The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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East Asian Herbal Medicine (EAHM) Alone for the Treatment of Women with Diminished Ovarian Reserve (DOR): A Systematic Review and Meta-analysis

난소예비력 저하 여성에 대한 한약 단독 치료의 임신 관련 지표 개선 효과에 관한 체계적 문헌 고찰 및 메타분석

  • Lee, Ju Hyun (Dept. of Pediatrics, College of Korean Medicine, Dong-Guk University) ;
  • Choi, Su-Ji (Dept. of Obstetrics & Gynecology, College of Korean Medicine, Dong-Guk University) ;
  • Noh, Eun-Ji (Dept. of Obstetrics & Gynecology, College of Korean Medicine, Dong-Guk University) ;
  • Min, Sang-Yeon (Dept. of Pediatrics, College of Korean Medicine, Dong-Guk University) ;
  • Kim, Dong-Il (Dept. of Obstetrics & Gynecology, College of Korean Medicine, Dong-Guk University)
  • 이주현 (동국대학교 한의과대학 소아과교실) ;
  • 최수지 (동국대학교 한의과대학 부인과교실) ;
  • 노은지 (동국대학교 한의과대학 부인과교실) ;
  • 민상연 (동국대학교 한의과대학 소아과교실) ;
  • 김동일 (동국대학교 한의과대학 부인과교실)
  • Received : 2022.01.07
  • Accepted : 2022.02.22
  • Published : 2022.03.01
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Abstract

Objectives: The aim of this study was to find out whether east asian herbal medicine (EAHM) treatment alone is effective in improving pregnancy-related indicators compared to conventional medicine in women with Diminished Ovarian Reserve (DOR). Methods: We searched eligible studies from PubMed, Cochrane Library, EMBASE, Chinese National Knowledge Infrastructure Database, CiNii, Korean Medical Database, Korean Studies Information Service System, Oriental Medicine Advanced Searching Integrated System, ScienceOn. GRADE pro was used to evaluate the current evidence of the study. Result: A total of 5 studies, 325 women with DOR were included. EAHM showed a significant effect on improvement of pregnancy rate (n=270, RR 2.13 [95% CI 1.44 to 3.15], Z=3.78, p=0.0002, I2=0%) and Anti-Mullerian Hormone (AMH) level (n=211, SMD 0.82 [95% CI 0.40 to 1.25], Z=3.80, p=0.0001) compared to conventional medicine. In ovulation rate (n=156, RR 0.86 [95% CI 0.70 to 1.06], Z=1.43, p=0.15, I2=0%), Antral Follicle Count (n=245, SMD 0.27 [95% CI -0.25 to 0.79], Z=1.01, p=0.31), and follicle stimulating hormone (n=245, SMD 0.29 [95% CI -0.13 to 0.70], Z=1.36, p=0.17) level, EAHM showed similar effects to conventional medicine. In this study, the most frequently used herbal medicines were Cuscutae Semen, Dipsaci Radix, and Angelicae Gigantis Radix. Conclusion: This meta-analysis showed that EAHM could improve pregnancy rates and AMH levels in women with DOR. However, more well-designed RCTs will have to be performed further in the future.

Keywords

Acknowledgement

이 연구는 보건복지부의 재원으로 한국보건산업진흥원의 한의약혁신기술개발사업 지원에 의하여 이루어진 것임 (HF21C0028).

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