한국해양바이오학회지 (Journal of Marine Bioscience and Biotechnology)

한국해양바이오학회 (The Korean Society for Marine Biotechnology)
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미끈뼈대그물말(Dictyopteris divaricata) 추출물의 항비만 효과

Effect of Dictyopteris divaricata Extracts on Adipogenesis in 3T3-L1 Preadipocytes

  • Chul Hwan Kim (National Marine Biodiversity Institute of Korea) ;
  • Seok-Chun Ko (National Marine Biodiversity Institute of Korea) ;
  • Hyun-Soo Kim (National Marine Biodiversity Institute of Korea) ;
  • Gun-Woo Oh (National Marine Biodiversity Institute of Korea) ;
  • Ji-Yul Kim (National Marine Biodiversity Institute of Korea) ;
  • Kyung Woo Kim (National Marine Biodiversity Institute of Korea) ;
  • Jeong Min Lee (National Marine Biodiversity Institute of Korea) ;
  • Myeong-Seok Lee (National Marine Biodiversity Institute of Korea) ;
  • Yun Gyeong Park (National Marine Biodiversity Institute of Korea) ;
  • Gyeong Lee (National Marine Biodiversity Institute of Korea) ;
  • Jae-Young Je (School of Smart Healthcare, Pukyong National University) ;
  • Jung Hye Won (National Marine Biodiversity Institute of Korea) ;
  • Young Jun Kim (Department of Food Regulatory Science, Korea University) ;
  • Dae-Sung Lee (National Marine Biodiversity Institute of Korea)
  • 투고 : 2023.08.07
  • 심사 : 2023.09.21
  • 발행 : 2023.12.31
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초록

Dictyopteris divaricata, a type of marine brown algae, has been studied for its various biological properties, including anti-inflammatory, antidiabetic, and whitening effects. However, its potential antiobesity effects have not been extensively explored. This study aimed to examine the impact of D. divaricata ethanol extract (DDE) on adipocyte differentiation and adipogenesis using 3T3-L1 preadipocytes. Our results showed that when 3T3-L1 preadipocytes were treated with noncytotoxic concentrations of DDE there was a concentration-dependent decrease in fat accumulation rate and triglycerid production compared with the control. Furthermore, DDE significantly reduced the expression of transcription factors (PPARγ, C/EBPα, and SREBP-1) and fatty acid transport protein (FABP4), which are crucial for 3T3-L1 preadipocyte differentiation. These findings suggest that DDE may exhibit antiobesity effects by suppressing the expression of lipogenic transcription factors and fatty acid transport proteins. Therefore, DDE holds potential as a therapeutic agent for obesity.

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과제정보

본 논문은 해수부의 재원으로 국립해양생물자원관(2023M00500)의 지원을 받아 수행된 연구이며, 이에 감사드립니다.

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