Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
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Saudi Experts Consensus on Diagnosis and Management of Pediatric Functional Constipation

  • Alshehri, Dhafer B. (Department of Pediatrics, Faculty of Medicine, Najran University) ;
  • Sindi, Haifa Hasan (Royal Commission Medical Center) ;
  • AlMusalami, Ibrahim Mohamod (Pediatric Department, Maternity and Children's Hospital) ;
  • Rozi, Ibrahim Hosamuddin (Department of Pediatrics, King Fahd Armed Forces Hospital) ;
  • Shagrani, Mohamed (King Faisal Specialist Hospital and Research Centre, Pediatric Gastroenterology) ;
  • Kamal, Naglaa M. (Pediatric Department, Kasr Alainy Faculty of Medicine, Cairo University) ;
  • Alahmadi, Najat Saeid (Pediatric Department, King Salman Medical City, Ministry of Health) ;
  • Alfuraikh, Samia Saud (King Abdul Aziz Hospital, Ministry of National Guard Health Affairs) ;
  • Vandenplas, Yvan (Vrije Universiteit Brussel, UZ Brussel, KidZ Health Castle)
  • Received : 2021.09.16
  • Accepted : 2022.03.07
  • Published : 2022.05.15
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Abstract

Although functional gastrointestinal disorders (FGIDs) are very common in pediatric patients, there is a scarcity of published epidemiologic data, characteristics, and management patterns from Saudi Arabia, which is the 2nd largest Arabic country in terms of area and the 6th largest Arabic country in terms of population, with 10% of its population aged <5 years. Functional constipation (FC) is an FGID that has shown a rising prevalence among Saudi infants and children in the last few years, which urges us to update our clinical practices. Nine pediatric consultants attended two advisory board meetings to discuss and address current challenges, provide solutions, and reach a Saudi national consensus for the management of pediatric constipation. The pediatric consultants agreed that pediatricians should pay attention to any alarming signs (red flags) found during history taking or physical examinations. They also agreed that the Rome IV criteria are the gold standard for the diagnosis of pediatric FC. Different therapeutic options are available for pediatric patients with FC. Dietary treatment is recommended for infants with constipation for up to six months of age. When non-pharmacological interventions fail to improve FC symptoms, pharmacological treatment with laxatives is indicated. First, the treatment is aimed at disimpaction to remove fecal masses. This is achieved by administering a high dose of oral polyethylene glycol (PEG) or lactulose for a few days. Subsequently, maintenance therapy with PEG should be initiated to prevent the re-accumulation of feces. In addition to PEG, several other options may be used, such as Mg-rich formulas or stimulant laxatives. However, rectal enemas and suppositories are usually reserved for cases that require acute pain relief. In contrast, infant formulas that contain prebiotics or probiotics have not been shown to be effective in infant constipation, while the use of partially hydrolyzed formula is inconclusive. These clinical practice recommendations are intended to be adopted by pediatricians and primary care physicians across Saudi Arabia.

Keywords

Acknowledgement

The consensus panel experts would like to thank Novalac Middle East for their organization and support of the Working Group, which facilitated the process of consensus manuscript development. We would also like to thank Dr. Ahmed Salah Hussein M.D of RAY-CRO for his editorial support in drafting and writing consensus statements.

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