Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Natural Product-Based Products for Sleep Improvement: Analysis of Patent Status in Korea

불면증 관련 천연물 추출물의 특허 동향 분석

  • Lee, Jung-Gyung (Department of Korean Medicine, Dong-Eui University College of Korean Medicine) ;
  • Kang, Sung-Hyun (Department of Korean Medicine, Dong-Eui University College of Korean Medicine) ;
  • Kwon, Chan-Young (Department of Oriental Neuropsychiatry, Dong-Eui University College of Korean Medicine)
  • 이정경 (동의대학교 한의과대학 한의학과) ;
  • 강성현 (동의대학교 한의과대학 한의학과) ;
  • 권찬영 (동의대학교 한의과대학 한방신경정신과)
  • Received : 2022.09.02
  • Accepted : 2022.09.15
  • Published : 2022.09.30
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Abstract

Objectives: The purpose of this study was to analyze the trend of natural product-based products for sleep improvement in Korean patents, to enhance the development and application of natural-products for sleep disorder in terms of Korean medicine. Methods: We collected patent data using the KIPRIS database and ScienceON database. Two authors independently screened patents that potentially met the criteria, and assessed full texts of screened patents for eligibility. Included patents were analyzed, quantitatively as well as qualitatively. Results: A total of 60 patents were selected 2008-July 2022. The number of patents have been on the rise since 2017, and reached 12 in 2018. Companies have registered the most patents, followed by the Industry-University Cooperation Foundation. Zizyphi semen (n=6), Lactuca sativa L. (n=5), Valeriana fauriei/officinalis (n=4), Poria cocos (n=4) were frequently used herbs among 60 patents. Twenty-one patents (35%) included medicinal herbs with sleep improving effects. Among 60 patents, alcohol extraction (70%) was mostly used, followed by water immersion (50%), and hot water extraction (48.3%). Conclusions: Analysis results showed that various Korean medicine herbs, are being used for natural-products for sleep disorder. The results will be helpful towards inventing new patents using Korean medicine, developing natural product extracts for sleep improvement, and extending the range of these products in clinical use.

Keywords

Acknowledgement

This research was supported by the MSIT (Ministry of Science and ICT), Korea, under the Grand Information Technology Research Center support program (IITP-2022-2020-0-01791) supervised by the IITP (Institute for Information & communications Technology Planning & evaluation), and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HF22C0039).

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