대한임상독성학회지 (Journal of The Korean Society of Clinical Toxicology)

  • 제20권1호
  • /
  • Pages.8-14
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  • 2022
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  • 1738-1320(pISSN)
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  • 2508-6332(eISSN)
대한임상독성학회 (Korean society of Clincal Toxicology)
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진정수면제 음독 후 의식저하로 내원한 환자의 급성중독 비교

Comparative Analysis of decreased Mental state Patients after Overdose with Sedative-hypnotics

  • 오승재 (조선대학교 의과대학 응급의학교실) ;
  • 조수형 (조선대학교 의과대학 응급의학교실) ;
  • 류소연 (조선대학교 의과대학 예방의학교실)
  • Oh, Seung Jae (Department of Emergency Medicine, College of Medicine, Chosun University) ;
  • Cho, Soo Hyung (Department of Emergency Medicine, College of Medicine, Chosun University) ;
  • Ryu, So Yeon (Department of Preventive Medicine, College of Medicine, Chosun University)
  • 투고 : 2022.02.25
  • 심사 : 2022.06.23
  • 발행 : 2022.06.30
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초록

Purpose: This study was undertaken to investigate how sedative-hypnotics affect the occurrence and severity of the patient's symptoms. In addition, we conducted a study to determine the type of patients who reacted severely and required hospitalization; patients were accordingly classified as hospitalized patients and patients discharged from the emergency room. Methods: From January 2017 to December 2019, we investigated the demographics, drug information, history, laboratory tests, and severity of patients who visited our emergency department and were diagnosed with benzodiazepine, zolpidem, and doxylamine succinate overdose. We further compared details of hospitalized patients and discharged patients. Results: Subjects who had overdosed and visited the ED included 120 for benzodiazepine, 147 for zolpidem, and 27 for doxylamine succinate. Comparisons between the three groups revealed differences in their early diagnosis, psychiatric history, and sleep disturbance. Differences between groups were also determined for mental state, poisoning history, treatment received in the intensive care unit, and intubation and ventilator support. In cases of benzodiazepine overdose, we obtained a high hospitalization rate (40.0%), admission to the intensive care unit (24.2%), and intubation rate (18.3%). Comparisons between hospitalized patients and discharged groups showed differences in transferred patients, early diagnosis, and mental state. Conclusion: Patients poisoned by sedative-hypnotics are increasing every year. In cases of benzodiazepine and zolpidem, the hospitalization rates were high, and benzodiazepine overdose resulted in hospitalization, intensive care unit admission, and pneumonia in a majority of cases. Therefore, active treatment and quick decisions in the emergency room are greatly required.

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과제정보

이 논문은 2018년도 조선대학교병원 의료질향상 학술연구비의 지원을 받아 연구되었음.

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