대한의생명과학회지 (Biomedical Science Letters)

  • 제28권2호
  • /
  • Pages.92-100
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  • 2022
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
권호 표지
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Ginkgo biloba Leaf Extract Regulates Cell Proliferation and Gastric Cancer Cell Death

  • Kim, Da Hyun (Department of Biomedical Laboratory Science, Daegu Haany University) ;
  • Yang, Eun Ju (Department of Biomedical Laboratory Science, Daegu Haany University) ;
  • Lee, JinAh (Zoonotic Virus Laboratory, Institut Pasteur Korea) ;
  • Chang, Jeong Hyun (Department of Biomedical Laboratory Science, Daegu Haany University)
  • 투고 : 2022.06.14
  • 심사 : 2022.06.27
  • 발행 : 2022.06.30
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초록

Ginkgo biloba Leaf Extract (GBE) is an extract from leaves of the Ginkgo biloba tree, widely used as a health supplement. GBE can inhibit the proliferation of several types of tumor cell. Although it is known to have anti-cancer effects in breast cancer and skin cancer, research related to gastric cancer is still insufficient. Based on results showing anti-cancer effects on solid cancer, we aimed to determine whether GBE has similar effects on gastric cancer. In this study, the anti-cancer effect of GBE in gastric adenocarcinoma was investigated by confirming the cell proliferation inhibitory effect of AGS cells. We also evaluated whether GBE regulates expression of the tumor suppressor protein p53 and Rb. GBE has apoptotic effects on AGS cells that were confirmed by changes in anti-apoptosis protein Bcl-2, Bcl-xl and pro-apoptosis protein Bax levels. Wound healing and cell migration were also decreased by treatment with GBE. Furthermore, we verified the effects of GBE on mitogenic signaling by investigating AKT target gene expression levels and revealed downregulated Sod2 and Bcl6 expression. We also confirmed that expression of inflammation-related genes decreased in a time-dependent manner. These results indicate that GBE has an anti-cancer effect on human gastric cancer cell lines. Further research on the mechanism of the anti-cancer effect will serve as basic data for possible anti-cancer drug development.

키워드

과제정보

This research was supported by a grant from Daegu Haany University Ky-lin Foundation in 2021.

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