DOI QR코드

DOI QR Code

Successful use of a mesocaval shunt to treat refractory ascites in a chronic pancreatitis induced portal vein thrombosis

  • Souradeep Dutta (Division of Hepatopancreatobiliary Surgery, Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research) ;
  • Bishal Pal (Division of Hepatopancreatobiliary Surgery, Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research) ;
  • Duvuru Ram (Department of Cardiovascular and Thoracic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research) ;
  • Sreevathsa Kadaba Shyamprasad (Department of Cardiovascular and Thoracic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research) ;
  • Vishnu Prasad Nelamangala Ramakrishnaiah (Division of Hepatopancreatobiliary Surgery, Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research)
  • Received : 2021.10.19
  • Accepted : 2021.11.26
  • Published : 2022.05.31

Abstract

The state of intense peripancreatic inflammation in chronic pancreatitis can give rise to various vascular complications such as venous thrombosis and arterial pseudoaneurysms. Due to its intimate location with the pancreas, spleno-mesenteric-portal axis suffers the greatest blunt of thrombotic complications. Treatment modalities for such cases of chronic portal vein thrombosis have always been controversial and challenging. Medical management with anticoagulants is both risky and unsatisfactory due to presence of varices, hypersplenism, and persistence of the inflammatory pathology. Although endovascular techniques have been tried in various case reports, there are definite anatomical challenges in cases of long segment porto-mesenteric thrombosis with massive ascites. Surgical shunts have been historically described for cirrhotic and non-cirrhotic portal hypertensive patients. However, its use in patients with refractory ascites due to chronic pancreatitis induced portal vein thrombosis has not been reported in the medical literature. Here, we present a case of an extensive portal vein thrombosis with massive refractory ascites in a patient with alcohol-induced chronic pancreatitis successfully treated with a surgical mesocaval shunt using an interposition small diameter graft.

Keywords

References

  1. Etemad B, Whitcomb DC. Chronic pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology 2001;120:682-707.
  2. Anand A, Gunjan D, Agarwal S, Kaushal K, Sharma S, Gopi S, et al. Vascular complications of chronic pancreatitis: a tertiary center experience. Pancreatology 2020;20:1085-1091.
  3. Bernades P, Baetz A, Levy P, Belghiti J, Menu Y, Fekete F. Splenic and portal venous obstruction in chronic pancreatitis. A prospective longitudinal study of a medical-surgical series of 266 patients. Dig Dis Sci 1992;37:340-346.
  4. Chawla Y, Duseja A, Dhiman RK. Review article: the modern management of portal vein thrombosis. Aliment Pharmacol Ther 2009;30:881-894.
  5. Webster GJ, Burroughs AK, Riordan SM. Review article: portal vein thrombosis -- new insights into aetiology and management. Aliment Pharmacol Ther 2005;21:1-9.
  6. Stein M, Link DP. Symptomatic spleno-mesenteric-portal venous thrombosis: recanalization and reconstruction with endovascular stents. J Vasc Interv Radiol 1999;10:363-371.
  7. Plessier A, Darwish-Murad S, Hernandez-Guerra M, Consigny Y, Fabris F, Trebicka J, et al. Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study. Hepatology 2010;51:210-218.
  8. Loffredo L, Pastori D, Farcomeni A, Violi F. Effects of anticoagulants in patients with cirrhosis and portal vein thrombosis: a systematic review and meta-analysis. Gastroenterology 2017;153:480-487.e1.
  9. Orr DW, Harrison PM, Devlin J, Karani JB, Kane PA, Heaton ND, et al. Chronic mesenteric venous thrombosis: evaluation and determinants of survival during long-term follow-up. Clin Gastroenterol Hepatol 2007;5:80-86.
  10. Han G, Qi X, He C, Yin Z, Wang J, Xia J, et al. Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with symptomatic portal hypertension in liver cirrhosis. J Hepatol 2011;54:78-88.
  11. Moriarty JM, Kokabi N, Kee ST. Transvenous creation of a mesocaval shunt: report of use in the management of extrahepatic portal vein occlusion. J Vasc Interv Radiol 2012;23:565-567.
  12. Santy P, Marion P. [Technics of portacaval derivations]. Sem Hop 1953;29:2758-2767. French.
  13. Clatworthy HW, Wall T, Watman RN. A new type of portal-to-systemic venous shunt for portal hypertension. AMA Arch Surg 1955;71:588-599.
  14. Drapanas T. Interposition mesocaval shunt for treatment of portal hypertension. Ann Surg 1972;176:435-448.
  15. Cameron JL, Zuidema GD, Smith GW, Harrington DP, Maddrey WC. Mesocaval shunts for the control of bleeding esophageal varices. Surgery 1979;85:257-262.
  16. Mangla V, Pal S, Sahni P. Surgery for non-cirrhotic portal hypertension: current status. Trop Gastroenterol 2016;37:152-155.
  17. Bommana V, Shah P, Kometa M, Narwal R, Sharma P. A case of isolated duodenal varices secondary to chronic pancreatitis with review of literature. Gastroenterology Res 2010;3:281-286.
  18. Moore WS. Vascular and endovascular surgery e-book: a comprehensive review. 9th ed. Philadelphia: Elsevier, 2018.
  19. Drapanas T, LoCicero J 3rd, Dowling JB. Hemodynamics of the interposition mesocaval shunt. Ann Surg 1975;181:523-533.
  20. Mercado MA, Orozco H, Guillen-Navarro E, Acosta E, Lopez-Martinez LM, Hinojosa C, et al. Small-diameter mesocaval shunts: a 10-year evaluation. J Gastrointest Surg 2000;4:453-457.