DOI QR코드

DOI QR Code

2020 Dietary Reference Intakes for Koreans: zinc

2020 한국인 영양소 섭취기준: 아연

  • Lee, Mi-Kyung (Department of Food and Nutrition, Sunchon National University) ;
  • Kim, Eun-Mee (Department of Dietetics, Samsung Medical Center) ;
  • Kwun, In-Sook (Department of Food and Nutrition, Andong National University)
  • Received : 2022.07.04
  • Accepted : 2022.08.17
  • Published : 2022.08.31

Abstract

This review is focused on analyzing the limits and shortage of zinc (Zn) for the 2020 Dietary Reference Intakes for Koreans (KDRIs), and provides suggestions for the future establishment of the 2025 KDRIs for Zn. The 2020 KDRIs for Zn have been established to estimate the adequate requirement (EAR), recommended nutrient intakes (RNI), adequate intake (for only 0-5 mon) and tolerable upper intake level (UL). EAR was estimated in 2-stages: the first stage was to construct of the frame of analysis for Zn requirement and the second stage involved a factorial approach by considering the various factors which affect Zn requirement, such as intestinal and urine Zn loss, Zn requirement for growth and development, and Zn absorption rate. For a more precise and accurate establishment of the Zn requirement, we suggest for the following to be considered: 1) considering that Zn is present in minuscule amounts as a trace element in our body, the present values for Zn EAR (as 6-9 mg/d) should be expressed as a decimal point for more accurate DRIs; 2) the frame of analysis for Zn requirement has to be more specifically and should includes the factors which affect Zn requirement; 3) both, the factorial approach and extrapolation method need to be well reviewed and thoroughly understood for establishing precise Zn requirement; 4) currently, human clinical study and balance study (Zn intake, excretion and absorption rate) are limited and more human Zn subject studies are required. All these suggestions are provided to better establish the Zn requirement in the 2025 KDRIs.

Keywords

Acknowledgement

This research was supported by Policy Research Program (project No. 20180415A1300, 25193068200, and 25203084501) from the Ministry of Health and Welfare in 2018-2020.

References

  1. Maret W. Zinc in cellular regulation: the nature and significance of "Zinc Signals". Int J Mol Sci 2017; 18(11): 2285-2296. https://doi.org/10.3390/ijms18112285
  2. Sandstrom B, Lonnerdal B. Promoters and antagonists of zinc absorption. In: Mills CF, editor. Zinc in Human Biology. New York (NY): Springer-Verlag; 1989. p. 57-78.
  3. Holt RR, Uriu-Adams JY, Keen CL. Zinc. Erdman JW Jr, MacDonald IA, Zeisel SH, editors. Present Knowledge in Nutrition, 10th ed. Washington, D.C.: International Life Science Institute-Nutrition Foundation; 2012. p.521-539.
  4. Nimmanon T, Ziliotto S, Ogle O, Burt A, Gee JM, Andrews GK, et al. The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis. Cell Mol Life Sci 2021; 78(4): 1781-1798. https://doi.org/10.1007/s00018-020-03616-6
  5. Hambidge KM. Mild zinc deficiency in human subjects. In: Mills CF, editor. Zinc in Human Biology. New York (NY): Springer-Verlag; 1989. p.281-296.
  6. Gupta S, Brazier AK, Lowe NM. Zinc deficiency in low- and middle-income countries: prevalence and approaches for mitigation. J Hum Nutr Diet 2020; 33(5): 624-643. https://doi.org/10.1111/jhn.12791
  7. The Korean Nutrition Society. 2015 Dietary Reference Intakes for Koreans. 4th rev. Seoul: The Korean Nutrition Society; 2015.
  8. The Korean Nutrition Society. 2020 Dietary Reference Intakes for Koreans: Minerals. 5th rev. Seoul: The Korean Nutrition Society; 2020.
  9. Korea Disease Control and Prevention Agency (KDCA). The report for Korean National Health and Nutrition Examination Survey (KNAHANES). Cheongju: KDCA; 2019.
  10. Fernandez-Cao JC, Warthon-Medina M, H Moran V, Arija V, Doepking C, Serra-Majem L, et al. Zinc intake and status and risk of type 2 diabetes mellitus: a systematic review and meta-analysis. Nutrients 2019; 11(5): 1027.
  11. Allen-Redpath K, Ou O, Beattie JH, Kwun IS, Feldmann J, Nixon GF. Marginal dietary zinc deficiency in vivo induces vascular smooth muscle cell apoptosis in large arteries. Cardiovasc Res 2013; 99(3): 525-534. https://doi.org/10.1093/cvr/cvt114
  12. Alcantara EH, Lomeda RA, Feldmann J, Nixon GF, Beattie JH, Kwun IS. Zinc deprivation inhibits extracellular matrix calcification through decreased synthesis of matrix proteins in osteoblasts. Mol Nutr Food Res 2011; 55(10): 1552-1560. https://doi.org/10.1002/mnfr.201000659
  13. Cole TB, Wenzel HJ, Kafer KE, Schwartzkroin PA, Palmiter RD. Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene. Proc Natl Acad Sci U S A 1999; 96(4): 1716-1721. https://doi.org/10.1073/pnas.96.4.1716
  14. Skalny AV, Rink L, Ajsuvakova OP, Aschner M, Gritsenko VA, Alekseenko SI, et al. Zinc and respiratory tract infections: Perspectives for COVID\xe2\x80\x9119 (review). Int J Mol Med 2020; 46(1): 17-26.
  15. Beattie JH, Malavolta M, Korichneva I. Zinc. In: Malavolta M, Mocchegiani E, editors. Trace Elements and Minerals in Health and Longevity. Cham: Springer; 2018. p.99-132.
  16. Giedroc DP, Keating KM, Martin CT, Williams KR, Coleman JE. Zinc metalloproteins involved in replication and transcription. J Inorg Biochem 1986; 28(2-3): 155-169. https://doi.org/10.1016/0162-0134(86)80079-4
  17. Gammoh NZ, Rink L. Zinc in infection and inflammation. Nutrients 2017; 9(6): 624.
  18. Kim YR, Kim YH. Therapeutic effects of zinc on patients who have sudden sensorineural hearing loss with normal serum zinc level. Korean J Otorhinolaryngol-Head Neck Surg 2015; 58(12): 831-835. https://doi.org/10.3342/kjorl-hns.2015.58.12.831
  19. The National Academy Press. Zn. In: Dietary Reference Intakes. Washing, D.C.: The National Academy Press; 2001. p.442-501.
  20. National Institute of Health. Zinc - Health Professional Fact Sheet (nih.gov) [Internet]. Bethesda (MD): National Institute of Health; 2021 [cited 2021 Sep 26]. Available from: https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/#h2.
  21. Kumanyika S, Oria MP. Guiding principles for developing dietary reference intakes based on chronic disease. Washington, D.C.: The National Academies Press; 2017. p.89-107.
  22. King JC, Brown KH, Gibson RS, Krebs NF, Lowe NM, Siekmann JH, et al. Biomarkers of nutrition for development (BOND)-zinc review. J Nutr 2015; 146(4): 858S-885S. https://doi.org/10.3945/jn.115.220079
  23. Gibson RS, King JC, Lowe N. A review of dietary zinc recommendations. Food Nutr Bull 2016; 37(4): 443-460. https://doi.org/10.1177/0379572116652252
  24. European Food Safety Authority (EFSA). Scientific opinion on dietary reference values for zinc. FESA Panel on Dietetic products, Nutrition and Allergies (NDA). EFSA J 2014; 12(10): 3844.
  25. European Food Safety Authority (EFSA). Dietary reference values for nutrients summary report. EFSA Support Publ 2017; 14(12): e15121E.
  26. Salmon J; Department of Health. Dietary reference values: a guide. London: HMSO; 1991. p.1-24.
  27. Lowe NM, Dykes FC, Skinner AL, Patel S, Warthon-Medina M, Decsi T, et al. EURRECA-Estimating zinc requirements for deriving dietary reference values. Crit Rev Food Sci Nutr 2013; 53(10): 1110-1123. https://doi.org/10.1080/10408398.2012.742863
  28. Bel-Serrat S, Stammers AL, Warthon-Medina M, Moran VH, Iglesia-Altaba I, Hermoso M, et al. Factors that affect zinc bioavailability and losses in adult and elderly populations. Nutr Rev 2014; 72(5): 334-352. https://doi.org/10.1111/nure.12105
  29. Statistics Korea. GDP per capita in South Koreans [Internet]. Daejeon: Statistics Korea; c2022 [cited 2022 Jul 4]. Available from: https://www.index.go.kr/unify/idx-info.do?idxCd=4221.
  30. National Institute of Agricultural Sciences. Korean food composition database 9.2 [Internet]. Wanju: National Institute of Agricultural Sciences; c2022 [cited 2020 Jul 7]. Available from: http://koreanfood.rda.go.kr/kfi/fct/fctIntro/list?menuId=PS03562#.
  31. Chung HY, Lee MK, Kim W, Choi MK, Kim SH, Kim E, et al. Issues pertaining to Mg, Zn and Cu in the 2020 dietary reference intakes for Koreans. Nutr Res Pract 2022; 16(Suppl 1): S113-S125. https://doi.org/10.4162/nrp.2022.16.S1.S113