Acknowledgement
The authors would like to thank Dr. Sang-Jin Song for providing a Y chromosome microdeletion setting for this research. We would also like to thank Dr. Enkhee. O, the Head of the Department of Adult Pathology, National Center for Pathology of Mongolia for analyzing the biopsy results and Dr. Gantumur Battogtokh, R&D Center, Upex-Med Co. Ltd, South Korea, who helped with the writing and submission of the manuscript. The authors would also like to express their gratitude to all individuals who participated as patients in this study.
References
- Gnoth C, Godehardt E, Frank-Herrmann P, Friol K, Tigges J, Freundl G. Definition and prevalence of subfertility and infertility. Hum Reprod 2005;20:1144-7. https://doi.org/10.1093/humrep/deh870
- De Kretser DM, Baker HW. Infertility in men: recent advances and continuing controversies. J Clin Endocrinol Metab 1999;84:3443-50. https://doi.org/10.1210/jc.84.10.3443
- Purevtogtokh M, Batmunkh G. Determining the spread of infertility based on the data of the social indicators. Child Maternity Health Stud 2017;1:180-2.
- Bayasgalan G. The major clinical forms and risk factors of male infertility in Mongolia. Ulaanbaatar: Mongolian National University of Medical Sciences; 2005.
- Krausz C, Hoefsloot L, Simoni M, Tuttelmann F; European Academy of Andrology; European Molecular Genetics Quality Network. EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions: state-of-the-art 2013. Andrology 2014;2:5-19. https://doi.org/10.1111/j.2047-2927.2013.00173.x
- Repping S, Skaletsky H, Lange J, Silber S, Van Der Veen F, Oates RD, et al. Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure. Am J Hum Genet 2002;71:906-22. https://doi.org/10.1086/342928
- Vogt PH, Edelmann A, Kirsch S, Henegariu O, Hirschmann P, Kiesewetter F, et al. Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11. Hum Mol Genet 1996;5:933-43. https://doi.org/10.1093/hmg/5.7.933
- Vogt PH. Genomic heterogeneity and instability of the AZF locus on the human Y chromosome. Mol Cell Endocrinol 2004;224:1-9. https://doi.org/10.1016/j.mce.2004.06.008
- Tiepolo L, Zuffardi O. Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm. Hum Genet 1976;34:119-24. https://doi.org/10.1007/BF00278879
- Bor P, Hindkjaer J, Kolvraa S, Rossen P, von der Maase H, Jorgensen TM, et al. Screening for Y microdeletions in men with testicular cancer and undescended testis. J Assist Reprod Genet 2006;23: 41-5. https://doi.org/10.1007/s10815-005-9001-5
- Dewan S, Puscheck EE, Coulam CB, Wilcox AJ, Jeyendran RS. Y-chromosome microdeletions and recurrent pregnancy loss. Fertil Steril 2006;85:441-5. https://doi.org/10.1016/j.fertnstert.2005.08.035
- van der Ven K, Montag M, Peschka B, Leygraaf J, Schwanitz G, Haidl G, et al. Combined cytogenetic and Y chromosome microdeletion screening in males undergoing intracytoplasmic sperm injection. Mol Hum Reprod 1997;3:699-704. https://doi.org/10.1093/molehr/3.8.699
- Foresta C, Ferlin A, Garolla A, Moro E, Pistorello M, Barbaux S, et al. High frequency of well-defined Y-chromosome deletions in idiopathic Sertoli cell-only syndrome. Hum Reprod 1998;13:302-7. https://doi.org/10.1093/humrep/13.2.302
- Lin YM, Lin YH, Teng YN, Hsu CC, Shinn-Nan Lin J, Kuo PL. Gene-based screening for Y chromosome deletions in Taiwanese men presenting with spermatogenic failure. Fertil Steril 2002;77:897-903. https://doi.org/10.1016/S0015-0282(02)03059-5
- Athalye AS, Madon PF, Naik NJ, Naik DJ, Gavas SS, Dhumal SB, et al. A study of Y chromosome microdeletions in infertile Indian males. Int J Hum Genet 2004;4:179-85. https://doi.org/10.1080/09723757.2004.11885889
- Kumtepe Y, Beyazyurek C, Cinar C, Ozbey I, Ozkan S, Cetinkaya K, et al. A genetic survey of 1935 Turkish men with severe male factor infertility. Reprod Biomed Online 2009;18:465-74. https://doi.org/10.1016/S1472-6483(10)60121-6
- Saliminejad K, Sadeghi MR, Kamali K, Amirjannati N, Soltanghoraee H, Khorram Khorshid HR. Discrepancy in the frequency of Y chromosome microdeletions among Iranian infertile men with azoospermia and severe oligozoospermia. Genet Test Mol Biomarkers 2012;16:931-4. https://doi.org/10.1089/gtmb.2011.0378
- Akin H, Onay H, Turker E, Ozkinay F. Primary male infertility in Izmir/Turkey: a cytogenetic and molecular study of 187 infertile Turkish patients. J Assist Reprod Genet 2011;28:419-23. https://doi.org/10.1007/s10815-011-9542-8
- Zhang YS, Dai RL, Wang RX, Zhang HG, Chen S, Liu RZ. Analysis of Y chromosome microdeletion in 1738 infertile men from north-eastern China. Urology 2013;82:584-8. https://doi.org/10.1016/j.urology.2013.04.017
- Totonchi M, Mohseni Meybodi A, Borjian Boroujeni P, Sedighi Gilani M, Almadani N, Gourabi H. Clinical data for 185 infertile Iranian men with Y-chromosome microdeletion. J Assist Reprod Genet 2012;29:847-53. https://doi.org/10.1007/s10815-012-9798-7
- Kamp C, Huellen K, Fernandes S, Sousa M, Schlegel PN, Mielnik A, et al. High deletion frequency of the complete AZFa sequence in men with Sertoli-cell-only syndrome. Mol Hum Reprod 2001;7: 987-94. https://doi.org/10.1093/molehr/7.10.987
- Krausz C, Forti G. Clinical aspects of male infertility. Results Probl Cell Differ 2000;28:1-21. https://doi.org/10.1007/978-3-540-48461-5_1
- Wang LQ, Huang HF, Jin F, Qian YL, Cheng Q. High frequency of Y chromosome microdeletions in idiopathic azoospermic men with high follicle-stimulating hormone levels. Fertil Steril 2005;83: 1050-2. https://doi.org/10.1016/j.fertnstert.2004.09.029
- Kumar R, Dada R, Gupta NP, Kucheria K. Serum FSH levels and testicular histology in infertile men with non obstructive azoospermia and Y chromosome microdeletions. Indian J Urol 2006;22: 332-6. https://doi.org/10.4103/0970-1591.29119
- Tsai YR, Lan KC, Kung FT, Lin PY, Chiang HJ, Lin YJ, et al. The effect of advanced paternal age on the outcomes of assisted reproductive techniques among patients with azoospermia using cryopreserved testicular spermatozoa. Taiwan J Obstet Gynecol 2013;52: 351-5. https://doi.org/10.1016/j.tjog.2013.06.001
- Enatsu N, Miyake H, Chiba K, Fujisawa M. Predictive factors of successful sperm retrieval on microdissection testicular sperm extraction in Japanese men. Reprod Med Biol 2015;15:29-33. https://doi.org/10.1007/s12522-015-0212-x