma hederacea var. longituba extract on oxazolone-induced atopic dermatitis-like skin lesions

긴병꽃풀 추출물의 oxazolone-유도 아토피 피부염 개선 효과

  • Dae Yong Kim (College of Korean Medicine, Woosuk University)
  • 김대용 (우석대학교 한의과대학)
  • Published : 2023.12.31
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Abstract

Objectives: This study aimed to investigate the anti-atopic properties of Glechoma hederacea var. longituba extracts (GHE) in murine atopic dermatitis model. Methods: BALB/c mouse ear stimulated with oxazolone (OX) for 4 weeks, then 1% GHE was topically applied every two days for 3 weeks to mouse. Ear thickness was measured by a digital thickness gauge. The ears tissues were collected and subjected to hematoxylin-eosin (H&E) and toluidine blue (TB) staining. Results: Treatment with GHE successfully alleviated the symptoms of atopic dermatitis, such as erythema, horny substance, and swelling. The infiltration of lymphocytes and mast cells were significantly reduced following GHE treatment. Conclusion: Taken together, our results showed that GHE possessed the potential to be a novel immunomodulatory drug against atopic dermatitis.

Keywords

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