The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지
DOI QR코드

DOI QR Code

A Case Report of Chemotherapy-Induced Peripheral Neuropathy Treated with Modified Guibi-tang

귀비탕가미방으로 호전된 항암화학요법 유발 말초신경병증 치험 1례

  • Park, Su Bin (Dept. of Korean Internal Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Yoon, Jee-Hyun (Dept. of Korean Internal Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Kim, Eun Hye (Dept. of Korean Internal Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Yoon, Seong Woo (Dept. of Korean Internal Medicine, Kyung Hee University Hospital at Gangdong)
  • 박수빈 (강동경희대학교한방병원 한방내과) ;
  • 윤지현 (강동경희대학교한방병원 한방내과) ;
  • 김은혜 (강동경희대학교한방병원 한방내과) ;
  • 윤성우 (강동경희대학교한방병원 한방내과)
  • Received : 2022.04.10
  • Accepted : 2022.07.06
  • Published : 2022.07.06
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: The purpose of this study was to report the effectiveness of modified Guibi-tang in a patient suffering from chemotherapy-induced peripheral neuropathy (CIPN). Methods: A 54-year-old Korean female patient diagnosed with recurrent ovarian cancer had CIPN with other symptoms, such as anorexia, dyspepsia, insomnia, etc. She was diagnosed with Simbiyangheo and hence treated with a modified Guibi-tang. Neuropathic symptoms were assessed using a numerical rating scale (NRS) and a sensory score. Quality of life was assessed using the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity (FACT/GOG-Ntx). Results: After 14 days of treatment, the patients showed a decrease in NRS for bilateral limb pain and improvement in other symptoms, such as general weakness, insomnia, dizziness, and headache. Quality of life also increased. Conclusion: Modified Guibi-tang may be considered an optional treatment for CIPN if the patient is diagnosed with Simbiyangheo. Further studies are needed to confirm this finding.

Keywords

Acknowledgement

본 연구는 보건복지부의 재원으로 한국보건 산업진흥원의 보건의료기술연구개발사업 지원에 의하여 이루어진 것임(HF20C0038).

References

  1. The Korea Central Cancer Registry, National Cancer Center. Annual report of cancer statistics in Korea in 2019. Ministry of Health and Welfare. 2021.
  2. Zajaczkowska R, Kocot-Kepska M, Leppert W, Wrzosek A, Mika J, Wordliczek J. Mechanisms of chemotherapy-induced peripheral neuropathy. International journal of molecular sciences 2019;20(6):1451. https://doi.org/10.3390/ijms20061451
  3. Windebank AJ, Grisold W. Chemotherapy-induced neuropathy. Journal of the Peripheral Nervous System 2008;13(1):27-46. https://doi.org/10.1111/j.1529-8027.2008.00156.x
  4. Park SB, Goldstein D, Krishnan AV, Lin CSY, Friendlander ML, Cassidy J, et al. Chemotherapy -induced peripheral neurotoxicity: a critical analysis. CA: a cancer journal for clinicians 2013;63(6):419-37. https://doi.org/10.3322/caac.21204
  5. Loprinzi CL, Lacchetti C, Bleeker J, Cavaletti G, Chauhan C, Hertz DL, et al. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: ASCO guideline update. J Clin Oncol 2020;38(28):3325-48. https://doi.org/10.1200/jco.20.01399
  6. Woo IS. Recent updates on chemotherapy-induced peripheral neuropathy. Korean Journal of Medicine 2015;88(1):35-7. https://doi.org/10.3904/kjm.2015.88.1.35
  7. Rostock M, Jaroslawski K, Guethlin C, Ludtke R, Schroder S, Bartsch HH. Chemotherapy-induced peripheral neuropathy in cancer patients: a four-arm randomized trial on the effectiveness of electroacupuncture. Evid Based Complement Alternat Med 2013;2013:349653.
  8. Yoon JH, Park SB, Lee JY, Kim EH, Yoon SW. A Case Report of Chemotherapy-Induced Peripheral Neuropathy Treated with Warm Needling. The Journal of Internal Korean Medicine 2021;42(2):114-21. https://doi.org/10.22246/jikm.2021.42.2.114
  9. Yoon J, Jeon JH, Lee YW, Cho CK, Kwon KR, Shin JE, et al. Sweet bee venom pharmacopuncture for chemotherapy-induced peripheral neuropathy. Journal of acupuncture and meridian studies 2012;5(4):156-65. https://doi.org/10.1016/j.jams.2012.05.003
  10. Park BR, Kim JM, Cho CK, Shin SH, Yoo HS. Effect of bee venom ointment treatment for chemotherapy-induced peripheral neuropathy: A case series. Journal of Haehwa Medicine 2014;22(2):111-7.
  11. Oh PJ, Kim YL. Effectiveness of non-pharmacologic interventions in chemotherapy induced peripheral neuropathy: a systematic review and meta-analysis. Journal of Korean Academy of Nursing 2018;48(2):123-42. https://doi.org/10.4040/jkan.2018.48.2.123
  12. Park JH, Jung IC, Lee SH, Lee JS, Bae KR, Cho CK, et al. Preliminary study to develop an instrument for pattern identification and evaluation for chemotherapy-induced peripheral neuropathy (CIPN). The Journal of Internal Korean Medicine 2016;37(1):77-89.
  13. Association of Korean Medicine Professors for Cardiovascular and Neurological Medicine, Cardiovascular and Neurological Medicine in Korean Medicine I. Seoul: Wooripub; 2018, p.289-308.
  14. Park JK, Kim DI. An Analysis of clinical application of Guibi-tang for obstetrics and gynecological disease. The Journal of Korean Obstetrics and Gynecology 2011;24(2):79-96. https://doi.org/10.15204/JKOBGY.2011.24.2.079
  15. Kim JH, Lee JK, Ha HK, Seo CS, Lee MY, Lee HY, et al. Analysis of Studies on Guibi-tang (Guipitang) for Fundamental Establishment of Evidence Based Medicine (EBM). Journal of Oriental Neuropsychiatry 2009;20(3):205-16.
  16. FACIT.org. FACT/GOG-NTX. Available from: https://www.facit.org/measures/FACT-GOG-NTX.
  17. Zhang S. Chemotherapy-induced peripheral neuropathy and rehabilitation: A review. Semin Oncol 2021;48(3):193-207. https://doi.org/10.1053/j.seminoncol.2021.09.004
  18. Yang TH, Oh MS. The recent essay of Bijeung-Study of III. Journal of Haehwa Medicine 2000;9(1):513-45.
  19. Noh H, Yoon SW, Park B. A Systematic Review of Herbal Medicine for Chemotherapy Induced Peripheral Neuropathy. Evid Based Complement Alternat Med 2018;2018:6194184.
  20. Park YG, Kim YK, Yun YG. A review on composition, action, compatibility of ingredients, clinicical application of Gwibitang. Herbal Formula Science 2007;15(2):1-8.
  21. Kook YB, Kim SC, Park SD, Park SK, Seo BI, Seo YB, et al. Text Book of the Herbal Formula Study. Seoul: Yunglimsa; 2016, p. 290-2.
  22. Kim EH, Yoon JH, Lee JY, Yoon SW. The therapeutic efficacy of acupuncture for chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. The Journal of Internal Korean Medicine 2020;41(3):350-61. https://doi.org/10.22246/jikm.2020.41.3.350
  23. Kim EH, Yoon SS, Lee JY, Yoon SW. A case of long-term survival with traditional Korean medicine alone for recurrent metastases of colorectal cancer. The Journal of Internal Korean Medicine 2019;40(4):723-9. https://doi.org/10.22246/jikm.2019.40.4.723
  24. Lee YJ, Lee JE, Kim SJ, Yoo JH. The study on effect of Korean medical treatment for patients with restless legs syndrome. Journal of Oriental Neuropsychiatry 2015;26(4):357-64. https://doi.org/10.7231/JON.2015.26.4.357
  25. Lee MH, Kim KM, Kim YK. A Case Report on the Effects of Gamiguibi-tang Combined with Sweet Bee Venom to Improve Raynaud's Disease. The Journal of Internal Korean Medicine 2017;38(5):698-708. https://doi.org/10.22246/jikm.2017.38.5.698
  26. NH X. Clinical study of Guizhi Guipi Decoction in the treatment of diabetes complicated with neuropathy. Journal of Aerospace Medicine 2014;25(7):1008-9.
  27. Yoshimura A, Sawada K, Sasano T, Kuroda H, Kozasa K, Nakatsuka E, et al. Effect of Japanese Kampo Medicine Therapy for Menopausal Symptoms after Treatment of Gynecological Malignancy. Obstetrics and Gynecology International 2018;2018:9475919. https://doi.org/10.1155/2018/9475919
  28. Perahia DG, Pritchett YL, Desaiah D, Raskin J. Efficacy of duloxetine in painful symptoms: an analgesic or antidepressant effect? International clinical psychopharmacology 2006;21(6):311-7. https://doi.org/10.1097/01.yic.0000224782.83287.3c
  29. The textbook compilation committee of neuropsychiatry of oriental schools in nation. The neuropsychiatry of oriental medicine. Seoul: Jipmoon-Dang; 2018, p. 80-3, 249-59, 391-402.