Clinical Nutrition Research

The Korean Society of Clinical Nutrition (한국임상영양학회)
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The Effect of Green Coffee Supplementation on Lipid Profile, Glycemic Indices, Inflammatory Biomarkers and Anthropometric Indices in Iranian Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial

  • Mehrnoush Meshkani (Department of Nutrition Science, Science and Research Branch, Faculty of Medical Sciences and Technologies, Islamic Azad University) ;
  • Ahmad Saedisomeolia (Department of Nutrition Science, Science and Research Branch, Faculty of Medical Sciences and Technologies, Islamic Azad University) ;
  • Mirsaeed Yekaninejad (Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences) ;
  • Seyed Ahmad Mousavi (Department of Nutrition Science, Science and Research Branch, Faculty of Medical Sciences and Technologies, Islamic Azad University) ;
  • Azam Ildarabadi (Department of Nutrition Science, Science and Research Branch, Faculty of Medical Sciences and Technologies, Islamic Azad University) ;
  • Marzieh Vahid-Dastjerdi (Department of Obstetrics and Gynecology, School of Medicine, Tehran University of Medical Sciences)
  • Received : 2022.07.12
  • Accepted : 2022.10.10
  • Published : 2022.10.31
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Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous clinical syndrome. Recent studies examine different strategies to modulate its related complications. Chlorogenic acid, as a bioactive component of green coffee (GC), is known to have great health benefits. The present study aimed to determine the effect of GC on lipid profile, glycemic indices, and inflammatory biomarkers. Forty-four PCOS patients were enrolled in this randomized clinical trial of whom 34 have completed the study protocol. The intervention group (n = 17) received 400 mg of GC supplements, while the placebo group (n = 17) received the same amount of starch for six weeks. Then, glycemic indices, lipid profiles, and inflammatory parameters were measured. After the intervention period, no significant difference was shown in fasting blood sugar, insulin level, Homeostasis model assessment of insulin resistance index, low-density lipoprotein, high-density lipoprotein, Interleukin 6 or 10 between supplementation and placebo groups. However, cholesterol and triglyceride serum levels decreased significantly in the intervention group (p < 0.05). This research confirmed that GC supplements might improve some lipid profiles in women with PCOS. However, more detailed studies with larger sample sizes are required to prove the effectiveness of this supplement.

Keywords

Acknowledgement

We would like to express our special thanks to all of the participating patients in this project.

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