Journal of Ginseng Research

  • 제46권4호
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  • Pages.609-619
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  • 2022
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
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Regulation of appetite-related neuropeptides by Panax ginseng: A novel approach for obesity treatment

  • Phung, Hung Manh (Department of Preventive Medicine, College of Korean Medicine, Gachon University) ;
  • Jang, Dongyeop (Department of Physiology, College of Korean Medicine, Gachon University) ;
  • Trinh, Tuy An (Department of Preventive Medicine, College of Korean Medicine, Gachon University) ;
  • Lee, Donghun (Department of Herbal Pharmacology, College of Korean Medicine, Gachon University) ;
  • Nguyen, Quynh Nhu (Department of Preventive Medicine, College of Korean Medicine, Gachon University) ;
  • Kim, Chang-Eop (Department of Physiology, College of Korean Medicine, Gachon University) ;
  • Kang, Ki Sung (Department of Preventive Medicine, College of Korean Medicine, Gachon University)
  • 투고 : 2021.10.11
  • 심사 : 2022.03.29
  • 발행 : 2022.07.01
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초록

Obesity is a primary factor provoking various chronic disorders, including cardiovascular disease, diabetes, and cancer, and causes the death of 2.8 million individuals each year. Diet, physical activity, medications, and surgery are the main therapies for overweightness and obesity. During weight loss therapy, a decrease in energy stores activates appetite signaling pathways under the regulation of neuropeptides, including anorexigenic [corticotropin-releasing hormone, proopiomelanocortin (POMC), cholecystokinin (CCK), and cocaine- and amphetamine-regulated transcript] and orexigenic [agoutirelated protein (AgRP), neuropeptide Y (NPY), and melanin-concentrating hormone] neuropeptides, which increase food intake and lead to failure in attaining weight loss goals. Ginseng and ginsenosides reverse these signaling pathways by suppressing orexigenic neuropeptides (NPY and AgRP) and provoking anorexigenic neuropeptides (CCK and POMC), which prevent the increase in food intake. Moreover, the results of network pharmacology analysis have revealed that constituents of ginseng radix, including campesterol, beta-elemene, ginsenoside Rb1, biotin, and pantothenic acid, are highly correlated with neuropeptide genes that regulate energy balance and food intake, including ADIPOQ, NAMPT, UBL5, NUCB2, LEP, CCK, GAST, IGF1, RLN1, PENK, PDYN, and POMC. Based on previous studies and network pharmacology analysis data, ginseng and its compounds may be a potent source for obesity treatment by regulating neuropeptides associated with appetite.

키워드

과제정보

This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) of Korea funded by Ministry of Science & ICT (2020M3A9E4104380).

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