대한의생명과학회지 (Biomedical Science Letters)

  • 제29권4호
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  • Pages.242-248
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  • 2023
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
권호 표지
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The Inhibitory Effects of Glycyrrhiza uralensis on human Platelet Aggregation and Thrombus Formation

  • Seung Na Ko (Department of Biomedical Laboratory Science, Far East University) ;
  • Ji Won Son (Department of Biomedical Laboratory Science, Far East University) ;
  • Gyu Ri Kim (Department of Biomedical Laboratory Science, Far East University) ;
  • Min Seon Kim (Department of Biomedical Laboratory Science, Far East University) ;
  • Yea Jin Lee (Department of Biomedical Laboratory Science, Far East University) ;
  • Seung Ju Kim (Department of Biomedical Laboratory Science, Far East University) ;
  • Ji Hyeon Shin (Department of Biomedical Laboratory Science, Far East University) ;
  • Da In Jo (Department of Biomedical Laboratory Science, Far East University) ;
  • Woo Young Bok (Department of Biomedical Laboratory Science, Far East University) ;
  • Hye Gyo Oh (Department of Biomedical Laboratory Science, Far East University) ;
  • Hyuk-Woo Kwon (Department of Biomedical Laboratory Science, Far East University)
  • 투고 : 2023.11.01
  • 심사 : 2023.12.07
  • 발행 : 2023.12.31
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초록

Platelets are activated at the sites of vascular injury by a number of molecules, including adenosine diphosphate, collagen and thrombin. The full platelet aggregation is absolutely essential for the normal hemostasis. Glycyrrhiza glabra is a well-known medicinal herb that grows in various parts of the world and is known to have various effects such as antioxidant, anti-inflammatory, anti-atherogenic, anti-osteoporotic and skin-whitening. However, the platelet inhibitory effect of Glycyrrhiza glabra extract (GGE) has not been identified. In this study, we investigated if GGE inhibited platelet aggregation. We observed that GGE inhibited collagen-induced platelet aggregation, Ca2+ mobilization, and thromboxane A2 generation. In addition, GGE suppressed phosphorylation of phosphatidylinositol-3 kinase (PI3K), Akt and elevated phosphorylation of inositol 1,4,5-trisphosphate receptor (IP3R), vasodilator stimulated phosphoprotein (VASP). Taken together, GGE showed strong antiplatelet effects and may be used to block platelet-mediated cardiovascular diseases.

키워드

과제정보

This work was supported by a 2022 Far East University Research Grant (FEU2022S04).

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