DOI QR코드

DOI QR Code

구강건조증에 대한 경피적전기신경자극(Transcutaneous electrical nerve stimulation)의 최근 임상연구 동향 고찰 - Pubmed와 국내 논문을 중심으로

A Review of Recent Clinical Studies of Transcutaneous Electrical Nerve Stimulation (TENS) on Xerostomia - PubMed and Domestic Studies

  • 이은경 (강동경희대학교 한방병원) ;
  • 전혜진 (강동경희대학교 한방병원 한방내과) ;
  • 김민정 (경희대학교 대학원 임상한의학과) ;
  • 박재우 (강동경희대학교 한방병원 한방내과) ;
  • 고석재 (강동경희대학교 한방병원 한방내과)
  • Lee, Eunkyung (Kyung Hee University Hospital at Gangdong) ;
  • Jun, Hyejin (Dept. of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Kim, Minjeong (Dept. of Clinical Korean Medicine, Graduate School of Kyung Hee University) ;
  • Park, Jae-Woo (Dept. of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Ko, Seok-Jae (Dept. of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong)
  • 투고 : 2022.05.24
  • 심사 : 2022.07.04
  • 발행 : 2022.06.30

초록

Objectives: The purpose of this study was to summarize current clinical study trends and results regarding transcutaneous electrical nerve stimulation (TENS) treatment for xerostomia. Methods: Studies published from 2017 to 2022 were searched on domestic databases and PubMed. The included studies were analyzed according to the year, language, study design, diagnosis xerostomia method, and TENS treatment method. Results: Nine studies were included. There were three randomized controlled trials (RCTs), three case series, one case report, one case-control study, and one cross-sectional study. Conventional TENS was used in seven studies, and acupuncture-like TENS (ALTENS) was used in one study. The most common TENS attachment site was externally on the skin overlying the parotid gland region, and the setting of TENS was 50 Hz-250 μs the most. In all nine studies, TENS was effective for xerostomia as assessed by salivary flow rate or quality of life questionnaire. Additionally, no persistent adverse events were reported after TENS treatment. Conclusions: TENS treatment for xerostomia can be considered effective and safe, so it can be used in clinical practice.

키워드

과제정보

본 연구는 경희대학교 산학협력단 설진기임상연구용역(20202584)의 지원에 의하여 이루어진 것임.

참고문헌

  1. Pedersen AM, Bardow A, Jensen SB, Nauntofte B. Saliva and Gastrointestinal Functions of Taste, Mastication, Swallowing and Digestion. Oral Dis 2002;8(3):117-29. https://doi.org/10.1034/j.1601-0825.2002.02851.x
  2. Dawes C. How Much Saliva Is Enough for Avoidance of Xerostomia? Caries Res 2004;38(3):236-40. https://doi.org/10.1159/000077760
  3. Villa A, Connell CL, Abati S. Diagnosis and Management of Xerostomia and Hyposalivation. Ther Clin Risk Manag 2014;11:45-51. https://doi.org/10.2147/TCRM.S76282
  4. Kwon HK, Lee JC, Lee BJ. Xerostomia. J Clin Otolaryngol 2020;31(1):11-7. https://doi.org/10.35420/JCOHNS.2020.31.1.11
  5. Guggenheimer J, Moore PA. Xerostomia: Etiology, Recognition and Treatment. J Am Dent Assoc 2003;134(1):61-9. https://doi.org/10.14219/jada.archive.2003.0018
  6. Park SW, Choi JW, Jeong MG, Lee KI, Kim HS. Comparison and Evaluation of Autonomic Nervous System (ANS) Activity According to the Stimulus Position of Transcutaneous Electrical Nerve Stimulation (TENS). J Biomed Eng Res 2021;42(3):107-15. https://doi.org/10.9718/JBER.2021.42.3.107
  7. Johnson MI. Transcutaneous Electrical Nerve Stimulation (TENS) and TENS-like Devices: Do They Provide Pain Relief? Pain Reviews 2001;8:121-58. https://doi.org/10.1191/0968130201pr182ra
  8. Ramesh C, Sawant S, Kolte D, Kumar B, Kranthi K, Patil T, et al. Efficacy of Transcutaneous Electrical Nerve Stimulation on Salivary Flow Rates in Normal Healthy Adults According to Gender and Age Groups. Asian J Neurosurg 2021;16(4):770-6. https://doi.org/10.4103/ajns.AJNS_48_21
  9. Aparna PV, Sankari SL, Deivanayagi M, Priyadharshini A, Vishnupriya CK, Niveditha B. Effect of Transcutaneous Electrical Nerve Stimulation on Parotid Saliva Flow in Patients with Hyposalivation. Asian J Pharm Clin Res 2017;9(Suppl1):S142-6.
  10. Dyasnoor S, Kamath S, Khader NFA. Effectiveness of Electrostimulation on Whole Salivary Flow Among Patients with Type 2 Diabetes Mellitus. Perm J 2017;21:15-164.
  11. Iovoli AJ, Singh AK. Accupuncture-like Transcutaneous Electrical Nerve Stimulation Therapy Success Using a Commercially Available Unit 8 Years Post-Radiation for Xerostomia: A Case Report. J Radiother Pr 2017;16(2):217-20. https://doi.org/10.1017/S1460396917000024
  12. Paim ED, Macagnan FE, Martins VB, Zanella VG, Guimaraes B, Berbert MCB. Transcutaneous Electrical Nerve Stimulation (TENS) on Hyposalivation Induced by Radiotherapy in the Head and Neck Region: A Preliminary Study. CoDAS 2018;30(3):e20170143.
  13. Yang LY, Chen HM, Su YC, Chin CC. The Effect of Transcutaneous Electrical Nerve Stimulation on Increasing Salivary Flow Rate in Hemodialysis Patients. Oral Dis 2019;25(1):133-41. https://doi.org/10.1111/odi.12948
  14. Dalbem Paim E, Costa Batista Berbert M, Gonzales Zanella V, Beatris Martins V, Edler Macagnan F. Effects of Transcutaneous Electrical Nerve Stimulation on the Salivary Flow of Patients with Hyposalivation Induced by Radiotherapy in the Head and Neck Region-A Randomised Clinical Trial. J Oral Rehabil 2019;46(12):1142-50. https://doi.org/10.1111/joor.12851
  15. Iovoli AJ, Ostrowski A, Rivers CI, Hermann GM, Groman A, Miller A, et al. Two- Versus Four-Times Weekly Acupuncture-Like Transcutaneous Electrical Nerve Stimulation for Treatment of Radiation-Induced Xerostomia: A Pilot Study. J Altern Complement Med 2020;26(4):323-8. https://doi.org/10.1089/acm.2019.0131
  16. Chandra R, Bhakta P, Beniwal J, Dhanda R, Saxena V, Sinha S. Evaluation of the Efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) on Salivary Flow Rate in Patients with Xerostomia - A Case Control Study. J Fam Med Prim Care 2022;11(2):767-71. https://doi.org/10.4103/jfmpc.jfmpc_922_21
  17. Baharvand M, Khodadoustan A, Mohammadi M, Mortazavi H, Movahhedian A. Xerostomia Due to Systemic Disease: A Review of 20 Conditions and Mechanisms. Ann Med Health Sci Res 2014;4(4):503-10. https://doi.org/10.4103/2141-9248.139284
  18. Wong RKW, James JL, Sagar S, Wyatt G, Nguyen-Tan PF, Singh AK, et al. Phase 2 Results from Radiation Therapy Oncology Group Study 0537. Cancer 2012;118(17):4244-52. https://doi.org/10.1002/cncr.27382
  19. Aggarwal H, Pal-Singh M, Mathur H, Astekar S, Gulati P, Lakhani S. Evaluation of the Effect of Transcutaneous Electrical Nerve Stimulation (TENS) on Whole Salivary Flow Rate. J Clin Exp Dent 2015;7(1):e13-7.
  20. Mercadante V, Al Hamad A, Lodi G, Porter S, Fedele S. Interventions for the Management of Radiotherapy-Induced Xerostomia and Hyposalivation: A Systematic Review and Meta-Analysis. Oral Oncol 2017;66:64-74. https://doi.org/10.1016/j.oraloncology.2016.12.031
  21. Ma SJ, Rivers CI, Serra LM, Singh AK. Long-Term Outcomes of Interventions for Radiation-Induced Xerostomia: A Review. World J Clin Oncol 2019;10(1):1-13. https://doi.org/10.5306/wjco.v10.i1.1
  22. Salimi F, Saavedra F, Andrews B, FitzGerald J, Winter SC. Trans-Cutaneous Electrical Nerve Stimulation to Treat Dry Mouth (Xerostomia) Following Radiotherapy for Head and Neck Cancer. A Systematic Review. Ann Med Surg 2021;63:102146. https://doi.org/10.1016/j.amsu.2021.01.094
  23. Paim ED, Berbert MCB, Zanella VG, Macagnan FE. Electrical Stimulation in the Treatment of Radiotherapy-Induced Hyposalivation. Codas 2019;31(4):1-7.
  24. Sivaramakrishnan G, Sridharan K. Electrical Nerve Stimulation for Xerostomia: A Meta-Analysis of Randomised Controlled Trials. J Tradit Complement Med 2017;7(4):409-13. https://doi.org/10.1016/j.jtcme.2017.01.004