Journal of Korean Foot and Ankle Society (대한족부족관절학회지)

Korean Foot & Ankle Society (대한족부족관절학회)
권호 표지
DOI QR코드

DOI QR Code

Understanding Atelocollagen Injections for Patients with Foot and Ankle Diseases

족부족관절 질환 환자를 위한 아텔로콜라겐 주사의 이해

  • Hee-Chul Gwak (Busan Healthyfriend Orthopedic Surgery Clinic) ;
  • Jun-Min Yoon (Department of Orthopedic Surgery, Busan Paik Hospital, College of Medicine, Inje University) ;
  • Dae-Yoo Kim (Department of Orthopedic Surgery, Busan Paik Hospital, College of Medicine, Inje University)
  • 곽희철 (부산건우정형외과의원) ;
  • 윤준민 (인제대학교 의과대학 부산백병원 정형외과학교실) ;
  • 김대유 (인제대학교 의과대학 부산백병원 정형외과학교실)
  • Received : 2023.10.24
  • Accepted : 2023.10.28
  • Published : 2023.12.15
Download PDF
⟨ Previous Next ⟩

Abstract

Collagen is the most common structural protein in the connective tissues of vertebrates, playing a crucial role in maintaining the tissue structure and wound healing. Atelocollagen retains the original properties of collagen but does not induce inflammatory cytokines. Atelocollagen is extracted from various animals and humans, with bovine-derived collagen being the most commonly used. The safety and efficacy of atelocollagen have been demonstrated through multiple studies, but further research will be needed in the field of orthopedics regarding its range of use and effects. Foot and ankle diseases have attracted little research attention, highlighting the need for further studies.

Keywords

References

  1. Gallo N, Natali ML, Sannino A, Salvatore L. An overview of the use of equine collagen as emerging material for biomedical applications. J Funct Biomater. 2020;11:79. doi: 10.3390/jfb11040079.
  2. Von Der Mark K. Structure, biosynthesis and gene regulation of collagens in cartilage and bone. In: Seibel MJ, Robins SP, Bilezikian JP, editors. Dynamics of bone and cartilage metabolism. 2nd ed. Burlington: Elsevier; 2006. p.3-40.
  3. Gelse K, Poschl E, Aigner T. Collagens--structure, function, and biosynthesis. Adv Drug Deliv Rev. 2003;55:1531-46. doi: 10.1016/j.addr.2003.08.002.
  4. Salvatore L, Gallo N, Natali ML, Terzi A, Sannino A, Madaghiele M. Mimicking the hierarchical organization of natural collagen: toward the development of ideal scaffolding material for tissue regeneration. Front Bioeng Biotechnol. 2021;9:644595. doi: 10.3389/fbioe.2021.644595.
  5. Amirrah IN, Lokanathan Y, Zulkiflee I, Wee MFMR, Motta A, Fauzi MB. A comprehensive review on collagen type I development of biomaterials for tissue engineering: from biosynthesis to bioscaffold. Biomedicines. 2022;10:2307. doi: 10.3390/biomedicines10092307.
  6. Lynn AK, Yannas IV, Bonfield W. Antigenicity and immunogenicity of collagen. J Biomed Mater Res B Appl Biomater. 2004;71:343-54. doi: 10.1002/jbm.b.30096.
  7. Suh DS, Yoo JC, Woo SH, Kwak AS. Intra-articular atelocollagen injection for the treatment of articular cartilage defects in rabbit model. Tissue Eng Regen Med. 2021;18:663-70. doi: 10.1007/s13770-021-00337-0.
  8. Liang R, Woo SL, Takakura Y, Moon DK, Jia F, Abramowitch SD. Long-term effects of porcine small intestine submucosa on the healing of medial collateral ligament: a functional tissue engineering study. J Orthop Res. 2006;24:811-9. doi: 10.1002/jor.20080.
  9. Woo SL, Takakura Y, Liang R, Jia F, Moon DK. Treatment with bioscaffold enhances the the fibril morphology and the collagen composition of healing medial collateral ligament in rabbits. Tissue Eng. 2006;12:159-66. doi: 10.1089/ten.2006.12.159.
  10. Jin SH, Kim WJ, Park HS, Kim CH, Chung RK, Baik HJ, et al. The effect of atelocollagen on the treatment of chronic anterior talofibular ligament tear: a case report. Int J Pain. 2019;10:10-6.
  11. Jang YH, Kim DS. Atelocollagen injections improve outcomes in the nonsurgical treatment of grade III medial collateral ligament injuries. Clin Orthop Surg. 2023;15:e62.
  12. Kim M, Choi YS, You MW, Kim JS, Young KW. Sonoelastography in the evaluation of plantar fasciitis treatment: 3-month follow-up after collagen injection. Ultrasound Q. 2016;32:327-32. doi: 10.1097/RUQ.0000000000000233.
  13. Corrado B, Bonini I, Tarantino D, Sirico F.Ultrasound-guided collagen injections for treatment of plantar fasciopathy in runners: a pilot study and case series. J Hum Sport Exerc. 2020;15(3proc):S793-805. doi: 10.14198/jhse.2020.15.Proc3.30.
  14. Kim DK, Ahn J, Kim SA, Go EJ, Lee DH, Park SC, et al. Improved healing of rabbit patellar tendon defects after an atelocollagen injection. Am J Sports Med. 2021;49:2924-32. doi: 10.1177/03635465211030508.
  15. Kim JH, Kim DJ, Lee HJ, Kim BK, Kim YS. Atelocollagen injection improves tendon integrity in partial-thickness rotator cuff tears: a prospective comparative study. Orthop J Sports Med. 2020;8:2325967120904012. doi: 10.1177/2325967120904012.
  16. Chae SH, Won JY, Yoo JC. Clinical outcome of ultrasound-guided atelocollagen injection for patients with partial rotator cuff tear in an outpatient clinic: a preliminary study. Clin Shoulder Elb. 2020;23:80-5. doi: 10.5397/cise.2020.00066.
  17. Jeong JY, Khil EK, Kim TS, Kim YW. Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healing. Clin Shoulder Elb. 2021;24:147-55. doi: 10.5397/cise.2021.00234.
  18. Lee YK, Young KW, Kim JS, Lee HS, Cho WJ, Kim HN. Arthroscopic microfracture with atelocollagen augmentation for osteochondral lesion of the talus: a multicenter randomized controlled trial. BMC Musculoskelet Disord. 2020;21:716. doi: 10.1186/s12891-020-03730-3.
  19. Tan MWP, Tay KS, Yeo EMN. Atelocollagen-induced chondrogenesis versus microfracture alone for osteochondral lesions of the talus: surgical technique and a 1-year clinical outcome study. Foot Ankle Spec. Published online July 11, 2022; doi: 10.1177/19386400221107003.
  20. De Luca P, Colombini A, Carimati G, Beggio M, de Girolamo L, Volpi P. Intra-articular injection of hydrolyzed collagen to treat symptoms of knee osteoarthritis. A functional in vitro investigation and a pilot retrospective clinical study. J Clin Med. 2019;8:975. doi: 10.3390/jcm8070975.
  21. Lee HS, Oh KJ, Moon YW, In Y, Lee HJ, Kwon SY. Intra-articular injection of type I atelocollagen to alleviate knee pain: a double-blind, randomized controlled trial. Cartilage. 2021;13(1_suppl):342S-50S. doi: 10.1177/1947603519865304.
  22. Volpi P, Zini R, Erschbaumer F, Beggio M, Busilacchi A, Carimati G. Effectiveness of a novel hydrolyzed collagen formulation in treating patients with symptomatic knee osteoarthritis: a multicentric retrospective clinical study. Int Orthop. 2021;45:375-80. doi: 10.1007/s00264-020-04616-8.
  23. Gadomski BC, Labus KM, Puttlitz CM, McGilvray KC, Regan DP, Nelson B, et al. Evaluation of lumbar spinal fusion utilizing recombinant human Platelet Derived Growth Factor-B chain homodimer (rhPDGF-BB) combined with a bovine collagen/β-tricalcium phosphate (β-TCP) matrix in an ovine model. JOR Spine. 2021;4:e1166. doi: 10.1002/jsp2.1166.
  24. Pavelka K, Jarosova H, Milani L, Prochazka Z, Kostiuk P, Kotlarova L, et al. Efficacy and tolerability of injectable collagen-containing products in comparison to trimecaine in patients with acute lumbar spine pain (Study FUTURE-MD-Back Pain). Physiol Res. 2019;68(Suppl 1):S65-74. doi: 10.33549/physiolres.934326.
  25. Silvipriya K, Krishna Kumar K, Bhat A, Dinesh Kumar B, John A, lakshmanan P. Collagen: animal sources and biomedical application. J App Pharm Sci. 2015;5:123-7. doi: 10.7324/JAPS.2015.50322.
  26. Rich A, Crick FH. The molecular structure of collagen. J Mol Biol. 1961;3:483-506. doi: 10.1016/s0022-2836(61)80016-8.
  27. Bou-Gharios G, Abraham D, de Crombrugghe B.Type I collagen structure, synthesis, and regulation. In: Bilezikian JP, Martin TJ, Clemens TL, Rosen CJ, editors. Principles of bone biology. 4th ed. Cambridge: Academic Press; 2020. p.295-337.
  28. Kadler KE, Holmes DF, Trotter JA, Chapman JA. Collagen fibril formation. Biochem J. 1996;316(Pt 1):1-11. doi: 10.1042/bj3160001.
  29. Sorushanova A, Delgado LM, Wu Z, Shologu N, Kshirsagar A, Raghunath R, et al. The collagen suprafamily: from biosynthesis to advanced biomaterial development. Adv Mater. 2019;31:e1801651. doi: 10.1002/adma.201801651.
  30. Shoulders MD, Raines RT. Collagen structure and stability. Annu Rev Biochem. 2009;78:929-58. doi: 10.1146/annurev.biochem.77.032207.120833.
  31. Varani J, Dame MK, Rittie L, Fligiel SE, Kang S, Fisher GJ, et al. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol. 2006;168:1861-8. doi: 10.2353/ajpath.2006.051302.
  32. Kjaer M, Langberg H, Heinemeier K, Bayer ML, Hansen M, Holm L, et al. From mechanical loading to collagen synthesis, structural changes and function in human tendon. Scand J Med Sci Sports. 2009;19:500-10. doi: 10.1111/j.1600-0838.2009.00986.x.
  33. Martinello T, Bronzini I, Volpin A, Vindigni V, Maccatrozzo L, Caporale G, et al. Successful recellularization of human tendon scaffolds using adipose-derived mesenchymal stem cells and collagen gel. J Tissue Eng Regen Med. 2014;8:612-9. doi: 10.1002/term.1557.
  34. Neuber F.Fat transplant. Report on the German Society's negotiations for 300 surgeries. Zentralbl Chir. 1893;22:66. German.
  35. Kontis TC, Rivkin A.The history of injectable facial fillers. Facial Plast Surg. 2009;25:67-72. doi: 10.1055/s-0029-1220645.
  36. Attenello NH, Maas CS.Injectable fillers: review of material and properties. Facial Plast Surg. 2015;31:29-34. doi: 10.1055/s-0035-1544924.
  37. Eppley BL, Dadvand B. Injectable soft-tissue fillers: clinical overview. Plast Reconstr Surg. 2006;118:98e-106e. doi: 10.1097/01.prs.0000232436.91409.30.
  38. Requena L, Requena C, Christensen L, Zimmermann US, Kutzner H, Cerroni L.Adverse reactions to injectable soft tissue fillers. J Am Acad Dermatol. 2011;64:1-34; quiz 35-6. doi: 10.1016/j.jaad.2010.02.064. Erratum in: J Am Acad Dermatol. 2011;64:1178.
  39. Cheng LY, Sun XM, Tang MY, Jin R, Cui WG, Zhang YG. An update review on recent skin fillers. Plast Aesthet Res. 2016;3:92-9. doi: 10.20517/2347-9264.2015.124.
  40. Inaba S, Nagahara S, Makita N, Tarumi Y, Ishimoto T, Matsuo S, et al. Atelocollagen-mediated systemic delivery prevents immunostimulatory adverse effects of siRNA in mammals. Mol Ther. 2012;20:356-66. doi: 10.1038/mt.2011.221.
  41. Magarian EM, Vavken P, Connolly SA, Mastrangelo AN, Murray MM. Safety of intra-articular use of atelocollagen for enhanced tissue repair. Open Orthop J. 2012;6:231-8. doi: 10.2174/1874325001206010231.
  42. Klewin-Steinbock S, Nowak-Terpilowska A, Adamski Z, Grocholewicz K, Wyganowska-Swiatkowska M. Effect of injectable equine collagen type I on metabolic activity and apoptosis of gingival fibroblasts. Adv Dermatol Alergol. 2021;38:440-5. doi: 10.5114/ada.2020.94256.
  43. Buck DW 2nd, Alam M, Kim JY. Injectable fillers for facial rejuvenation: a review. J Plast Reconstr Aesthet Surg. 2009;62:11-8. doi: 10.1016/j.bjps.2008.06.036.
  44. Douglas RS, Donsoff I, Cook T, Shorr N. Collagen fillers in facial aesthetic surgery. Facial Plast Surg. 2004;20:117-23. doi: 10.1055/s-2004-861751.
  45. Jimenez-Cano VM, Cuevas Garcia JC, Fabregat-Hernandez J. [Effectiveness of collagen injection for plantar fasciitis: randomised clinical trial]. Rev Esp Pod. 2022;33:14-20. Spanish. doi: 10.20986/revesppod.2022.1608/2021.
  46. Kim J, Cho H, Young K, Park J, Lee J, Suh D. In vivo animal study and clinical outcomes of autologous atelocollagen-induced chondrogenesis for osteochondral lesion treatment. J Orthop Surg Res. 2015;10:82. doi: 10.1186/s13018-015-0212-x.
  47. Dhinsa BS, Bowman N, Morar Y, Chettiar K, Wiffen L, Armitage A, et al. The use of collagen injections in the treatment of metatarsalgia: a case report. J Foot Ankle Surg. 2010;49:565.e5-7. doi: 10.1053/j.jfas.2010.07.013.