Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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Effects of Herbal Medicines on Osteoporosis in Rheumatoid Arthritis: Study Protocol for a Systematic Review and Meta-Analysis

한약이 류마티스 관절염 환자의 골다공증에 미치는 영향: 체계적 문헌 고찰 및 메타분석을 위한 프로토콜

  • Kwon, Do Young (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Daejeon University) ;
  • Gu, Ji Hyang (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Daejeon University) ;
  • Lee, Eun Jung (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Daejeon University)
  • 권도영 (대전대학교 한의과대학 한방재활의학과교실) ;
  • 구지향 (대전대학교 한의과대학 한방재활의학과교실) ;
  • 이은정 (대전대학교 한의과대학 한방재활의학과교실)
  • Received : 2022.06.17
  • Accepted : 2022.07.04
  • Published : 2022.07.31
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Abstract

Objectives This study is designed to identify the effectiveness of herbal medicine for osteoporosis in rheumatoid arthritis. Methods We will investigate 10 databases, 4 Korean databases (KoreaMed, KMBASE, Koreanstudies Information Service System [KISS], ScienceOn) and 6 of abroad (PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure [CNKI], WanFang, Citation Information by NII [CiNii]) without publication date, language limitation for clinical study of herbal medicine for osteoporosis in rheumatoid arthritis. Type, dose, duration, frequency of herb medicine will be analyzed. Results Randomized controlled trials about herbal medicine or herb extract for osteoporosis in rheumatoid arthritis should be included in the study. Cochrane's risk of bias tools will be used to assess quality of the study. Mean differences or standardized mean differences of 95% confidence intervals will calculated and data synthesis will be conducted using Review Manager (RevMan, ver.5.3; The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark). Conclusions It is expected to provide basic data for the active use of herb medicine by systematically synthesizing and analyzing the actual situation, effectiveness, and safety of herb medicine for osteoporosis in rheumatoid arthritis.

Keywords

Acknowledgement

This study was supported by the Ministry of Education, Science and Technology (NRF-2021R1A2C2013483).

References

  1. Anonymous. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. The American Journal of Medicine. 1993;94:646-50. https://doi.org/10.1016/0002-9343(93)90218-E
  2. Chung HY. Osteoporosis diagnosis and treatment 2007. Journal of Korean Endocrine Society. 2008;23:76-108. https://doi.org/10.3803/jkes.2008.23.2.76
  3. Korean Society for Bone and Mineral Research. Osteoporosis. 5th ed. Seoul:Koonja Publishing. 2016:154-233.
  4. Korean College of Rheumatology. Rheumatology. 2nd ed. Seoul:Panmuneducation. 2018:184-233.
  5. Redlich K, Smolen JS. Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat Rev Drug Discov. 2012;11:234-50. https://doi.org/10.1038/nrd3669
  6. Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010;376:1094-108. https://doi.org/10.1016/S0140-6736(10)60826-4
  7. Haugeberg G, Uhlig T, Falch JA, Halse JI, Kvien TK. Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid. Arthritis Register Arthritis Rheum. 2000;43:522-30. https://doi.org/10.1002/1529-0131(200003)43:3<522::AID-ANR7>3.0.CO;2-Y
  8. Hauser B, Riches PL, Wilson JF, Horne AE, Ralston SH. Prevalence and clinical prediction of osteoporosis in a contemporary cohort of patients with rheumatoid arthritis. Rheumatology. 2014;53:1759-66. https://doi.org/10.1093/rheumatology/keu162
  9. Wu H, Cheng K, Guo Q, Yang W, Tong L, Wang Y, Sun Z. Mapping knowledge structure and themes trends of osteoporosis in rheumatoid arthritis: a bibliometric analysis. Front Med. 2021;8:787228. https://doi.org/10.3389/fmed.2021.787228
  10. Korean Society for Bone and Mineral Research. Physician's guide for osteoporosis. Seoul:Korean Society for Bone and Mineral Research Publishing. 2020:88.
  11. Cho SK, Sung YK. Treatment strategy for patients with rheumatoid arthritis. J Korean Med Assoc. 2020;63(7):422-30. https://doi.org/10.5124/jkma.2020.63.7.422
  12. Carbone LD, Kaeley G, McKown KM, Cremer M, Palmieri G, Kaplan S. Effects of long-term administration of methotrexate on bone mineral density in rheumatoid arthritis. Calcified Tissue International. 1999;64:100-1. https://doi.org/10.1007/s002239900585
  13. Mazzantini M, Di Munno O, Incerti-Vecchi L, Pasero G. Vertebral bone mineral density changes in female rheumatoid arthritis patients treated with low-dose methotrexate. Clinical and Experimental Rheumatology. 2000;18:327-31.
  14. Hong SM, Lee EJ. Effects of herbal medicines on bone mineral density score in osteoporosis or osteopenia: study protocol for a systematic review and meta-analysis. J Korean Med Rehabil. 2021;31(2):49-55. https://doi.org/10.18325/jkmr.2021.31.2.49
  15. Oh SJ, Ha HJ, Gu JH, Park YC, Oh MS, Jung IC, Lee EJ. The effect of herbal medicine on rheumatoid arthritis animal model: a systematic review of animal experiment studies published in Korea and overseas. J Korean Med Rehabil. 2020;30:103-16. https://doi.org/10.18325/jkmr.2020.30.3.103
  16. Yoo CK, Lee YJ. A case report of oligoarticular juvenile idiopathic arthritis with oriental medication and DMARDs & NSAIDs tapering. J Pediatr Korean Med. 2013;27(4):31-8. https://doi.org/10.7778/JPKM.2013.27.4.031
  17. An KS, Woo CH, Kwon OG, An HD. Therapeutic effects of Binsosan (檳蘇散) on adjuvant-induced rheumatoid rats. The Korean Journal of Oriental Medical Prescription. 2008;16(2):115-31.
  18. Ouyang GL, Feng XH, Xiao LB, Huang Z, Xia Q, Zhu F. Effects of Chinese herbal medicine Qianggu capsule on patients with rheumatoid arthritis-induced osteoporosis: a report of 82 cases. Zhong Xi Yi Jie He Xue Bao. 2012;10(12):1394-9.
  19. Jin YX, Wu P, Mao YF, Wang B, Zhang JF, Chen WL, Liu Z, Shi XL. Chinese herbal medicine for osteoporosis: a meta-analysis of randomized controlled trials. Journal of Clinical Densitometry: Assessment & Management of Musculoskeletal Health. 2017;20(4):516-25. https://doi.org/10.1016/j.jocd.2017.07.003
  20. Kim SY, Park JE, Seo HJ, Lee YJ, Jang BH, Son HJ, Suh HS, Shin CM. NECA's guidance for undertaking systematic reviews and meta-analysis for intervention. 1st ed. Seoul:National Evidence-based Healthcare Collaborating Agency. 2011:24-75.
  21. WHO Study Group. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organ Tech Rep Ser. 1994;843:1-129.
  22. Park JE, Oh DS, Choi JY, Jung SY, Kim AR, Koo CM, Jung HJ, Choi SM. Review of adverse events in acupuncture treatment. Korean Journal of Oriental Medicine. 2007;13(3):79-85.
  23. Kim HS, Dong KR, Ryu YH. Accurate quality control method of bone mineral density measurement -focus on dual energy X-ray absorptiometry-. Journal of Radiological Science and Technology. 2009;32(4):361-70.
  24. Ge J, Li SQ, Chen J, Xie LH, Xu HJ, Ma HZ. The effect of Xuling invigorating bone prescription on bone mineral density and the protein expression of OPG and RANKL in rat osteoporosis model. Chin J Osteoporos. 2016;22(5):592-5.
  25. The Society of Korean Medicine Rehabilitation. Korean medicine rehabilitation. 4th ed. Seoul:Koonja Publishing. 2015:35-134.
  26. Lim YW, Sun DH, Kim YS. Osteoporosis: pathogenesis and fracture prevention. Journal of the Korean Hip Society. 2009;21:6-16. https://doi.org/10.5371/jkhs.2009.21.1.6
  27. Fardellone P, Salawati E, Monnier LL, Goeb V. Bone loss, osteoporosis, and fractures in patients with rheumatoid arthritis: a review. J Clin Med. 2020;9(10):3361. https://doi.org/10.3390/jcm9103361
  28. Michaud K, Wolfe F. Comorbidities in rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2007;21:885-906. https://doi.org/10.1016/j.berh.2007.06.002
  29. Choi HJ. Treatment for osteoporosis: focusing on bisphosphonate therapy. Korean J Fam Pract. 2013;3:16-24.