Dementia and Neurocognitive Disorders (대한치매학회지)

Korean Dementia Association (대한치매학회)
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Association Between Body Mass Index and Cognitive Function in Mild Cognitive Impairment Regardless of APOE ε4 Status

  • Ye Sol Mun (Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine) ;
  • Hee Kyung Park (Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine) ;
  • Jihee Kim (Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine) ;
  • Jiyoung Yeom (Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine) ;
  • Geon Ha Kim (Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine) ;
  • Min Young Chun (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Hye Ah Lee (Clinical Trial Center, Mokdong Hospital, Ewha Womans University College of Medicine) ;
  • Soo Jin Yoon (Department of Neurology, Eulji University School of Medicine) ;
  • Kyung Won Park (Department of Neurology, Dong-A University College of Medicine) ;
  • Eun-Joo Kim (Department of Neurology, Pusan National University School of Medicine) ;
  • Bora Yoon (Department of Neurology, Konyang University Hospital, College of Medicine, Konyang University) ;
  • Jae-Won Jang (Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine) ;
  • Jin Yong Hong (Department of Neurology, Yonsei University Wonju College of Medicine) ;
  • Seong Hye Choi (Department of Neurology, Inha University Hospital, Inha University School of Medicine) ;
  • Jee Hyang Jeong (Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine)
  • Received : 2021.10.22
  • Accepted : 2021.12.01
  • Published : 2022.01.31
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Abstract

Background and Purpose: In this study we aimed to find the association between neuropsychological performance and body mass index (BMI) in patients with mild cognitive impairment (MCI). In addition, we investigated the effects of the apolipoprotein E (APOE) genotype in the relationship between the BMI and cognition in MCI. Methods: We enrolled a cohort of 3,038 subjects with MCI aged 65-90 from the Clinical Research Center for Dementia of South Korea and a dementia cohort of the Ewha Womans University Mokdong Hospital. MCI patients were classified into three subgroups according to the Asian standard of BMI. We compared cognitive performances between groups by one-way analysis of variance. To investigate the effects of the APOE genotype, we used multivariate linear regression models after adjusting for possible confounders. Results: Even though normal BMI groups were younger, had more females, and had less comorbidities, the higher BMI groups had better cognitive functions. Among subjects with APOE ε4 carriers, there was a positive relationship between the BMI and the memory task alone. Conclusions: Our findings suggested that higher BMI in patients with MCI were associated with better cognitive performance. The effects of the APOE ε4 genotype in the associations between BMI and cognition were distinguishing. Therefore, according to physical status, APOE ε4 genotype-specific strategies in the assessments and treatments may be necessary in elderly patients with MCI.

Keywords

Acknowledgement

This research was supported by the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2018M3C7A1057137 and NRF2020M3E5D2A01084721) and by the grants of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HU20C0271 and HU21C0016).

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