Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
권호 표지
DOI QR코드

DOI QR Code

Oldenlandia diffusa Ameliorates on Atopic Dermatitis in Mice

  • Mi-Ok Yang (Wonkwang Institute of Nature Healthcare Studies) ;
  • Noh-Yil Myung (Department of Korean Medicine and Food Therapy, Wonkwang Digital University)
  • Received : 2023.10.29
  • Accepted : 2023.11.07
  • Published : 2023.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

Oldenlandia diffusa (OD), a member of the Rubiaceae family, has been used for treating inflammatory and infectious diseases. However, the anti-atopic effects of OD are not completely understood yet. Thus, the aim of the present study was to elucidate beneficial effects of OD on atopic dermatitis (AD) in vivo. We examined the pharmacological effects of OD on compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlrobenzene (DNCB)-induced AD-like skin lesions in mice. Additionally, we evaluated regulatory effects of OD on the expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-α in DNCB-induced AD-like skin lesions. Results showed that OD inhibited the scratching behavior and AD symptoms. It also decreased serum levels of IgE and histamine in mice. Moreover, OD significantly ameliorated the expression of IL-6 and TNF-α in AD-like skin lesion. These finding suggest experimental evidence of that OD's potential for treating AD.

Keywords

Acknowledgement

This study was supported by Wonkwang Digital University in 2023.

References

  1. Allam, J.P. and N. Novak. 2006. The pathophysiology of atopic eczema. Clin. Exp. Dermatol. 31:89-93. https://doi.org/10.1111/j.1365-2230.2005.01980.x
  2. Berke, R., A. Singh and M. Guralnick. 2012. Atopic dermatitis: an overview. Am. Fam. Physician. 86: 35-42. 
  3. Bieber, T. 2008. Atopic dermatitis. N. Engl. J. Med. 358:1483-1494.  https://doi.org/10.1056/NEJMra074081
  4. Buske-Kirschbaum, A., A, Geiben and D. Hellhammer. 2001. Psychobiological aspects of atopic dermatitis: an overview. Psychother. Psychosom. 70:6-16.  https://doi.org/10.1159/000056219
  5. Caughey, G,H. 2016. Mast cell proteases as pharmacological targets. Eur. J. Pharmacol. 778:44-55.  https://doi.org/10.1016/j.ejphar.2015.04.045
  6. Fedenko, E.S., O.G. Elisyutina, T.M. Filimonova, M.N. Boldyreva, O.V. Burmenskaya, O.Y. Rebrova, A.A. Yarilin and R.M. Khaitov. 2011. Cytokine gene expression in the skin and peripheral blood of atopic dermatitis patients and healthy individuals. Self Nonself. 2:120-124.  https://doi.org/10.4161/self.2.2.16939
  7. Gupta, S., D. Zhang, J. Yi and J. Shao. 2004. Anticancer activities of Oldenlandia diffusa. J. Herb. Pharmacother. 4:21-33.  https://doi.org/10.1080/J157v04n01_03
  8. Jemima, E.A., A. Prema and E.B. Thangam. 2014. Functional characterization of histamine H4 receptor on human mast cells. Mol. Immunol. 62:19-28.  https://doi.org/10.1016/j.molimm.2014.05.007
  9. Jeon, W.J., J..H. Lee, J.E. Lee, S.E. Son, F. Okajima, K.W. Chung and D.S Im. 2021. Salvianolic acid A suppresses DNCB-induced atopic dermatitis-like symptoms in BALB/c mice. Evid. Based Complement. Alternat. Med. 2021:7902592. 
  10. Kang, D.G, S.J. Park and Y.J. Park. 2021. Target identification of Oldenlandia diffusa extract for anticancer property. Curr. Dev. Nutr. 5:329. 
  11. Kee, J.Y. and S.H. Hong. 2019. Ginsenoside Rg3 suppresses mast cell-mediated allergic inflammation via mitogen-activated protein kinase signaling pathway. J. Ginseng Res. 43:282-290.  https://doi.org/10.1016/j.jgr.2018.02.008
  12. Kim, S.J., Y.G. Kim, D.S Kim, Y.D. Jeon, M.C. Kim, H.L. Kim, S.Y. Kim, H.J. Kim, B.C. Lee, S.H. Hong and J.Y. Um. 2011. Oldenlandia diffusa ameliorates dextran sulphate sodium-induced colitis through inhibition of NF-κB activation. Am. J. Chin. Med. 39:957-969.  https://doi.org/10.1142/S0192415X11009330
  13. Leung, D.Y., M. Boguniewicz, M.D. Howell, I. Nomura and Q.A. Hamid. 2004. New insights into atopic dermatitis. J. Clin. Investig. 113:651-657.  https://doi.org/10.1172/JCI21060
  14. Minami, K. and C. Kamei. 2004. A chronic model for evaluating the itching associated with allergic conjunctivitis in rats. Int. Immunopharmacol. 4:101-108.  https://doi.org/10.1016/j.intimp.2003.10.013
  15. Myung, N.Y. 2020. Adenophorae radix attenuates mast cell-mediated allergic inflammation through down-regulation of NF-κB/ caspase-1 activation. Korean J. Plant Res. 33:659-665. 
  16. Ogata, H. and T. Hibi. 2003. Cytokine and anti-cytokine therapies for inflammatory bowel disease. Curr. Pharm. Des. 9:1107-1113.  https://doi.org/10.2174/1381612033455035
  17. Ovesna, Z, A. Vachalkova, K. Horvathova and D. Tothova. 2004. Pentacyclic triterpenoic acids: new chemoprotective compounds. Minireview. Neoplasma 51:327-333. 
  18. Park, G., H. G. Kim, S.M. Lim, W.M. Lee, Y.M. Sim and M.S. Oh. 2014. Coriander alleviates 2,4-dinitrochlorobenzene-induced contact dermatitis-like skin lesions in mice. J. Med. Food. 17:862-868.  https://doi.org/10.1089/jmf.2013.2910
  19. Saeki, H., M. Furue, F. Furukawa, M. Hide, M. Ohtsuki, I. Katayama, R. Sasaki, H. Suto and K. Takahara 2009. Guidelines for management of atopic dermatitis. J. Dermatol. 36:563-577.  https://doi.org/10.1111/j.1346-8138.2009.00706.x
  20. Sugimoto, M., I. Arai, N. Futaki, Y. Hashimoto, T. Sakurai, Y. Honma and S. Nakaike. 2006. Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Ngamice. Exp. Dermatol. 15:875-882.  https://doi.org/10.1111/j.1600-0625.2006.00480.x
  21. Trefzer, U., M. Hofmann, W. Sterry and K. Asadullah. 2003. Cytokine and anticytokine therapy in dermatology. Expert. Opin. Biol. Ther. 3:733-743.  https://doi.org/10.1517/14712598.3.5.733
  22. Vestergaard, C., K. Bang, B. Gesser, .H Yoneyama, K. Matsushima and C.G. Larsen. 2000. A Th2chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+lymphocytes into lesional atopic dermatitis skin. J. Invest. Dermatol. 115:640-646.  https://doi.org/10.1046/j.1523-1747.2000.00115.x
  23. Wajima, T., Y. Anzai, T. Yamada, H. Ikoshi and N. Noguchi. 2016. Oldenlandia diffusa extract inhibits biofilm formation by haemophilus influenzae clinical isolates. PLoS One 10:1371.