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A case of primary central nervous system lymphoma diagnosed with cerebrospinal fluid analysis: replacement brain biopsy with cerebrospinal fluid immunohistochemistry and immunoglobulin gene rearrangement

  • Lee, Jun Ho (Department of Neurology, Haeundae Paik Hospital, Inje University of College of Medicine) ;
  • Yu, Shinae (Department of Laboratory Medicine, Haeundae Paik Hospital, Inje University of College of Medicine) ;
  • Lee, Ja Young (Department of Laboratory Medicine, Busan Paik Hospital, Inje University of College of Medicine) ;
  • Kim, Yeon Mee (Department of Pathology, Haeundae Paik Hospital, Inje University of College of Medicine) ;
  • Lee, Dong Ah (Department of Neurology, Haeundae Paik Hospital, Inje University of College of Medicine) ;
  • Kim, Sung Eun (Department of Neurology, Haeundae Paik Hospital, Inje University of College of Medicine)
  • 투고 : 2022.04.28
  • 심사 : 2022.06.13
  • 발행 : 2022.10.30

초록

Primary central nervous system lymphoma (PCNSL) is a type of non-Hodgkin lymphoma confined to the central nervous system. Its diagnosis requires a stereotactic biopsy, which is an invasive procedure. Cerebrospinal fluid (CSF) analysis is less invasive and easier to perform than a stereotactic biopsy. We hereby report a PCNSL case diagnosed using CSF analysis and treated with systemic chemotherapy.

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참고문헌

  1. Grommes C, DeAngelis LM. Primary CNS lymphoma. J Clin Oncol 2017;35:2410-2418. https://doi.org/10.1200/JCO.2017.72.7602
  2. Kleinschmidt-DeMasters BK, Damek DM, Lillehei KO, Dogan A, Giannini C. Epstein Barr virus-associated primary CNS lymphomas in elderly patients on immunosuppressive medications. J Neuropathol Exp Neurol 2008;67:1103-1111. https://doi.org/10.1097/NEN.0b013e31818beaea
  3. Scott BJ, Douglas VC, Tihan T, Rubenstein JL, Josephson SA. A systematic approach to the diagnosis of suspected central nervous system lymphoma. JAMA Neurol 2013;70:311-319. https://doi.org/10.1001/jamaneurol.2013.606
  4. Weller M. Glucocorticoid treatment of primary CNS lymphoma. J Neurooncol 1999;43:237-239. https://doi.org/10.1023/A:1006254518848
  5. Langerak AW, Groenen PJ, Bruggemann M, Beldjord K, Bellan C, Bonello L, et al. EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations. Leukemia 2012;26:2159-2171. https://doi.org/10.1038/leu.2012.246
  6. Ekstein D, Ben-Yehuda D, Slyusarevsky E, Lossos A, Linetsky E, Siegal T. CSF analysis of IgH gene rearrangement in CNS lymphoma: relationship to the disease course. J Neurol Sci 2006;247:39-46. https://doi.org/10.1016/j.jns.2006.03.012
  7. Kros JM, Bagdi EK, Zheng P, Hop WC, Driesse MJ, Krenacs L, et al. Analysis of immunoglobulin H gene rearrangement by polymerase chain reaction in primary central nervous system lymphoma. J Neurosurg 2002;97:1390-1396. https://doi.org/10.3171/jns.2002.97.6.1390
  8. Baehring JM, Hochberg FH, Betensky RA, Longtine J, Sklar J. Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes. J Neurol Sci 2006;247:208-216. https://doi.org/10.1016/j.jns.2006.05.044