Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Preliminary Study on Natural Killer Cell Activity for Interfer-on-Gamma Production after Gamma Knife Radiosurgery for Brain Tumors

  • Park, Kawngwoo (Department of Neurosurgery, Gachon University Gil Medical Center) ;
  • Jeong, Sang Soon (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Kim, Jung Hoon (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Chung, Hyun-Tai (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Lee, Eun Jung (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Moon, Hyo Eun (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Park, Kwang Hyon (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Kim, Jin Wook (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Park, Hye Ran (Department of Neurosurgery, Soonchunhyang University Hospital) ;
  • Lee, Jae Meen (Department of Neurosurgery, Pusan National University Hospital) ;
  • Lee, Hye Ja (Department of R & D, NK MAX Company) ;
  • Kim, Hye Rim (Department of R & D, NK MAX Company) ;
  • Cho, Yong Hwan (Department of R & D, NK MAX Company) ;
  • Paek, Sun Ha (Department of Neurosurgery, Seoul National University College of Medicine)
  • Received : 2020.12.08
  • Accepted : 2021.05.14
  • Published : 2022.11.01
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Abstract

Objective : High-dose radiation is well known to induce and modulate the immune system. This study was performed to evaluate the correlation between clinical outcomes and changes in natural killer cell activity (NKA) after Gamma Knife Radiosurgery (GKS) in patients with brain cancer. Methods : We performed an open-label, prospective, cross-sectional study of 38 patients who were treated with GKS for brain tumors, including metastatic and benign brain tumors. All of the patients underwent GKS, and blood samples were collected before and after GKS. NKA was measured using an enzyme-linked immunosorbent assay kit, to measure interferon-gamma (IFNγ) secreted by ex vivo-stimulated NK cells from whole blood. We explored the correlations between NK cell-produced IFNγ (NKA-IFNγ) levels and clinical parameters of patients who were treated with GKS for brain tumors. Results : NKA-IFNγ levels were decreased in metastatic brain tumor patients compared to those with benign brain tumors (p<0.0001). All the patients who used steroid treatment to reduce brain swelling after GKS had an NKA-IFNγ level of zero except one patient. High NKA-IFNγ levels were not associated with a rapid decrease in brain metastasis and did not increase after GKS. Conclusion : The activity of NK cells in metastatic brain tumors decreased more than that in benign brain tumors after GKS.

Keywords

References

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