Journal of Applied Biological Chemistry

  • 제65권3호
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  • Pages.183-187
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  • 2022
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  • 1976-0442(pISSN)
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  • 2234-7941(eISSN)
한국응용생명화학회 (The Korean Society for Applied Biological Chemistry)
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계피(Cinnamomum cassia Presl) 추출물과 cinnamaldehyde의 alcohol dehydrogenase 저해 효과

Inhibitory effect of cinnamon (Cinnamomum cassia Presl) extract and cinnamaldehyde on alcohol dehydrogenase

  • Do, Jaeho (Korea Ginseng MFG Co., Ltd) ;
  • In, Man-Jin (Department of Chemical Engineering, Chungwoon University) ;
  • Kim, Dong Chung (Department of Chemical Engineering, Chungwoon University)
  • 투고 : 2022.08.08
  • 심사 : 2022.08.22
  • 발행 : 2022.09.30
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초록

계피(Cinnamomum cassia Presl)의 열수 추출물은 alcohol dehydrogenase (ADH)의 활성을 저해하였고 IC50값은 45.6 ㎍/mL이었다. 계피 추출물의 ADH 저해 성분은 산과 열에 비교적 안정하였으나 휘발성을 가진 물질로 나타났다. 계피에서 ADH 저해 물질의 추출을 위한 최적 온도와 시간은 각각 80 ℃와 2시간이었다. 계피의 정유 성분 중 cinnamaldehyde가 ADH 저해의 주된 물질이었다. Cinnamaldehyde는 기질인 에탄올에 대해 ADH 활성의 경쟁적 저해제로 여겨진다. 따라서 계피 열수 추출물과 cinnamaldehyde는 ADH의 활성을 효과적으로 저해하는 숙취해소 천연소재로서의 활용가능성을 보여주었다.

The hot water extract from cinnamon (Cinnamomum cassia Presl) inhibited the activity of alcohol dehydrogenase (ADH) with IC50 value of 45.6 ㎍/mL. The ADH inhibitory components in cinnamon extract were relatively stable to acid and heat, but were found to be volatile. The optimum temperature and time for extracting the ADH inhibitory components from cinnamon were 80 ℃ and 2 h, respectively. Among the essential oils of cinnamon, cinnamaldehyde was the main substance for ADH inhibition. Cinnamaldehyde is considered a competitive inhibitor of ethanol to ADH. Therefore, the cinnamon extract and cinnamaldehyde showed the potential to be used as natural materials for relieving symptoms of a hangover.

키워드

과제정보

본 연구는 2022학년도 청운대학교 학술연구조성비 지원에 의해 수행된 것입니다.

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