대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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비알코올 지방간질환에 대한 한의학 연구 동향 보고: 국내 논문을 중심으로

A Review of Research Trends in Traditional Korean Medicine for Nonalcoholic Fatty Liver Disease

  • 김나연 (대구한의대학교 한의과대학 간계내과학교실) ;
  • 윤미정 (대구한의대학교 한의과대학 간계내과학교실) ;
  • 최홍식 (대구한의대학교 한의과대학 간계내과학교실) ;
  • 김승모 (대구한의대학교 한의과대학 간계내과학교실) ;
  • 김상찬 (대구한의대학교 방제학교실) ;
  • 김경순 (대구한의대학교 한의과대학 간계내과학교실)
  • Kim, Na-yeon (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University) ;
  • Yoon, Mi-jung (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University) ;
  • Choi, Hong-sik (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University) ;
  • Kim, Seung-mo (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University) ;
  • Kim, Sang-chan (Dept. of Herbal Formulation, College of Korean Medicine, Daegu Haany University) ;
  • Kim, Kyung-soon (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
  • 투고 : 2022.09.11
  • 심사 : 2022.09.30
  • 발행 : 2022.09.30
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초록

Objectives: The aim of this study was to investigate the trends in research on non-alcoholic fatty liver disease (NAFLD) using Korean traditional medicine. Methods: This review included studies related to the treatment of NAFLD, irrespective of the year of publication. The search terms were "nonalcoholic fatty liver disease", "non-alcoholic fatty liver", "nonalcoholic hepatitis", "herb", "herbal medicine", "acupuncture", and "traditional medicine". The studies were analyzed according to the type of research. Results: After screening, 179 studies were selected from the 592 identified by the search. The types of studies were 151 in vivo or in vitro studies, 5 randomized controlled trials, 12 case reports, 2 unspecified clinical studies, 8 review articles, and 1 article that was difficult to classify. Conclusion: Analysis of the trends in Korean traditional medicine treatment by reviewing the studies on NAFLD revealed a focus on experimental studies rather than clinical studies. Therefore, multifaceted and well-designed studies are needed.

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과제정보

이 논문은 2022년도 정부(과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행된 연구임(No. 2018R1A5A2025272).

참고문헌

  1. Kang SH, Lee HW, Yoo JJ, Cho YR, Kim SU, Lee TH, et al. KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease. Clin Mol Hepatol 2021;27(3):363-401. https://doi.org/10.3350/cmh.2021.0178
  2. Armandi A, Bugianesi E, Valenti L. Natural history of NASH. Liver Int 2021 Jun;41(S1):78-82. https://doi.org/10.1111/liv.14910
  3. Estes C, Chan HLY, Chien RN, Chuang WL, Fung J, Goh GBB, et al. Modelling NAFLD disease burden in four Asian regions-2019-2030. Aliment Pharmacol Ther 2020 Apr;51(8):801-11. https://doi.org/10.1111/apt.15673
  4. Huang DQ, El-Serag HB, Loomba R. Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol 2021 Apr;18(4):223-38. https://doi.org/10.1038/s41575-020-00381-6
  5. Riazi K, Azhari H, Charette JH, Underwood FE, King JA, Afshar EE, et al. The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2022 Sep;7(9):851-61. https://doi.org/10.1016/S2468-1253(22)00165-0
  6. Im HJ, Ahn YC, Wang JH, Lee MM, Son CG. Systematic review on the prevalence of nonalcoholic fatty liver disease in South Korea. Clinics and Research in Hepatology and Gastroenterology 2021 Jul;45(4):101526. https://doi.org/10.1016/j.clinre.2020.06.022
  7. Son CG. Overview of RCT for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. J Korean Oriental Med 2011;32(3):44-9.
  8. Hyun J, Lee JB, Kim SY, Han CW. Clinical Effectiveness of Acupuncture in the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review. J Int Korean Med 2018 Dec 30;39(6):1206-24. https://doi.org/10.22246/jikm.2018.39.6.1206
  9. Kim YK, Jo MJ, Moon YH. Review of Clinical Research about Herbal Medicine Treatment Containing Diuretic Herbs on Non-Alcoholic Fatty Liver Disease - Research on China Academic Journal. J Int Korean Med 2019 Mar 30;40(1):38-57.
  10. Lee YR, Cho NK, Choi HS, Kim SM, Kim KS. A Systematic Review of Korean Medicine for Non-Alcoholic Fatty Liver Disease. J Int Korean Med 2019 Mar 30;40(1):13-37. https://doi.org/10.22246/jikm.2019.40.1.13
  11. Choi MY, Woo HJ, Kim YC, Lee JH. Effects of gamisaenggan-tang on high fat diet-induced nonalcoholic fatty liver disease. J Int Korean Med 2009;30(2):365-74.
  12. Yoo JY, Lee JH. Effects of Saenggantanggami-bang on nonalcoholic fatty liver disease model induced by fatty acids. J Int Korean Med 2010;31(2):331-45.
  13. Kwon SY, Kim KH, Kim YM, Lee IS, Park JY, jeong HS, et al. Effects of Kamichunggantang on Lipoapoptosis and inflammation of NAFLD in db/db mice. Orient Pharm Exp Med 2017 Dec;17(4):365-72. https://doi.org/10.1007/s13596-017-0276-8
  14. Han CW, Lee JH. Effects of KHchunggan-tang on the nonalcoholic fatty liver disease in palmitate-induced cellular model. J Korean Oriental Med 2011;32(1):109-20.
  15. Hong JT, Lee MJ, Yoon SJ, Shin SP, Bang CS, Baik GH, et al. Effect of Korea red ginseng on nonalcoholic fatty liver disease: an association of gut microbiota with liver function. J Ginseng Res 2021 Mar;45(2):316-24. https://doi.org/10.1016/j.jgr.2020.07.004
  16. Han BD, Kim SM, Nam GE, Kim SH, Park SJ, Park YK, et al. A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function. Clin Nutr Res 2020;9(4):258-70. https://doi.org/10.7762/cnr.2020.9.4.258
  17. Jeong JY, Sohn JH, Baek YH, Cho YK, Kim YS, Kim HJ. New botanical drug, HL tablet, reduces hepatic fat as measured by magnetic resonance spectroscopy in patients with nonalcoholic fatty liver disease: A placebo-controlled, randomized, phase II trial. World J Gastroenterol 2017;23(32):5977-85. https://doi.org/10.3748/wjg.v23.i32.5977
  18. Hong MG, Lee YH, Kim SW, Suk KT, Yoon JH, Baik GH, et al. Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease. J Ginseng Res 2016 Jul;40(3):203-10. https://doi.org/10.1016/j.jgr.2015.07.006
  19. Kim DG. Dendropanax Tree Extract for 12 Weeks Having Drunk Non-alcoholic Fatty Liver (NAFLD) Effects of Obesity College Students. Journal of the Korea Entertainment Industry Association 2012 Sep 30;6(3):142. https://doi.org/10.21184/jkeia.2012.09.6.3.142
  20. Kim EJ, Hwang CH, Lee JY, Jang EY, Kim YC, Lee JH. A Case Report of Nonalcoholic Fatty Liver Disease with Obesity and Dyslipidemia. J Int Korean Med 2022 May 31;43(2):184-90. https://doi.org/10.22246/jikm.2022.43.2.184
  21. Gwon GH, Oh SH, Song GJ, Kim SB, Lee HW, Shin HS. A Case Report of a Non-Alcoholic Fatty Liver Disease Patient Treated With Chunggan-tang. J Int Korean Med 2020 Oct 31;41(5):740-4.
  22. Son CG. A juvenile case with nonalcoholic steatohepatitis and traditional Korean medicine -based treatment. Integr Med Res 2018 Jun;7(2):206-9. https://doi.org/10.1016/j.imr.2018.01.006
  23. Kim HY, Joo SH, Bae JH, Jang EG, Kim YC, Lee JH. A Case Report of Nonalcoholic Steatohepatitis with Metabolic Syndrome. J Int Korean Med 2017 May 30;38(2):125-30.
  24. Baik TH. A Case Study on A Patient with Non-Alcoholic Fatty Liver Disease (NAFLD) by Using Ultrasound. J Korean Med 2016 Mar 31;37(1):151-7. https://doi.org/10.13048/jkm.16014
  25. Kang KR, Lee MS, Jung YJ, Choi AR, Han DG, Kang AH, et al. A Case Report of Adolescent Nonalcoholic Fatty Liver Disease (NAFLD) with Obesity. J Int Korean Med 2016 Oct 30;37(5):726-32. https://doi.org/10.22246/jikm.2016.37.5.726
  26. Son CG. A case of non-alcoholic steatohepatitis treated with herbal medicine. J Korean Med 2011;32(3):50-4.
  27. Park KS, Hwang DS, Cho JH, Lee CH, Lee KS. A Case Study on a Patient with Non-alcoholic Fatty Liver Disease (NAFLD) Improved on Sonography by Oriental Obesity Therapy. J Korean Med Obes Res 2009;9(1):79-86.
  28. Choi KH, Kim HY, Song IS. Two Cases Reports of Chlid Fatty Liver with Obesity. J Pediatr Korean Med 2008;22(3):95-103.
  29. Heo JK, Hwang DS, Lee CH, Lee KS. A case study on a Non-alcoholic fatty liver disease (NAFLD) patient improved by the oriental obesity therapy program. J Korean Med Obes Res 2007;7(2):85-94.
  30. Choi BH, Kim DW, Park K, Kim DJ, Byun JS, Hur JI. Case of oriental obesity treatment's effect on improvement of nonalcoholic steatohepatitis patient's liver function. J Physiol & Pathol Korean Med 2006;20(6):1785-8.
  31. Park SM, Lee JH, Seung HS, Lee JH, Woo HJ. A Case of Gagamsaenggan-tang's Effect on Nonalcoholic Steatohepatitis. J of Oriental Chr Dis 2001;7(1):73-7.
  32. Lee JH, Kim D, Kim HJ, Lee CH, Yang JI, Kim W, et al. Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease. Dig Liver Dis 2010 Jul;42(7):503-8. https://doi.org/10.1016/j.dld.2009.08.002
  33. Gwak SR, Shen L, Park SJ, Kwon YM, Joo JC. Clinical Study on Nonalcoholic Fatty Liver Disease Related Factors: Tumor Marker, Heart Rate Variability, Sasang Constitution. J Sasang Constitut Med 2019 Jun 30;31(2):22-30.
  34. Lee SK, Yoon DW, Lee SW, Kim JY, Kim JK, Shin C. Non-alcoholic fatty liver disease among sasang constitutional types: a population-based study in Korea. BMC Complement Altern Med 2015 Dec;15(1):399. https://doi.org/10.1186/s12906-015-0925-8
  35. Choi ES, Jang EY, Lee JH. Pharmacological Activities of Alisma orientale against Nonalcoholic Fatty Liver Disease and Metabolic Syndrome: Literature Review. Evid Based Complement Alternat Med 2019 Jun 3;2019:1-15.
  36. Ko H, Kim KT, Shin SM. Study on Validity of Using Injinho-tang in Non Alcohoic Fatty Liver Disease. Journal of Physiology & Pathology in Korean Medicine 2012;26(6):823-33.
  37. Yoon SJ, Kim SK, Lee NY, Choi YR, Kim HS, Gupta H, et al. Effect of Korean Red Ginseng on metabolic syndrome. J Ginseng Res 2021 May;45(3):380-9. https://doi.org/10.1016/j.jgr.2020.11.002
  38. Park YH, Yoo SR, Son CG. Overview for prevalence and pathology of non-alcoholic fatty liver disease. J Int Korean Med 2011;32(1):26-32.
  39. Kim KT, Ko H, Shin SM. Diagnostic process analysis of prescribing injinho-tang in non alcohoic fatty liver disease using by AHP. The Journal of the Society of Korean Medicine Diagnostics 2015;19(3):159-71.
  40. Choi SY, Park JS, Shon CH, Lee CY, Ryu JM, Son DJ, et al. Fermented Korean Red Ginseng Extract Enriched in Rd and Rg3 Protects against Non-Alcoholic Fatty Liver Disease through Regulation of mTORC1. Nutrients 2019 Dec 4;11(12):2963. https://doi.org/10.3390/nu11122963
  41. Hwang YJ, Wi HR, Kim HR, Park KW, Hwang KA. Pinus densiflora Sieb. et Zucc. Alleviates Lipogenesis and Oxidative Stress during Oleic Acid-Induced Steatosis in HepG2 Cells. Nutrients 2014 Jul 23;6(7):2956-72. https://doi.org/10.3390/nu6072956
  42. Im HJ, Hwang SJ, Lee JS, Lee SB, Kang JY, Son CG. Ethyl Acetate Fraction of Amomum xanthioides Ameliorates Nonalcoholic Fatty Liver Disease in a High-Fat Diet Mouse Model. Nutrients 2020 Aug 13;12(8):2433. https://doi.org/10.3390/nu12082433
  43. Jeon SH, Jang EY, Park GH, Lee YA, Jang YP, Lee KT, et al. Beneficial Activities of Alisma orientale Extract in a Western Diet-Induced Murine Non-Alcoholic Steatohepatitis and Related Fibrosis Model via Regulation of the Hepatic Adiponectin and Farnesoid X Receptor Pathways. Nutrients 2022 Feb 7;14(3):695. https://doi.org/10.3390/nu14030695
  44. Jung SW, Son HW, Hwang CE, Cho KM, Park SW, Kim HJ, et al. The Root of Polygonum multiflorum Thunb. Alleviates Non-Alcoholic Steatosis and Insulin Resistance in High Fat Diet-Fed Mice. Nutrients 2020 Aug 6;12(8):2353. https://doi.org/10.3390/nu12082353
  45. Kim JH, Kim CS, Jo K, Lee IS, Kim JH, Kim JS. POCU1b, the n-Butanol Soluble Fraction of Polygoni Cuspidati Rhizoma et Radix, Attenuates Obesity, Non-Alcoholic Fatty Liver, and Insulin Resistance via Inhibitions of Pancreatic Lipase, cAMP-Dependent PDE Activity, AMPK Activation, and SOCS-3 Suppression. Nutrients 2020 Nov 24;12(12):3612. https://doi.org/10.3390/nu12123612
  46. Kim YJ, Choi JY, Ryu R, Lee JH, Cho SJ, Kwon EY, et al. Platycodon grandiflorus Root Extract Attenuates Body Fat Mass, Hepatic Steatosis and Insulin Resistance through the Interplay between the Liver and Adipose Tissue. Nutrients 2016 Aug 30;8(9):532. https://doi.org/10.3390/nu8090532
  47. Le TNH, Choi HJ, Jun HS. Ethanol Extract of Liriope platyphylla Root Attenuates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice via Regulation of Lipogenesis and Lipid Uptake. Nutrients 2021 Sep 24;13(10):3338.
  48. Lee GH, Lee HY, Park SA, Shin TS, Chae HJ. Eucommia ulmoides Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function. Nutrients 2019 Feb 18;11(2):426. https://doi.org/10.3390/nu11020426
  49. Lee GH, Peng C, Park SA, Hoang TH, Lee HY, Kim JH, et al. Citrus Peel Extract Ameliorates High-Fat Diet-Induced NAFLD via Activation of AMPK Signaling. Nutrients 2020 Mar 1;12(3):673.
  50. Lee MR, Park KI, Ma JY. Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet. Nutrients 2017 Dec 25;10(1):20. https://doi.org/10.3390/nu10010020
  51. Mun JE, Kim ST, Yoon HG, You YH, Kim OK, Choi KC, et al. Water Extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty Liver Disease. Nutrients 2019 Oct 21;11(10):2536. https://doi.org/10.3390/nu11102536
  52. Park HY, Hwang YH, Kim DG, Jeon JW, Ma JY. Hepatoprotective Effect of Herb Formula KIOM2012H against Nonalcoholic Fatty Liver Disease. Nutrients 2015 Apr 2;7(4):2440-55. https://doi.org/10.3390/nu7042440
  53. Park M, Yoo JH, Lee YS, Lee HJ. Lonicera caerulea Extract Attenuates Non-Alcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Hepatocytes and in High Fat Diet-Fed Mice. Nutrients 2019 Feb 26;11(3):494. https://doi.org/10.3390/nu11030494
  54. Seo EH, Oh YS, Jun HS. Psoralea corylifolia L. Seed Extract Attenuates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice. Nutrients 2016 Feb 6;8(2):83. https://doi.org/10.3390/nu8020083
  55. Song YO, Lee SJ, Jang SH, Ha JH, Song YM, Ko YG, et al. Sasa borealis Stem Extract Attenuates Hepatic Steatosis in High-Fat Diet-induced Obese Rats. Nutrients 2014 Jun 5;6(6):2179-95. https://doi.org/10.3390/nu6062179
  56. Tran NKS, Kim GT, Park SH, Lee DY, Shim SM, Park TS. Fermented Cordyceps militaris Extract Prevents Hepatosteatosis and Adipocyte Hypertrophy in High Fat Diet-Fed Mice. Nutrients 2019 May 6;11(5):1015. https://doi.org/10.3390/nu11051015
  57. Chang BY, Kim DS, Kim SY. Improvement in Menopause-Associated Hepatic Lipid Metabolic Disorders by Herbal Formula HPC03 on Ovariectomized Rats. Evid Based Complement Alternat Med 2020 Jul 20;2020:1409376.
  58. Choi DJ, Kim SC, Park GE, Choi BR, Lee DY, Lee YS, et al. Protective Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract against Hepatic Steatosis in High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mice. Evid Based Complement Alternat Med 2020 Mar 19;2020:1-11
  59. Jung HY, Kim YH, Kim IB, Jeong JS, Lee JH, Do MS, et al. The Korean Mistletoe (Viscum album coloratum) Extract Has an Antiobesity Effect and Protects against Hepatic Steatosis in Mice with High-Fat Diet-Induced Obesity. Evid Based Complement Alternat Med 2013; 2013:1-9.
  60. Kim HG, Lee SB, Lee JS, Kim WY, Choi SH, Son CG. Artemisia iwayomogi plus Curcuma longa Synergistically Ameliorates Nonalcoholic Steatohepatitis in HepG2 Cells. Evid Based Complement Alternat Med 2017;2017:1-9.
  61. Lee YY, Kim M, Irfan M, Yuk HJ, Kim DS, Lee SE, et al. Ulmus parvifolia Jacq. Exhibits Antiobesity Properties and Potentially Induces Browning of White Adipose Tissue. Krishnan UM, editor. Evid Based Complement Alternat Med 2020 Dec 23;2020:1-14.
  62. Lim DW, Kim H, Lee SJ, Yu GR, Kim JE, Park WH. Jwa Kum Whan Attenuates Nonalcoholic Fatty Liver Disease by Modulating Glucose Metabolism and the Insulin Signaling Pathway. Evid Based Complement Alternat Med 2019 Feb 10;2019:1-10.
  63. Na HY, Seol MH, Kim M, Lee BC. Effect of Seyoeum on Obesity, Insulin Resistance, and Nonalcoholic Fatty Liver Disease of High-Fat Diet-Fed C57BL/6 Mice. Evid Based Complement Alternat Med 2017;2017:1-8.
  64. Yang DK, Jo DG. Mulberry Fruit Extract Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) through Inhibition of Mitochondrial Oxidative Stress in Rats. Evid Based Complement Alternat Med 2018 Dec 13;2018:1-9.
  65. Jang MK, Nam JS, Kim JH, Yun YR, Han CW, Kim BJ, et al. Schisandra chinensis extract ameliorates nonalcoholic fatty liver via inhibition of endoplasmic reticulum stress. J Ethnopharmacol 2016 Jun;185:96-104. https://doi.org/10.1016/j.jep.2016.03.021
  66. Jung HJ, Cho KH, Kim SY, Seong JK, Oh SH. Ethanol extract of Pharbitis nil ameliorates liver fibrosis through regulation of the TGFβ 1-SMAD2/3 pathway. J Ethnopharmacol 2022 Aug;294:115370. https://doi.org/10.1016/j.jep.2022.115370
  67. Lim JH, Lee HR, Ahn JW, Kim JJ, Jang JS, Park YH, et al. The polyherbal drug GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits hepatic steatosis and fibroinflammtion in high-fat diet-induced obese mice. J Ethnopharmacol 2018 Oct;225:31-41. https://doi.org/10.1016/j.jep.2018.06.034
  68. Park SH, Lee JE, Lee SM, Lee JE, Seo CS, Hwang GS, et al. An unbiased lipidomics approach identifies key lipid molecules as potential therapeutic targets of Dohongsamul-tang against non-alcoholic fatty liver diseases in a mouse model of obesity. J Ethnopharmacol 2020 Oct; 260:112999. https://doi.org/10.1016/j.jep.2020.112999
  69. Roh JS, Lee HR, Lim JH, Kim JJ, Yang HJ, Yoon YS, et al. Effect of Gangjihwan on hepatic steatosis and inflammation in high fat diet-fed mice. J Ethnopharmacol 2017 Jul;206:315-26. https://doi.org/10.1016/j.jep.2017.06.008
  70. Seo MS, Hong SW, Yeon SH, Kim YM, Um KA, Kim JH, et al. Magnolia officinalis attenuates free fatty acid-induced lipogenesis via AMPK phosphorylation in hepatocytes. J Ethnopharmacol. 2014 Nov;157:140-8. https://doi.org/10.1016/j.jep.2014.09.031
  71. Shin SS, Yoon MC. Korean red ginseng (Panax ginseng) inhibits obesity and improves lipid metabolism in high fat diet-fed castrated mice. J Ethnopharmacol 2018 Jan;210:80-7. https://doi.org/10.1016/j.jep.2017.08.032
  72. Bae UJ, Park EO, Park J, Jung SJ, Ham HM, Yu KW, et al. Gypenoside UL4-Rich Gynostemma pentaphyllum Extract Exerts a Hepatoprotective Effect on Diet-Induced Nonalcoholic Fatty Liver Disease. Am J Chin Med 2018 Jan;46(06):1315-32. https://doi.org/10.1142/S0192415X18500696
  73. Jeong HE, Kim JW, Yang MS, Park C, Kim JH, Lim CW, et al. Beneficial Effects of Korean Red Ginseng in the Progression of Non-Alcoholic Steatohepatitis via FABP4 Modulation. Am J Chin Med 2018 Jan;46(07):1581-607. https://doi.org/10.1142/S0192415X18500817
  74. Lee HY, Lee GH, Yoon Y, Chae HJ. Rhus verniciflua and Eucommia ulmoides Protects Against High-Fat Diet-Induced Hepatic Steatosis by Enhancing Anti-Oxidation and AMPK Activation. Am J Chin Med 2019 Jan;47(06):1253-70. https://doi.org/10.1142/S0192415X19500642
  75. Lee MR, Lee HY, Lee GH, Kim HK, Kim NY, Kim SH, et al. Ixeris dentata Decreases ER Stress and Hepatic Lipid Accumulation through Regulation of ApoB Secretion. Am J Chin Med 2014 Jan;42(03):639-49. https://doi.org/10.1142/S0192415X14500414
  76. Oh GS, Yoon J, Lee GG, Kwak JH, Kim SW. The Hexane Fraction of Cyperus rotundus Prevents Non-Alcoholic Fatty Liver Disease Through the Inhibition of Liver X Receptor Ⓡ-Mediated Activation of Sterol Regulatory Element Binding Protein-1c. Am J Chin Med 2015 Jan;43(03):477-94. https://doi.org/10.1142/S0192415X15500305
  77. Hwang KA, Hwang YJ, Kim GR, Choe JS. Extracts from Aralia elata (Miq) Seem alleviate hepatosteatosis via improving hepatic insulin sensitivity. BMC Complement Altern Med 2015 Dec;15(1):347. https://doi.org/10.1186/s12906-015-0871-5
  78. Jang EY, Shin MH, Kim KS, Kim YM, Na YC, Woo HJ, et al. Anti-lipoapoptotic effect of Artemisia capillaris extract on free fatty acids-induced HepG2 cells. BMC Complement Altern Med 2014 Dec;14(1):253. https://doi.org/10.1186/1472-6882-14-253
  79. Lee MR, Kim JE, Park JW, Kang MJ, Choi HJ, Bae SJ, et al. Fermented mulberry (Morus alba) leaves suppress high fat diet-induced hepatic steatosis through amelioration of the inflammatory response and autophagy pathway. BMC Complement Med Ther 2020 Dec;20(1):283. https://doi.org/10.1186/s12906-020-03076-2
  80. Son YJ, Jung DS, Shin JM, Kim MS, Yoo GH, Nho CW. Yellow loosestrife (Lysimachia vulgaris var. davurica) ameliorates liver fibrosis in db/db mice with methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis. BMC Complement Med Ther 2021 Dec;21(1):44. https://doi.org/10.1186/s12906-021-03212-6
  81. Choi JY, Kim SY, Kwun MJ, Kim KH, Joo MS, Han CW. Effects of ethanol extract of Benincasa seeds on the experimental cellular model of nonalcoholic fatty liver disease. J Int Korean Med 2012;33(4):438-47.
  82. Han CW, Joo MS, Lee JH. Comparison of the therapeutic efficacy of rhizoma alismatis, fructus crataegi, fructus lycii, radix curcumae, radix salviae miltiorrhizae, herba artemisiae scopariae on the experimental cellular model of nonalcoholic fatty liver disease. J Int Korean Med 2012;33(4):533-42.
  83. Kim EY, Lee JH. The effect of alisma orientale extract on free fatty acid-induced lipoapoptosis in HepG2 cells. J Int Korean Med 2014;35(2):184-94.
  84. Kim SY, Kwon JN, Lee I, Hong JW, Choi JY, Park SH, et al. Research on anti-lipogenic effect and underlying mechanism of Laminaria japonica on experimental cellular model of non-alcoholic fatty liver disease. J Int Korean Med 2014;35(2):175-83.
  85. Lee HI, Kim YK, Lim HC, Lee DE, Kim EJ, Moon YH. Effects of Agastachis Herba Extract and Lysimachiae Herba Extract on the Experimental Cellular Model of NFLDs Induced by Palmitic Acid. J Int Korean Med 2018 Jun 30;39(3):302-12. https://doi.org/10.22246/jikm.2018.39.3.302
  86. Lee JW, Choi CW, Jeon SY, Han CW, Ha YJ. Effect of Jungmanbunso-hwan extract on HepG2 cell model of nonalcoholic fatty liver disease caused by palmitate. J Int Korean Med 2016;37(3):442-52.
  87. Yun KS, Woo HJ, Lee JH, Kim YC. Effect of Injinchunggan-tang & Injinsaryung-san on NASH induced by MCD-diet in A/J mice. J Int Korean Med 2009;30(2):410-21.
  88. Choi EY, Choi JO, Park CY, Kim SH, Kim DH. Water Extract of Artemisia annua L. Exhibits Hepatoprotective Effects Through Improvement of Lipid Accumulation and Oxidative Stress-Induced Cytotoxicity. J Med Food 2020 Dec 1;23(12):1312-22. https://doi.org/10.1089/jmf.2020.4696
  89. Choi JY, Kwon EY, Choi MS. Elucidation of the Metabolic and Transcriptional Responses of an Oriental Herbal Medicine, Bangpungtongseong-san, to Nonalcoholic Fatty Liver Disease in DietInduced Obese Mice. J Med Food 2019 Sep 1;22(9):928-36. https://doi.org/10.1089/jmf.2018.4383
  90. Chung MY, Mah E, Masterjohn C, Noh SK, Park HJ, Clark RM, et al. Green Tea Lowers Hepatic COX-2 and Prostaglandin E2 in Rats with Dietary Fat-Induced Nonalcoholic Steatohepatitis. J Med Food 2015 Jun;18(6):648-55. https://doi.org/10.1089/jmf.2014.0048
  91. Chung YH, Bang JS, Kang CM, Goh JW, Lee HS, Hong SM, et al. Aqueous Extract of Humulus japonicus Attenuates Hyperlipidemia and Fatty Liver in Obese Mice. J Med Food 2018 Oct;21(10):999-1008. https://doi.org/10.1089/jmf.2017.4135
  92. Davaatseren M, Hur HJ, Yang HJ, Hwang JT, Park JH, Kim HJ, et al. Dandelion Leaf Extract Protects Against Liver Injury Induced by Methionine- and Choline-Deficient Diet in Mice. J Med Food 2013 Jan;16(1):26-33. https://doi.org/10.1089/jmf.2012.2226
  93. Im AR, Kim YH, Kim YH, Yang WK, Kim SH, Song KH. Dolichos lablab Protects Against Nonalcoholic Fatty Liver Disease in Mice Fed High-Fat Diets. J Med Food 2017 Dec;20(12):1222-32. https://doi.org/10.1089/jmf.2017.4036
  94. Im AR, Kim YH, Lee HW, Song KH. Water Extract of Dolichos lablab Attenuates Hepatic Lipid Accumulation in a Cellular Nonalcoholic Fatty Liver Disease Model. J Med Food 2016 May;19(5):495-503. https://doi.org/10.1089/jmf.2015.3623
  95. Mun JE, Park JJ, Yoon HG, You YH, Choi KC, Lee YH, et al. Effects of Eriobotrya japonica Water Extract on Alcoholic and Nonalcoholic Fatty Liver Impairment. J Med Food 2019 Dec 1;22(12):1262-70. https://doi.org/10.1089/jmf.2019.4493
  96. Park K, Yoon HJ, Imm JY, Go G woong. Hovenia dulcis Extract Attenuates High-Fat Diet-Induced Hepatic Lipid Accumulation and Hypertriglyceridemia in C57BL/6 Mice. J Med Food 2019 Jan;22(1):74-80. https://doi.org/10.1089/jmf.2018.4224
  97. Ryu R, Kim HJ, Moon BS, Jung UJ, Lee MK, Lee DG, et al. Ethanol Extract of Persimmon Tree Leaves Improves Blood Circulation and Lipid Metabolism in Rats Fed a High-Fat Diet. J Med Food 2015 Jul;18(7):715-23. https://doi.org/10.1089/jmf.2014.3307
  98. Tran NKS, Kim GT, Lee DY, Kim YJ, Park HJ, Park DK, et al. Fermented Cordyceps militaris Extract Ameliorates Hepatosteatosis via Activation of Fatty Acid Oxidation. J Med Food. 2019 Apr;22(4):325-36. https://doi.org/10.1089/jmf.2018.4245
  99. Choi NE, Kim JW, Jeong H, Shin DG, Seo JH, Kim JH, et al. Fermented ginseng, GBCK25, ameliorates steatosis and inflammation in nonalcoholic steatohepatitis model. J Ginseng Res 2019 Apr;43(2):196-208. https://doi.org/10.1016/j.jgr.2017.10.002
  100. Kim GW, Jo HK, Chung SH. Ginseng seed oil ameliorates hepatic lipid accumulation in vitro and in vivo. J Ginseng Res 2018 Oct;42(4):419-28. https://doi.org/10.1016/j.jgr.2017.04.010
  101. Kim MH, Lee JS, Jung SH, Kim JW, Shin JH, Lee HJ. The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet. J Ginseng Res 2017 Apr;41(2):120-6. https://doi.org/10.1016/j.jgr.2016.01.004
  102. Park M, Yoo JH, Lee YS, Park EJ, Lee HJ. Ameliorative effects of black ginseng on nonalcoholic fatty liver disease in free fatty acid-induced HepG2 cells and high-fat/high-fructose diet-fed mice. J Ginseng Res 2020 Mar;44(2):350-61. https://doi.org/10.1016/j.jgr.2019.09.004
  103. Yang DR, Jeong H, Hwang SM, Kim JW, Moon HW, Lee YE, et al. Oral administration of Jinan Red Ginseng and licorice extract mixtures ameliorates nonalcoholic steatohepatitis by modulating lipogenesis. J Ginseng Res 2022 Jan;46(1):126-37. https://doi.org/10.1016/j.jgr.2021.05.006
  104. Ahn YJ, Yoon KH, Jo JH, Jang DH, Jung YS, Kim JH, et al. Gangjihwan Improves Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed C57BL/6N Mice. Kor J Herbol 2014 Mar 30;29(2):47-54. https://doi.org/10.6116/kjh.2014.29.2.47
  105. Hwang HC, Kong R, Kang OH, Kwo DY. Hepatoprotecive Effects of Puerariae Flos Extract on Experimental Non-alcoholic Fatty Liver Disease Models. Kor J Herbol 2018 Sep 30;33(5):1-8.
  106. Kim MC, Kong R, Han HS, Kang DH, Lee SJ, Lee CC, et al. Non-alcoholic fatty liver protective effects, and studies on the mechanism of action of Crataegi Fructus. Kor J Herbol 2018 Nov 30;33(6):61-70.
  107. Roh JS, Lee HR, Ahn YJ, Yoon MC, Shin SS. Massa Medicata Fermentata improves fatty liver in high fat diet-fed nonalcoholic fatty liver disease's mouse model. Kor J Herbol 2014 Mar 30;29(2):23-31.
  108. Shin SS, Yoon MC, Tsung PC, Lee YT. Gambigyeongsinhwan(1) Improves Body Weight and Lipid Metabolism in High Fat Diet-Fed Obese Animal Model. Kor J Herbol 2014 Jan 30;29(1):35-43.
  109. Jang DH, Jung YS, Kim JH, Kim BC, Seok HJ, Yoo JS, et al. Comparison of Gangjihwan and Combination of Gangjihwan and Gamisochehwan in the Improvement Effects of Nonalcoholic Fatty Liver Disease in a High Fat Diet-Fed NAFLD Mouse Model. Herbal Formula Science 2014 Jun 30;22(1):167-76. https://doi.org/10.14374/HFS.2014.22.1.167
  110. Jo JH, Jang DH, Jung YS, Kim JH, Kim BC, Seok HJ, et al. Comparison of Pakistani and Chinese Ephedra Herba-Containing Gangjihwan in the Improvement Effects of Nonalcoholic Fatty Liver Disease in a High Fat Diet-Fed NAFLD Mouse Model. Herbal Formula Science 2014 Jun 30;22(1):113-22. https://doi.org/10.14374/HFS.2014.22.1.113
  111. Kim JK, Cho IJ, Kim EO, Jung DH, Ku SK, Kim SC. The effects of Hemistepta lyrata Bunge (Bunge) fractionated extract on liver X receptor α-dependent lipogenic genes in hepatocyte-derived cells. Herbal Formula Science 2020 Aug 31;28(3):255-69. https://doi.org/10.14374/HFS.2020.28.3.255
  112. Lee HI, Kim JS, Kim CJ, Kim HN, Yang TJ, Jeong SJ, et al. Research on Anti-lipogenic Effect of Sobuncheong-eum on Experimental Cellular Model of Non-alcoholic Fatty Liver Disease. Herbal Formula Science 2016 May 31;24(2):100-7. https://doi.org/10.14374/HFS.2016.24.2.100
  113. Lee JY, Kook YB. Effects of Samhwangsasim-tang on obesity-related metabolic disease in mice. Herbal Formula Science 2014 Jun 30;22(1):93-104. https://doi.org/10.14374/HFS.2014.22.1.093
  114. Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J. Harrison's Principles of Internal Medicine. 19th edition. Seoul: MIP; 2017.
  115. Hallsworth K, Adams LA. Lifestyle modification in NAFLD/NASH: Facts and figures. JHEP Rep 2019 Dec;1(6):468-79. https://doi.org/10.1016/j.jhepr.2019.10.008
  116. Langford CR, Goldinger MH, Treanor D, McGenity C, Dillman JR, Allende DS, et al. Improved pathology reporting in NAFLD/NASH for clinical trials. J Clin Pathol 2022 Feb;75(2):73-5. https://doi.org/10.1136/jclinpath-2021-207967
  117. Li B, Fang L. Research Progress on the Mechanism of Acupuncture Treatment for Nonalcoholic Fatty Liver Disease. Zhao E, editor. Gastroenterol Res Pract 2022 Jun 22;2022:1-8.
  118. Liang Z, Chen X, Shi J, Hu H, Xue Y, Ung COL. Efficacy and safety of traditional Chinese medicines for non-alcoholic fatty liver disease: a systematic literature review of randomized controlled trials. Chin Med 2021 Dec;16(1):9. https://doi.org/10.1186/s13020-020-00422-x
  119. Xu Y, Guo W, Zhang C, Chen F, Tan HY, Li S, et al. Herbal Medicine in the Treatment of Non-Alcoholic Fatty Liver Diseases-Efficacy, Action Mechanism, and Clinical Application. Front Pharmacol 2020 May 12;11:601.
  120. Shi KQ, Fan YC, Liu WY, Li LF, Chen YP, Zheng MH. Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis. Mol Biol Rep 2012 Oct;39(10):9715-22. https://doi.org/10.1007/s11033-012-1836-0
  121. Chen P, Zhong X, Dai Y, Tan M, Zhang G, Ke X, et al. The efficacy and safety of acupuncture in nonalcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials. Medicine 2021 Sep 24;100(38):e27050. https://doi.org/10.1097/MD.0000000000027050
  122. Yan T, Yan N, Wang P, Xia Y, Hao H, Wang G, et al. Herbal drug discovery for the treatment of nonalcoholic fatty liver disease. Acta Pharmaceutica Sinica B 2020 Jan;10(1):3-18. https://doi.org/10.1016/j.apsb.2019.11.017
  123. Baek SY, Lee HR, Park JH, Yoon MC, Yoon YS, Yang HJ, et al. Gangjihwan Reduces Body Weight Gain in a ob/ob Female Mice. Herbal Formula Science 2017 May 31;25(2):193-207. https://doi.org/10.14374/HFS.2017.25.2.193
  124. Lee SN, Leem KH, Ju YS, Son JB, Kim HJ. The literatual study of Kamisoyo-san on menopausal disorder. The Journal of Korean Obstetrics and Gynecology 2009;22(4):46-64. https://doi.org/10.15204/JKOBGY.2009.22.4.046
  125. Clark JM, Brancati FL, Diehl AM. Nonalcoholic fatty liver disease. Gastroenterology 2002;122(6):1649-57. https://doi.org/10.1053/gast.2002.33573
  126. Go H, Ryuk JA, Hwang JT, Ko BS. Effects of three different formulae of Gamisoyosan on lipid accumulation induced by oleic acid in HepG2 cells. Integr Med Res 2017 Dec;6(4):395-403. https://doi.org/10.1016/j.imr.2017.08.004
  127. Ahn SH, Yang ES, Cho HR, Lee SO, Ha KT, Kim KB. Herbal formulation MIT ameliorates high-fat diet-induced non-alcoholic fatty liver disease. Integr Med Res 2020 Dec;9(4):100422. https://doi.org/10.1016/j.imr.2020.100422
  128. Kim KB, Ahn SH. The Efficacy of Ephedra sinica, Panax ginseng, and Alisma orientale Extract on Insulin resistance induced by Non-alcoholic fatty liver disease (NAFLD). J Pediatr Korean Med 2020 Nov 30;34(4):11-21.
  129. Goyale A, Jain A, Smith C, Papatheodoridi M, Misas MG, Roccarina D, et al. Assessment of non-alcoholic fatty liver disease (NAFLD) severity with novel serum-based markers: A pilot study. Strnad P, editor. PLoS ONE 2021 Nov 23;16(11):e0260313. https://doi.org/10.1371/journal.pone.0260313
  130. Diep Nguyen T. Adiponectin: Role in physiology and pathophysiology. Int J Prev Med 2020;11(1):136. https://doi.org/10.4103/ijpvm.IJPVM_193_20
  131. Woo HJ, Lee JH, Kim YC, Kim GS, Son CK, Jo JH. Oriental Internal Medicine on Hepatobiliary System, Hematology and Toxicology 6th. Seoul: Nado; 2016, p. 307-12.
  132. Hwang SJ, Choi HS, Kim SM, Woo CH. Effects of Saengkankeonbi-tang on prevention of hyperlipidemia and liver damage induced by alcohol. Kor J Herbol 2009;24(4):9-16.
  133. Lee IW, Choi HY, Lee JH, Park SD, Kim SM, Ku SK, et al. Saeng-Kankunbi-Tang (生肝健脾汤) protects liver against oxidative damage through activation of ERK/Nrf2 pathway. Chin J Integr Med 2016 Aug;22(8):619-28. https://doi.org/10.1007/s11655-016-2466-5
  134. Joung JY, Kim HG, Lee JS, Cho JH, Ahn YC, Lee DS, et al. Anti-hepatofibrotic effects of CGX, a standardized herbal formula: A multicenter randomized clinical trial. Biomedicine & Pharmacotherapy 2020 Jun;126:110105. https://doi.org/10.1016/j.biopha.2020.110105
  135. Kim HG, Han JM, Lee HW, Lee JS, Son SW, Choi MK, et al. CGX, a multiple herbal drug, improves cholestatic liver fibrosis in a bile duct ligation-induced rat model. Journal of Ethnopharmacology 2013 Jan;145(2):653-62. https://doi.org/10.1016/j.jep.2012.12.005
  136. Shin JW, Park HJ, Kwon M, Son CG. Scientific evaluation of the chronic toxicity of the herbal medicine CGX in beagle dogs. Food Chem Toxicol 2010 Feb;48(2):743-9. https://doi.org/10.1016/j.fct.2009.12.008
  137. Shin JW, Wang JH, Kim HG, Park HJ, Bok HS, Son CG. CGX, a traditional Korean medicine ameliorates concanavalin A-induced acute liver injury. Food Chem Toxicol 2010 Dec;48(12):3308-15. https://doi.org/10.1016/j.fct.2010.08.025
  138. Kim HG. Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model. World J Gastroenterol 2014;20(42):15703-14. https://doi.org/10.3748/wjg.v20.i42.15703
  139. Song SM, Song YK, Lim HH. The effect of electroacupuncture on abdominal fat deposit and parameters for obesity. J Exerc Rehabil 2010;20(2):113-27.
  140. Canbay A, Kalsch J, Neumann U, Rau M, Hohenester S, Baba HA, et al. Non-invasive assessment of NAFLD as systemic disease-A machine learning perspective. Strnad P, editor. PLoS ONE 2019 Mar 26;14(3):e0214436. https://doi.org/10.1371/journal.pone.0214436
  141. Kim MJ, Bae HS, Park SS. Study on Liver Function Test and Liver Disorders under the Ultrasonography for each of the Sasang Constitutional Types. J Sasang Constitut Med 2013 Sep 30;25(3):195-207. https://doi.org/10.7730/JSCM.2013.25.3.195
  142. Choi JY, Lee KH, Lee SM, Yoo SH, Hwang SG, Choi JY, et al. Efficacy and Safety of Human Pla-cental Extract for Alcoholic and Nonalcoholic Steatohepatitis: An Open-Label, Randomized, Comparative Study. Biological & Pharmaceutical Bulletin 2014;37(12):1853-9. https://doi.org/10.1248/bpb.b13-00979