The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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East Asian Traditional Medicine Treatment for Patients after Heart Valve Replacements: A Systematic Review with Meta-Analysis

심장판막 치환술 후 한의학적 치료에 대한 체계적 문헌고찰 및 메타분석

  • Ahn, Mu-hyeok (Pusan National University School of Korean Medicine) ;
  • Kim, Ji-ho (Pusan National University School of Korean Medicine) ;
  • Shin, Bong-jin (Pusan National University School of Korean Medicine) ;
  • Kwon, Jung-nam (Dept. of Internal Medicine of Korean Medicine, Pusan University Korean Medicine Hospital)
  • 안무혁 (부산대학교 한의학전문대학원) ;
  • 김지호 (부산대학교 한의학전문대학원) ;
  • 신봉진 (부산대학교 한의학전문대학원) ;
  • 권정남 (부산대학교한방병원 한방내과)
  • Received : 2022.09.14
  • Accepted : 2022.10.05
  • Published : 2022.09.30
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Abstract

Objectives: To compare the effectiveness and safety of East Asian traditional medicine treatments (EATMT) versus conventional management in patients following heart valve replacement surgery. Methods: We searched several databases, including the Korean Studies Information Service System, PubMed, China National Knowledge Infrastructure, and Citation Information by NII. The search range included randomized controlled trials from each first issue until June 27, 2021. Two review authors independently extracted the data. We assessed the risk of systematic errors by evaluating risk domains using the "Risk of bias" tool. Results: We included 5 trials in the review. In the EATMT, the investigators reported significant improvements in reshaping of the heart structure: left ventricular end diastolic diameter (MD -4.43, 95% CI -6.06 to -2.79; 130 participants; 2 studies; high evidence). Comparisons with usual care revealed a significant decrease in gastrointestinal complications rate (OR 0.30, 95% CI 0.20 to 0.47; 503 participants; 2 studies; high evidence). We assessed 4 studies as having a low risk of bias and 1 study as having a high risk of bias. Conclusion: This systematic review suggests that East Asian traditional medicine interventions may be effective in preventing and alleviating complications, but we found evidence of important trade-offs between known benefits and known adverse effects in cardiac dysfunction and inflammation following heart valve replacement. Consequently, additional high-quality studies should be conducted.

Keywords

Acknowledgement

본 연구는 2021년도 부산대학교 병원 임상연구비 지원으로 이루어졌습니다.

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