Molecules and Cells

  • 제45권9호
  • /
  • Pages.610-619
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  • 2022
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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Transcriptional Heterogeneity of Cellular Senescence in Cancer

  • Junaid, Muhammad (Department of Biochemistry and Molecular Biology, Ajou University School of Medicine) ;
  • Lee, Aejin (Department of Biochemistry and Molecular Biology, Ajou University School of Medicine) ;
  • Kim, Jaehyung (Department of Biochemistry and Molecular Biology, Ajou University School of Medicine) ;
  • Park, Tae Jun (Department of Biochemistry and Molecular Biology, Ajou University School of Medicine) ;
  • Lim, Su Bin (Department of Biochemistry and Molecular Biology, Ajou University School of Medicine)
  • 투고 : 2022.03.06
  • 심사 : 2022.06.11
  • 발행 : 2022.09.30
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초록

Cellular senescence plays a paradoxical role in tumorigenesis through the expression of diverse senescence-associated (SA) secretory phenotypes (SASPs). The heterogeneity of SA gene expression in cancer cells not only promotes cancer stemness but also protects these cells from chemotherapy. Despite the potential correlation between cancer and SA biomarkers, many transcriptional changes across distinct cell populations remain largely unknown. During the past decade, single-cell RNA sequencing (scRNA-seq) technologies have emerged as powerful experimental and analytical tools to dissect such diverse senescence-derived transcriptional changes. Here, we review the recent sequencing efforts that successfully characterized scRNA-seq data obtained from diverse cancer cells and elucidated the role of senescent cells in tumor malignancy. We further highlight the functional implications of SA genes expressed specifically in cancer and stromal cell populations in the tumor microenvironment. Translational research leveraging scRNA-seq profiling of SA genes will facilitate the identification of novel expression patterns underlying cancer susceptibility, providing new therapeutic opportunities in the era of precision medicine.

키워드

과제정보

The scientific illustrations in Figures 1 and 2 are credited to W.H. Cho at the Medical Information & Media Center, Ajou University School of Medicine. This work is supported by the National Research Foundation (NRF) of Korea (2020R1A6A1A03043539, 2020M3A9D8037604, and 2022R1C1C1004756).

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