Anatomy and Cell Biology

  • 제55권2호
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  • Pages.239-246
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  • 2022
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  • 2093-3665(pISSN)
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  • 2093-3673(eISSN)
대한해부학회 (Korean Association of Anatomists)
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Combination of alpha lipoic acid and metformin supplement improve assisted reproductive technologies outcomes in polycystic ovary syndrome patients

  • Rahil Jannatifar (Department of Reproductive Biology, Academic Center for Education, Culture, and Research (ACECR)) ;
  • Hamid Piroozmanesh (Department of Reproductive Biology, Academic Center for Education, Culture, and Research (ACECR)) ;
  • Seyedeh Saeideh Sahraei (Department of Reproductive Biology, Academic Center for Education, Culture, and Research (ACECR)) ;
  • Elham Asa (Department of Reproductive Biology, Academic Center for Education, Culture, and Research (ACECR))
  • 투고 : 2021.12.09
  • 심사 : 2022.02.14
  • 발행 : 2022.06.30
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초록

We aimed to investigating the effects of metformin (MET) in combination with alpha lipoic acid (ALA) on hormonal and biochemical parameters, in polycystic ovary syndrome (PCOS) women undergoing intracytoplasmic sperm injection (ICSI). This experimental pilot study with a randomized design was carried out on 40 PCOS women in two groups: (1) MET group, administered 1,500 mg/day MET, and (2) MET (1,500 mg/day)+ALA (1,800 mg/day) group. Drugs were administered from the third day of the previous cycle until the day of oocyte aspiration (six weeks of treatment in total). MET+ALA significantly increased the number of maturated oocytes and the rate of fertilization when compared to the MET group. Combination MET+ALA could increase significantly the number of oocytes retrieval and the number of good-quality embryos. Also, the malondialdehyde (MDA) level decreased significantly in the MET+ALA group and the total antioxidant capacity (TAC) level increased significantly in the MET+ALA group compared to the MET group. Also, fasting blood sugar (FBS), insulin, luteinizing hormone (LH), and LH/follicle stimulating hormone (FSH) levels were significantly lower in the MET+ALA group. The pregnancy outcomes showed no significant difference in the rates of biochemical pregnancy, clinical pregnancy, miscarriage, and live births between the control and study groups. The combination of MET+ALA treatment could moderate the complications of PCOS and subsequently improve oocyte and embryo quality.

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과제정보

We would like to thank ACECR center for infertility treatment (Qom branch) for supporting this research project.

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