Molecules and Cells

  • 제45권11호
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  • Pages.781-788
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  • 2022
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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Proline Metabolism in Neurological and Psychiatric Disorders

  • Yao, Yuxiao (The Fifth Affiliated Hospital of Guangzhou Medical University) ;
  • Han, Weiping (Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR))
  • 투고 : 2022.07.18
  • 심사 : 2022.09.02
  • 발행 : 2022.11.30
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초록

Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes. Here, we focus our review on proline metabolism in neurons, highlighting the role of dysregulated proline metabolism in neuronal dysfunction and consequently neurological and psychiatric disorders. We will discuss the association between genetic and protein function of enzymes in the proline pathway and the development of neurological and psychiatric disorders. We will conclude with a potential mechanism of proline metabolism in neuronal function and mental health.

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과제정보

Research in the laboratories of W.H. is supported by A*STAR Intramural Funding, the Strategic Research Program (the Brain-Body Initiative) and the Central Research Fund.

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