Acknowledgement
This research was supported by the 2021 scientific promotion program funded by Jeju National University.
References
- Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68(1): 7-30. doi: 10.3322/caac.21442
- Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM (2014) Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res 74(11): 2913-2921. doi: 10.1158/0008-5472.CAN-14-0155
- Chand S, O'Hayer K, Blanco FF, Winter JM, Brody JR (2016) The Landscape of Pancreatic Cancer Therapeutic Resistance Mechanisms. Int J Biol Sci 12(3): 273-282. doi: 10.7150/ijbs.14951
- Bullock A, Stuart K, Jacobus S, Abrams T, Wadlow R, Goldstein M, Miksad R (2017) Capecitabine and oxaliplatin as first and second line treatment for locally advanced and metastatic pancreatic ductal adenocarcinoma. J Gastrointest Oncol 8(6): 945-952. doi: 10.21037/jgo.2017.06.06
- Ono H, Basson MD, Ito H (2014) PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling. PLoS One 9(5): e96060. doi: 10.1371/journal.pone.0096060
- Balunas MJ, Kinghorn AD (2005) Drug discovery from medicinal plants. Life Sci 78(5): 431-441. doi: 10.1016/j.lfs.2005.09.012
- Thomford NE, Senthebane DA, Rowe A, Munro D, Seele P, Maroyi A, Dzobo K (2018) Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery. Int J Mol Sci 19(6):1578. doi: 10.3390/ijms19061578
- Millimouno FM, Dong J, Yang L, Li J, Li X (2014) Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature. Cancer Prev Res (Phila) 7(11): 1081-1107. doi: 10.1158/1940-6207.CAPR-14-0136
- Fabricant DS, Farnsworth NR (2001) The value of plants used in traditional medicine for drug discovery. Environ Health Perspect 109(1):69-75. doi: 10.1289/ehp.01109s169
- Zamora-Ros R, Touillaud M, Rothwell JA, Romieu I, Scalbert A (2014) Measuring exposure to the polyphenol metabolome in observational epidemiologic studies: current tools and applications and their limits. Am J Clin Nutr 100(1): 11-26. doi: 10.3945/ajcn.113.077743
- Tripoli E, Guardia ML, Giammanco S, Majo DD, Giammanco M (2007) Citrus flavonoids: Molecular structure, biological activity and nutritional properties: A review. Food Chemistry 104(2): 466-479. doi: 10.1016/j.foodchem.2006.11.054
- Xu D, Hu MJ, Wang YQ, Cui YL (2019) Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Molecules 24(6): 1123. doi: 10.3390/molecules24061123
- He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z (2015) Curcumin, inflammation, and chronic diseases: how are they linked? Molecules 20(5): 9183-9213. doi: 10.3390/molecules20059183
- Alkhalidy H, Moore W, Wang Y, Luo J, McMillan RP, Zhen W, Zhou K, Liu D (2018) The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production. Molecules 23(9): 2238. doi: 10.3390/molecules23092338
- Lee J, Han SI, Yun JH, Kim JH (2015) Quercetin-3-O-glucoside supress epidermal growth factor-induced migaration by inhibiting EGFR signaling in pancreatic cancer cells. Tumour Biol 36(12): 9385-9393. doi: 10.1007/s13277-015-3682-x
- Sak K (2012) Chemotherapy and dietary phytochemical agents. Chemother Res Pract 2012: 282570, PMID: 23320169. doi: 10.1155/2012/282570
- Maru GB, Hudlikar RR, Kumar G, Gandhi K, Mahimkar MB (2016) Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals: From experimental models to clinical trials. World J Biol Chem 7(1): 88-99. doi: 10.4331/wjbc.v7.i1.88
- Ravishankar D, Rajora AK, Greco F, Osborn HM (2013) Flavonoids as prospective compounds for anti-cancer therapy. Int J Biochem Cell Biol 45(12): 2821-2831. doi: 10.1016/j.biocel.2013.10.004
- Miyake Y, Yamamoto K, Osawa T (1997) Isolation of Eriocitrin (Eriodictyol 7-rutinoside) from Lemon Fruit (Citrus limon BURM. f.) and Its Antioxidative Activity. Food Science and Technology International, Tokyo 3(1): 84-89. doi: 10.3136/fsti9596t9798.3.84
- Brito A, Ramirez JE, Areche C, Sepulveda B, Simirgiotis MJ (2014) HPLC-UV-MS profiles of phenolic compounds and antioxidant activity of fruits from three citrus species consumed in Northern Chile. Molecules 19(11): 17400-1742. doi: 10.3390/molecules191117400
- Mandalari G, Bennett RN, Bisignano G, Saija A, Dugo G, Lo Curto RB, Waldron KW (2006) Characterization of flavonoids and pectins from bergamot (Citrus bergamia Risso) peel, a major byproduct of essential oil extraction. J Agric Food Chem 54(1): 197-203. doi: 10.1021/jf051847n
- Mariyappan P, Kalaiyarasu T, Manju V (2017) Effect of eriodictyol on preneoplastic lesions, oxidative stress and bacterial enzymes in 1,2-dimethyl hydrazine-induced colon carcinogenesis. Toxicol Res (Camb) 6(5): 678-692. doi: 10.1039/c7tx00074j
- Wang F, Wang Y-H, Wang J-J, Xu H-L, Wang C-M (2016) Eriodictyol-induced anti-cancer and apoptotic effects in human hepatocellular carcinoma cells are associated with cell cycle arrest and modulation of apoptosis-related proteins. Bangladesh Journal of Pharmacology 11(2):285. doi: 10.3329/bjp.v11i2.25549
- Zhang Y, Zhang R, Ni H (2020) Eriodictyol exerts potent anticancer activity against A549 human lung cancer cell line by inducing mitochondrial-mediated apoptosis, G2/M cell cycle arrest and inhibition of m-TOR/PI3K/Akt signalling pathway. Arch Med Sci 16(2): 446-452. doi: 10.5114/aoms.2019.85152
- Kim DH, Han SI, Go B, Oh UH, Kim CS, Jung YH, Lee J, Kim JH (2019) 2-Methoxy-4-vinylphenol Attenuates Migration of Human Pancreatic Cancer Cells via Blockade of FAK and AKT Signaling. Anticancer Res 39(12): 6685-6691. doi: 10.21873/anticanres.13883
- Huang M, Tang SN, Upadhyay G, Marsh JL, Jackman CP, Shankar S, Srivastava RK (2014) Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways. PLoS One 9(4):e92161. doi: 10.1371/journal.pone.0092161
- Zhang Y, Zhang XX, Yuan RY, Ren T, Shao ZY, Wang HF, Cai WL, Chen LT, Wang XA, Wang P (2018) Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo. Onco Targets Ther 11:4479-4490. doi: 10.2147/OTT.S164670
- Zhang L, Fang Y, Xu XF, Jin DY (2017) Moscatilin induces apoptosis of pancreatic cancer cells via reactive oxygen species and the JNK/SAPK pathway. Mol Med Rep 15: 1195-1203. doi: 10.3892/mmr.2017.6144
- Awasthi N, Monahan S, Stefaniak A, Schwarz MA, Schwarz RE (2018) Inhibition of the MEK/ERK pathway augments nab-paclitaxel-based chemotherapy effects in preclinical models of pancreatic cancer. Oncotarget 9: 5274-5286. doi: 10.18632/oncotarget.23684
- Lane D, Matte I, Laplante C, Garde-Granger P, Rancourt C, Piche A (2013) Osteoprotegerin (OPG) activates integrin, focal adhesion kinase (FAK), and Akt signaling in ovarian cancer cells to attenuate TRAIL-induced apoptosis. J Ovarian Res 6(1): 82. doi: 10.1186/1757-2215-6-82
- Koff JL, Ramachandiran S, Bernal-Mizrachi L (2015) A time to kill: targeting apoptosis in cancer. Int J Mol Sci 16(2): 2942-2955. doi: 10.3390/ijms16022942
- Lee J, Hun Yun J, Lee J, Choi C, Kim JH (2015) Blockade of dualspecificity phosphatase 28 decreases chemo-resistance and migration in human pancreatic cancer cells. Sci Rep 5: 12296. doi: 10.1038/srep12296
- Kanteti R, Batra SK, Lennon FE, Salgia R (2016) FAK and paxillin, two potential targets in pancreatic cancer. Oncotarget 24, 31586-31601. doi: 10.18632/oncotarget.8040
- Chan PC, Lai JF, Cheng CH, Tang MJ, Chiu CC, Chen HC (1999) Suppression of ultraviolet irradiation-induced apoptosis by overexpression of focal adhesion kinase in Madin-Darby canine kidney cells. J Biol Chem 274(38): 26901-26906. doi: 10.1074/jbc.274.38.26901
- Kim A, Im M, Yim NH, Kim T, Ma JY (2014) A novel herbal medicine, KIOM-C, induces autophagic and apoptotic cell death mediated by activation of JNK and reactive oxygen species in HT1080 human fibrosarcoma cells. PLoS One 9(5): e98703. doi: 10.1371/journal.pone.0098703
- Zhang X, Jiang J, Chen Z, Cao M (2019) Silibinin inhibited autophagy and mitochondrial apoptosis in pancreatic carcinoma by activating JNK/SAPK signaling. Pathol Res Pract 215(9): 152530. doi: 10.1016/j.prp.2019.152530
- Li J, Liang X, Yang X (2012) Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-kB pathways. Oncol Rep 28: 501-510. doi: 10.3892/or.2012.1827
- Li W, Du Q, Li X, Zhang X, Lv F, Huang G, Yang J, Liu S (2020) Eriodictyol inhibits proliferation, metastasis and induces apoptosis of glioma cells via PI3K/AKT/ NF-kB signaling pathway. Front Pharmacol 25(11): 114. doi: 10.3389/fphar.2020.00114