Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Emerging Japanese Encephalitis Virus Genotype V in Republic of Korea

  • Lee, Ah-Ra (Department of Biomedicine and Health Sciences, Department of Microbiology, College of Medicine, The Catholic University of Korea) ;
  • Song, Jae Min (School of Biopharmaceutical and Medical Sciences, Sungshin Women's University) ;
  • Seo, Sang-Uk (Department of Biomedicine and Health Sciences, Department of Microbiology, College of Medicine, The Catholic University of Korea)
  • Received : 2022.07.05
  • Accepted : 2022.07.21
  • Published : 2022.08.28
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Abstract

Japanese encephalitis (JE) is a vaccine-preventable mosquito-borne disease caused by infection with the Japanese encephalitis virus (JEV). JEV has five genotypes, including genotype V (GV), which is considered ancestral to the other genotypes. The first GV strain, GV Muar, was isolated from a Malayan patient in 1952 and GV did not reappear for 57 years until GV XZ0934 was isolated from a mosquito sample in China. Since 2010, 21 GV strains have been identified in Republic of Korea (ROK). Both GV Muar and GV XZ0934 are more pathogenic than other GI/GIII strains and are serologically distinct. However, because the ROK's GV strains have not been experimentally tested, their characteristics are not known. Characterization of the ROK's isolates is needed to enable development of effective GV strain-based vaccines to protect against GV infections.

Keywords

Acknowledgement

This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2022R1F1A1074547) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare (HV22C0235), Republic of Korea.

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