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Therapeutic Effect of Autologous Activated Platelet-rich Plasma Therapy on Mid-dermal to Full-thickness Burns: A Case Series

  • Published : 2022.05.15

Abstract

Although modern medicine has made great strides in the management of burn injuries, associated complications such as pain, infection, dyspigmentation, and scarring have yet to be fully dealt with. Although skin grafting and meshing are routinely performed on burn patients, this method poses a risk for adverse effects. Activated autologous platelet-rich plasma (aaPRP), which is increasingly used in the field of plastic surgery, contains growth factors beneficial for wound regeneration. Seven cases of burns with varying severity and conditions that were treated with intralesional subcutaneous injection and intravenous aaPRP are presented and discussed herein. This case series indicates that subcutaneous and intravenous aaPRP is a safe procedure with the potential to be an alternative when skin grafting cannot be done or as an adjunct treatment to skin grafting.

Keywords

References

  1. Wang Y, Beekman J, Hew J, et al. Burn injury: challenges and advances in burn wound healing, infection, pain and scarring. Adv Drug Deliv Rev 2018;123:3-17 https://doi.org/10.1016/j.addr.2017.09.018
  2. Liu J, Qu W, Li R, Zheng C, Zhang L. Efficacy of autologous platelet-rich gel in the treatment of deep grade II burn wounds. Int J Clin Exp Med 2018;11(03):2654-2659
  3. Pavlovic V, Ciric M, Jovanovic V, Stojanovic P. Platelet rich plasma: a short overview of certain bioactive components. Open Med (Wars) 2016;11(01):242-247 https://doi.org/10.1515/med-2016-0048
  4. Wakayama T, Saita Y, Kobayashi Y, et al. Quality comparison between two different types of platelet-rich plasma for knee osteoarthritis. Regen Med Res 2020;8:3 https://doi.org/10.1051/rmr/200002
  5. Zhang W, Guo Y, Kuss M, et al. Platelet-rich plasma for the treatment of tissue infection: Preparation and clinical evaluation. Tissue Eng Part B Rev 2019;25(03):225-236 https://doi.org/10.1089/ten.teb.2018.0309
  6. Oryan A, Alidadi S, Moshiri A. Platelet-rich plasma for bone healing and regeneration. Expert Opin Biol Ther 2016;16(02):213-232 https://doi.org/10.1517/14712598.2016.1118458
  7. Karina K, Samudra MF, Rosadi I, et al. Combination of the stromal vascular fraction and platelet-rich plasma accelerates the wound healing process: pre-clinical study in a Sprague-Dawley rat model. Stem Cell Investig 2019;6(18):18 https://doi.org/10.21037/sci.2019.06.08
  8. Singer AJ, Boyce ST. Burn wound healing and tissue engineering. J Burn Care Res 2017;38(03):e605-e613 https://doi.org/10.1097/BCR.0000000000000538
  9. Vermeulen P, Dickens S, Degezelle K, Van den Berge S, Hendrickx B, Vranckx JJ. A plasma-based biomatrix mixed with endothelial progenitor cells and keratinocytes promotes matrix formation, angiogenesis, and reepithelialization in full-thickness wounds. Tissue Eng Part A 2009;15(07):1533-1542 https://doi.org/10.1089/ten.tea.2008.0246
  10. Morgan M, Deuis JR, Frosig-Jorgensen M, et al. Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment. Pain Med 2018;19(04):708-734 https://doi.org/10.1093/pm/pnx228
  11. Huang SH, Wu SH, Lee SS, et al. Platelet-rich plasma injection in burn scar areas alleviates neuropathic scar pain. Int J Med Sci 2018;15(03):238-247 https://doi.org/10.7150/ijms.22563
  12. Klifto KM, Dellon AL, Hultman CS. Prevalence and associated predictors for patients developing chronic neuropathic pain following burns. Burn Trauma 2020;8:tkaa011 https://doi.org/10.1093/burnst/tkaa011
  13. Soedjana H, Nadia J, Sundoro A, et al. The profile of severe burn injury patients with sepsis in hasan sadikin bandung general hospital. Ann Burns Fire Disasters 2020;33(04):312-316
  14. Chen J, Jain SA. Principles of skin grafts. In: Weinzweig J, ed. Plastic Surgery Secrets Plus. 2nd ed. Baltimore, MD: Mosby; 2010:677-683
  15. Aggarwal A, Chittoria RK, Dutta S, et al. Autologous platelet rich plasma: an adjunct to early tangential excision and grafting in burns. Plast Aesthetic Res 2018;5:47
  16. Alser OH, Goutos I. The evidence behind the use of platelet-rich plasma (PRP) in scar management: a literature review. Scars Burn Heal 2018;4:2059513118808773
  17. Nam SM, Kim YB. The effects of platelet-rich plasma on hypertrophic scars fibroblasts. Int Wound J 2018;15(04):547-554 https://doi.org/10.1111/iwj.12896
  18. Finnerty CC, Jeschke MG, Branski LK, Barret JP, Dziewulski P, Herndon DN. Hypertrophic scarring: the greatest unmet challenge after burn injury. Lancet 2016;388(10052):1427-1436 https://doi.org/10.1016/S0140-6736(16)31406-4
  19. Carter CA, Jolly DG, Worden CE Sr, Hendren DG, Kane CJM. Platelet-rich plasma gel promotes differentiation and regeneration during equine wound healing. Exp Mol Pathol 2003;74(03):244-255 https://doi.org/10.1016/S0014-4800(03)00017-0
  20. Rowan MP, Cancio LC, Elster EA, et al. Burn wound healing and treatment: review and advancements. Crit Care 2015;19:243 https://doi.org/10.1186/s13054-015-0961-2