Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Chemical Profile and Cytotoxicity Activity of Stem-bark of Anacardium occidentale

  • Shehu, Abdullahi (Department of Chemistry, Faculty of Science, Federal University Lokoja) ;
  • Ponnapalli, Mangala Gowri (Centre for Natural Products and Traditional Knowledge, Indian Institute of Chemical Technology) ;
  • Mahboob, Mohd (Toxicology Unit, Biology Division, Indian Institute of Chemical Technology) ;
  • Prabhakar, Pitta Venkata (Toxicology Unit, Biology Division, Indian Institute of Chemical Technology) ;
  • Olatunji, Gabriel Ademola (Department of Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin)
  • Received : 2022.05.23
  • Accepted : 2022.06.15
  • Published : 2022.06.30
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Abstract

Column chromatographic fractionation of the methanol and ethyl acetate extracts of the stem-bark of Anacardium occidentale led to the isolation of five compounds (1-5). Their structures were determined by spectroscopic means by comparing spectral data to be β-sitosterol (1), 2,4-dihydroxy acetophenone (2), 1-monolinolein (3), ethyl oleate (4) and β-sitosterol-3-O-β-D-glucopyranoside (5). These compounds were evaluated for cytotoxicity against human cancer cell lines: A549, SCOV3 and rat normal cell line NRK49f. Compounds 2-5 were for the first time isolated from A. occidentale.

Keywords

Acknowledgement

The authors acknowledge Tertiary Education Fund (TETFUND), Federal University Lokoja, Nigeria; The World Academic of Science (TWAS), Italy and the council for Scientific and Industrial Research (CSIR)/Indian Institute of Chemical Technology (IICT), India for constant support and encouragement.

References

  1. Trease, G. E.; Evans, W. C. Pharmacology. 1st ed; Bailliere Tindal: UK, 1978, p 113-114
  2. Iwu, M. M. Handbook of African Medicinal Plants. 2nd; CRC press: USA, 2014, p 137.
  3. Cano, J. H.; Volpato, G. J. Ethnopharmcol. 2004, 90, 293-316. https://doi.org/10.1016/j.jep.2003.10.012
  4. Mota, M. L.; Thomas, G.; Barbosa Filho, J. M. J. Ethnopharmacol. 1985, 13, 289-300. https://doi.org/10.1016/0378-8741(85)90074-1
  5. Kudi, A. C.; Umoh, J. U.; Eduvie, L. O.; Gefu, J. J. Ethnopharmacol. 1999, 67, 225-228. https://doi.org/10.1016/S0378-8741(98)00214-1
  6. Akinpelu, D. A. Fitoterapia 2001, 72, 286-287. https://doi.org/10.1016/S0367-326X(00)00310-5
  7. Gordon, A.; Friederich, M.; da Matta, V. M.; Herbster Moura, C. F.; Marx, F. Fruits 2012, 67, 267-276. https://doi.org/10.1051/fruits/2012023
  8. Razali, N.; Razab, R.; Junit, S. M.; Abdul-Aziz, A. Food Chem. 2008, 111, 38-44. https://doi.org/10.1016/j.foodchem.2008.03.024
  9. Santos, G. H. F.; Silva, E. B.; Silva, B. L.; Sena, K. X. F. R.; Lima, C. S. A. Rev. Bras. Farmacogn. 2011, 21, 444-449. https://doi.org/10.1590/S0102-695X2011005000045
  10. Kolaczkowski, M.; Kolaczkowska, A.; Sroda, K.; Ramalhete, C.; Michalak, K.; Mulhovo, S.; Ferreira, M. J. Mycoses 2010, 53, 305-310. https://doi.org/10.1111/j.1439-0507.2009.01711.x
  11. Abdullahi, S.; Olatunji, G. A. Journal of Science and Technology 2010, 30, 35-41.
  12. Taiwo, B. J.; Fatokun, A. A.; Olubiyi, O. O.; Bamigboye-Taiwo, O. T.; Van Heerden, F. R.; Wright, C. W. Bioorg. Med. Chem. 2017, 25, 2327-2335. https://doi.org/10.1016/j.bmc.2017.02.040
  13. Schultz, D. J.; Wickramasinghe, N. S.; Ivanova, M. M.; Isaacs, S. M.; Dougherty, S. M.; Imbert-Fernandez, Y.; Cunningham, A. R.; Chen, C.; Klinge, C. M. Mol. Cancer Ther. 2010, 9, 594-605. https://doi.org/10.1158/1535-7163.MCT-09-0978
  14. Kumar, P. P.; Paramashivappa, R.; Vithayathil, P. J.; Subba Rao, P. V.; Srinivasa Rao, A. J. Agric. Food Chem. 2002, 50, 4705-4708. https://doi.org/10.1021/jf020224w
  15. Trevisan, M. T. S.; Pfundstein, B.; Haubner, R.; Wurtele, G.; Spiegelhalder, B.; Bartsch, H.; Owen, R. W. Food Chem. Toxicol. 2006, 44, 188-197. https://doi.org/10.1016/j.fct.2005.06.012
  16. De Souza Daniel, J. F.; Fernandes Alves, C. C. F.; Grivicich, I.; Brondani, A.; De Carvalho, M. G. Indian J. Pharmacol. 2007, 39, 184-186. https://doi.org/10.4103/0253-7613.36536
  17. Alexander-Lindo, R. L.; Morrison, E. Y.; Nair, M. G. Phytother. Res. 2004, 18, 403-407. https://doi.org/10.1002/ptr.1459
  18. Murthy, S. S.; Anjaneyulu, A. S.; Row, L. R.; Pelter, A.; Ward, R. S. Planta Med. 1982, 45, 3-10. https://doi.org/10.1055/s-2007-971230
  19. De Abreu, F. P.; Dornior, M.; Dionisio, A. P.; Carail, M.; Caris-Veyrat, C.; Dhuique-Mayer, C. Food Chem. 2013, 138, 25-31. https://doi.org/10.1016/j.foodchem.2012.10.028
  20. Jose, J. K.; Kuttan, R. J. Ethnopharmacol. 2000, 72, 135-140. https://doi.org/10.1016/S0378-8741(00)00219-1
  21. Abdullahi, S.; Mangala, G. P.; Mahboob, M.; Prabhakar, P. V.; Olatunji, G. A. Nat. Prod. Res. 2021, 35, 1357-1363. https://doi.org/10.1080/14786419.2019.1650353
  22. Lee, I. K.; Kim, M. A.; Lee, S. Y.; Hong, J. K.; Lee, J. H.; Lee, K. R. Nat. Prod. Sci. 2008, 14, 100-106. https://doi.org/10.1073/pnas.0708465105
  23. Sun, C. M.; Toia, R. F. J. Nat. Prod. 1993, 56, 953-956. https://doi.org/10.1021/np50096a024
  24. Sacchi, R.; Addeo, F.; Paolillo, L. Magn. Res. Chem. 1997, 35, S133-S145. https://doi.org/10.1002/(SICI)1097-458X(199712)35:133.0.CO;2-K
  25. Ando, T.; Kusa, K.; Uchiyama, M.; Yoshida, M.; Takehashi, N. Agric. Biol. Chem. 1983, 47, 2849-2853. https://doi.org/10.1271/bbb1961.47.2849
  26. Gunstone, F. D.; Polard, M. R.; Scrimgeour, C. M.; Vedanayagam, H. S. Chem. Phys. Lipids 1977, 18, 115-129. https://doi.org/10.1016/0009-3084(77)90031-7
  27. Bus, J.; Sies, I.; Lie Ken Jie, M. S. F. Chem. Phys. Lipids. 1977, 18, 130-144. https://doi.org/10.1016/0009-3084(77)90032-9
  28. Mizushina, Y.; Nakanishi, R.; Kuriyama, I.; Kamiya, K.; Satake, T.; Shimazaki, N.; Koiwai, O.; Uchiyama, Y.; Yonezawa, Y.; Takemura, M.; Sakaguchi, K.; Yoshida, H. J. Steroid Biochem. Mol. Biol. 2006, 99, 100-107. https://doi.org/10.1016/j.jsbmb.2005.12.007
  29. Abdel-Hameed, E. S.; Bazaid, S. A.; Shohayeb, M. W.; El-Sayed, M. M., El-Wakil, E. A. Eur. J. Med. Plants 2012, 2, 93-112. https://doi.org/10.9734/EJMP/2012/1040
  30. Ata-ur-Rahman; Choudhary, M. I.; Thomsen, W. J. Bioassay Techniques for Drug Development. Informa Health care: U.S.A., 2007, p 30.