Clinical and Experimental Vaccine Research

  • 제11권2호
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  • Pages.141-148
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  • 2022
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  • 2287-3651(pISSN)
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  • 2287-366X(eISSN)
대한백신학회 (The Korean Vaccine Society)
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Possible different genotypes for human papillomavirus vaccination in lower middle-income countries towards cervical cancer elimination in 2030: a cross-sectional study

  • Tofan Widya Utami (Oncology Gynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia) ;
  • Andrijono Andrijono (Oncology Gynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia) ;
  • Andi Putra (Oncology Gynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia) ;
  • Junita Indarti (Social Obstetrics and Gynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia) ;
  • Gert Fleuren (Department of Pathology, Leiden University Medical Center) ;
  • Ekaterina Jordanova (Department of Pathology, Leiden University Medical Center) ;
  • Inas Humairah (Oncology Gynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia) ;
  • Ahmad Utomo (Department of Research and Development, Dharmais Cancer Center)
  • 투고 : 2021.12.19
  • 심사 : 2022.01.26
  • 발행 : 2022.05.31
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초록

Purpose: Human papillomavirus (HPV) genotype and age distribution of HPV infection were crucial for the national vaccination and screening program planning. However, there was a limited study providing these data in the normal cervix population. This study aimed to explore the HPV genotypes profile of women with clinically normal cervix based on Visual Inspection of Acetic Acid (VIA) test. Materials and Methods: A 7-year cross-sectional study was conducted from 2012 to 2018 in private and public health care centers in Jakarta. Subjects were recruited consecutively. Data were collected by anamnesis, VIA, and HPV DNA test using the polymerase chain reaction (PCR; SPF10-DEIA-LiPA25) method. HPV genotyping procedures include DNA extraction, PCR (SPF10-DEIA-LiPA25) using the HPV XpressMatrix kit (PT KalGen DNA, East Jakarta, Indonesia), and hybridization. The IBM SPSS ver. 20.0 (IBM Corp., Armonk, NY, USA) were used to analyze the data. Results: A total of 1,397 subjects were collected. Positive HPV-DNA tests were found in 52 subjects (3.7%); 67% were single and 33% were multiple HPV infections. HPV 52 was the most frequently detected HPV genotype, followed by HPV 39, 16, 18 74, 44, 31, 54, and 66, respectively. The highest HPV infections in this population were in the 31-40 and 41-50 years old group. Conclusion: This study suggested beneficial screening for women aged 31-50 years old. Instead of "original" nonavalent (HPV 16, 18, 6, 11, 31, 33, 45, 52, 58), the different "nonavalent" formula for HPV vaccines protecting against HPV 16, 18, 6, 11, 31, 39, 44, 52, 74 might be useful for Indonesian population. However, further multicenter studies with a huge sample size are still needed.

키워드

과제정보

This research is supported by the Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.

참고문헌

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