Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Melanocytotoxic chemicals and their toxic mechanisms

  • Received : 2022.05.06
  • Accepted : 2022.06.27
  • Published : 2022.10.15
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Abstract

Melanocyte cell death can lead to various melanocyte-related skin diseases including vitiligo and leukoderma. Melanocytotoxic chemicals are one of the most well-known causes of nongenetic melanocyte-related diseases, which induce melanocyte cell death through apoptosis. Various chemicals used in cosmetics, medicine, industry and food additives are known to induce melanocyte cell death, which poses a significant risk to the health of consumers and industrial workers. This review summarizes recently reported melanocytotoxic chemicals and their mechanisms of toxicity in an effort to provide insight into the development of safer chemicals.

Keywords

Acknowledgement

This work was supported by the Grants from National Research Foundation of Korea (NRF-2020R1I1A1A01067636) and Ministry of Science and ICT (MSIT) (2018R1A5A2025286).

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