Molecules and Cells

  • 제45권9호
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  • Pages.603-609
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  • 2022
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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The Role of Extracellular Vesicles in Senescence

  • Oh, Chaehwan (Department of Biological Sciences, Chungnam National University) ;
  • Koh, Dahyeon (Department of Biological Sciences, Chungnam National University) ;
  • Jeon, Hyeong Bin (Department of Biological Sciences, Chungnam National University) ;
  • Kim, Kyoung Mi (Department of Biological Sciences, Chungnam National University)
  • 투고 : 2022.04.08
  • 심사 : 2022.06.18
  • 발행 : 2022.09.30
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초록

Cells can communicate in a variety of ways, such as by contacting each other or by secreting certain factors. Recently, extracellular vesicles (EVs) have been proposed to be mediators of cell communication. EVs are small vesicles with a lipid bilayer membrane that are secreted by cells and contain DNA, RNAs, lipids, and proteins. These EVs are secreted from various cell types and can migrate and be internalized by recipient cells that are the same or different than those that secrete them. EVs harboring various components are involved in regulating gene expression in recipient cells. These EVs may also play important roles in the senescence of cells and the accumulation of senescent cells in the body. Studies on the function of EVs in senescent cells and the mechanisms through which nonsenescent and senescent cells communicate through EVs are being actively conducted. Here, we summarize studies suggesting that EVs secreted from senescent cells can promote the senescence of other cells and that EVs secreted from nonsenescent cells can rejuvenate senescent cells. In addition, we discuss the functional components (proteins, RNAs, and other molecules) enclosed in EVs that enter recipient cells.

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과제정보

This work was supported by the research fund of Chungnam National University, and by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2020R1C1C1010869).

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