Clinical and Experimental Reproductive Medicine

  • 제49권2호
  • /
  • Pages.101-109
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  • 2022
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  • 2233-8233(pISSN)
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  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
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Prevalence of Y chromosome microdeletions among infertile Mongolian men

  • 투고 : 2021.11.15
  • 심사 : 2022.01.06
  • 발행 : 2022.06.30
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초록

Objective: Y chromosome microdeletions are the second most common genetic cause of male infertility after Klinefelter syndrome. The aim of this study was to determine the patterns of Y chromosome microdeletions among infertile Mongolian men. Methods: A descriptive study was performed on 75 infertile men from February 2017 to December 2018. Y chromosome microdeletions were identified by polymerase chain reaction. Semen parameters, hormonal levels, and testis biopsy samples were examined. Results: Among 75 infertile men, two cases of Y chromosome microdeletions were identified. The first case had an AZFa complete deletion and the other had an AZFc partial deletion. This study found that the proportion of Y chromosome microdeletions among infertile Mongolian men was 2.66%. Conclusion: The findings can be applied to in vitro fertilization and assisted reproductive technology, and our results will help clinicians improve treatment management for infertile Mongolian couples.

키워드

과제정보

The authors would like to thank Dr. Sang-Jin Song for providing a Y chromosome microdeletion setting for this research. We would also like to thank Dr. Enkhee. O, the Head of the Department of Adult Pathology, National Center for Pathology of Mongolia for analyzing the biopsy results and Dr. Gantumur Battogtokh, R&D Center, Upex-Med Co. Ltd, South Korea, who helped with the writing and submission of the manuscript. The authors would also like to express their gratitude to all individuals who participated as patients in this study.

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