Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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E-cigarette use for smoking cessation and its regulatory trends worldwide

금연을 위한 전자담배의 사용과 세계 규제 동향

  • Received : 2022.05.20
  • Accepted : 2022.06.08
  • Published : 2022.06.30
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Abstract

E-cigarettes were considered safe at the early stage of market entry because they were thought not to contain harmful ingredients such as nicotine and because the smoke emitted was vapor. For this reason, the use of e-cigarettes as a safer alternative to tobacco cigarettes or as a smoking cessation aid has emerged. However, the study results on the effectiveness of e-cigarettes for smoking cessation are mixed. In response to the increased use of e-cigarettes, foreign countries have implemented various regulations, such as utilizing e-cigarettes for smoking cessation with a prescription in Australia; however, South Korea is still standing firm on recommending not to use e-cigarettes at all. Therefore, the effectiveness of e-cigarettes for smoking cessation and the regulatory trends of e-cigarette use overseas will be reviewed to discuss the future direction in South Korea needs to take.

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References

  1. Ministry of Health and Welfare. Types of tobacco_heated tobacco. No smoke guide. Available from https://www.nosmokeguide.go.kr/lay2/bbs/S1T33C112/H/25/view.do?article_seq=777418&tag_name=&cpage=1&rows=10&condition=&keyword=&cat=&rn=6. Accessed May 8, 2022.
  2. Ministry of Health and Welfare. Types of tobacco_e-cigarette (closed system vaporizer, CSV). No smoke guide. Available from https://www.nosmokeguide.go.kr/lay2/bbs/S1T33C112/H/25/view.do?article_seq=788617&tag_name=&cpage=1&rows=10&condition=&keyword=&cat=&rn=2. Accessed May 8, 2022.
  3. Hwang J. A qualitative study on the level of interest in heated tobacco products in South Korea: using data of Naver search trend and online news media coverage. Health and Social Welfare Review 2020;40(4):611-635. https://doi.org/10.15709/HSWR.2020.40.4.611
  4. Ministry of Health and Welfare. Types of tobacco_e-cigarette. No smoke guide. Available from https://www.nosmokeguide.go.kr/lay2/bbs/S1T33C112/H/25/view.do?article_seq=258&tag_name=&cpage=2&rows=10&condition=&keyword=&cat=&rn=15. Accessed May 8, 2022.
  5. Ministry of Health and Welfare. Strong recommendation to stop using e-cigarettes. Available from http://www.mohw.go.kr/react/al/sal0301vw.jsp?PAR_MENU_ID=04&MENU_ID=0403&CONT_SEQ=351280&page=1. Accessed May 8, 2022.
  6. Ministry of Health and Welfare. Modified Risk Tobacco Product. No smoke guide. Available from https://www.nosmokeguide.go.kr/lay2/bbs/S1T33C112/H/25/view.do?article_seq=796382&tag_name=Heat-not-burn_tobacco&cpage=1&rows=10&condition=&keyword=&cat=&rn=1. Accessed May 8, 2022.
  7. Ministry of Health and Welfare. Types of tobacco_non-nicotine ecigarette, electronic smoking craving suppressant. No smoke guide. Available from https://www.nosmokeguide.go.kr/lay2/bbs/S1T33C112/H/25/view.do?article_seq=777419&tag_name=&cpage=1&rows=10&condition=&keyword=&cat=&rn=4. Accessed May 8, 2022.
  8. Centers for Disease Control and Prevention. Heated tobacco products. Available from https://www.cdc.gov/tobacco/basic_information/heated-tobacco-products/index.html. Accessed April 27, 2022.
  9. U.S. Food & Drug Administration. How are non-combusted cigarettes, sometimes called heat-not-burn products, different from e-cigarettes and cigarettes? Available from https://www.fda.gov/tobacco-products/products-ingredients-components/how-are-noncombusted-cigarettes-sometimes-called-heat-not-burn-productsdifferent-e-cigarettes-and. Accessed April 27, 2022.
  10. World Health Organization. WHO report on the global tobacco epidemic 2021: addressing new and emerging products. Available from https://www.who.int/publications/i/item/9789240032095. Accessed April 27, 2022.
  11. Gotts JE, Jordt S-E, McConnell R, Tarran R. What are the respiratory effects of e-cigarettes? BMJ 2019;366:l5275.
  12. Wills TA, Soneji SS, Choi K, Jaspers I, Tam EK. E-cigarette use and respiratory disorders: an integrative review of converging evidence from epidemiological and laboratory studies. Eur Respir J 2021;57(1):1901815. https://doi.org/10.1183/13993003.01815-2019
  13. Skotsimara G, Antonopoulos AS, Oikonomou E, et al. Cardiovascular effects of electronic cigarettes: a systematic review and meta-analysis. Eur J Prev Cardiol 2019;26(11):1219-28. https://doi.org/10.1177/2047487319832975
  14. Kennedy CD, Schalkwyk MCI, McKee M, Pisinger C. The cardiovascular effects of electronic cigarettes: a systematic review of experimental studies. Prev Med 2019;127:105770. https://doi.org/10.1016/j.ypmed.2019.105770
  15. Tsai M, Byun MK, Shin J, Crotty Alexander LE. Effects of e-cigarettes and vaping devices on cardiac and pulmonary physiology. J Physiol 2020;598(22):5039-62. https://doi.org/10.1113/JP279754
  16. Stevens EM, Hebert ET, Tackett AP, Leavens ELS, Wagener TL. Harm perceptions of the JUUL e-cigarette in a sample of ever users. Int J Environ Res Public Health 2020;17(13):4755. https://doi.org/10.3390/ijerph17134755
  17. World Health Organization. WHO study group on tobacco product regulation: report on the scientific basis of tobacco product regulation: eighth report of a WHO study group. Available from https://www.who.int/publications/i/item/9789240022720. Accessed April 28, 2022.
  18. Wang JB, Olgin JE, Nah G, et al. Cigarette and e-cigarette dual use and risk of cardiopulmonary symptoms in the Health eHeart Study. PLoS One 2018;13(7):e0198681. https://doi.org/10.1371/journal.pone.0198681
  19. Kim CY, Paek YJ, Seo HG, et al. Dual use of electronic and conventional cigarettes is associated with higher cardiovascular risk factors in Korean men. Sci Rep 2020;10(1):5612. https://doi.org/10.1038/s41598-020-62545-3
  20. Reddy KP, Schwamm E, Kalkhoran S, Noubary F, Walensky RP, Rigotti NA. Respiratory symptom incidence among people using electronic cigarettes, combustible tobacco, or both. Am J Respir Crit Care Med 2021;204(2):231-4. https://doi.org/10.1164/rccm.202012-4441LE
  21. Goniewicz ML, Smith DM, Edwards KC, et al. Comparison of nicotine and toxicant exposure in users of electronic cigarettes and combustible cigarettes. JAMA Netw Open 2018;1(8):e185937. https://doi.org/10.1001/jamanetworkopen.2018.5937
  22. Centers for Disease Control and Prevention. Smoking & tobacco use: quick facts on the risks of e-cigarettes for kids, teens, and young adults. Available from https://www.cdc.gov/tobacco/basic_information/e-cigarettes/Quick-Facts-on-the-Risks-of-E-cigarettes-for-KidsTeens-and-Young-Adults.html. Accessed May 1, 2022.
  23. Whittington JR, Simmons PM, Phillips AM, et al. The use of electronic cigarettes in pregnancy: a review of the literature. Obstet Gynecol Surv 2018;73(9):544-9. https://doi.org/10.1097/OGX.0000000000000595
  24. Froggatt S, Reissland N, Covey J. The effects of prenatal cigarette and e-cigarette exposure on infant neurobehaviour: a comparison to a control group. EClinicalMedicine 2020;28:100602. https://doi.org/10.1016/j.eclinm.2020.100602
  25. Berry KM, Fetterman JL, Benjamin EJ, et al. Association of electronic cigarette use with subsequent initiation of tobacco cigarettes in US youths. JAMA Netw Open 2019;2(2):e187794. https://doi.org/10.1001/jamanetworkopen.2018.7794
  26. Centers for Disease Control and Prevention. Smoking & tobacco use: outbreak of lung injury associated with e-cigarette use, or vaping. Available from https://www.cdc.gov/tobacco/basic_information/e-cigarettes/severe-lung-disease.html. Accessed May 1, 2022.
  27. Hess IM, Lachireddy K, Capon A. A systematic review of the health risks from passive exposure to electronic cigarette vapour. Public Health Res Pract 2016;26(2):2621617.
  28. Korea Disease Control and Prevention Agency. Korea National Health and Nutrition Examination Survey (KNHANES), 2020. Available from https://knhanes.kdca.go.kr/knhanes/sub04/sub04_04_03.do. Accessed April 25, 2022.
  29. Korea Disease Control and Prevention Agency. Korea National Health and Nutrition Examination Survey (KNHANES), 2020. Available from https://knhanes.kdca.go.kr/knhanes/sub04/sub04_04_01.do. Accessed April 25, 2022.
  30. Korea Disease Control and Prevention Agency. Korea National Health and Nutrition Examination Survey (KNHANES) fact sheet. Available from https://knhanes.kdca.go.kr/knhanes/sub04/sub04_04_05.do. Accessed April 25, 2022.
  31. Ministry of Economy and Finance. 2021 tobacco market trend. Available from https://www.korea.kr/news/pressReleaseView.do?newsId=156493926. Accessed April 26, 2022.
  32. Korea Disease Control and Prevention Agency. Youth health behavior survey, 2020. Available from https://www.kdca.go.kr/yhs/home.jsp. Accessed April 25, 2022.
  33. Korea Disease Control and Prevention Agency. Youth health behavior survey, 2019. Available from https://www.kdca.go.kr/yhs/home.jsp. Accessed April 25, 2022.
  34. Korea Disease Control and Prevention Agency. Youth health behavior survey fact sheet. Available from https://knhanes.kdca.go.kr/knhanes/sub04/sub04_04_05.do. Accessed April 25, 2022.
  35. Korea Disease Control and Prevention Agency. Korea National Health and Nutrition Examination Survey (KNHANES) and youth health behavior survey, 2018. Available from https://knhanes.kdca.go.kr/knhanes/sub04/sub04_04_03.do. Accessed April 26, 2022.
  36. Zhu SH, Zhuang YL, Wong S, Cummins SE, Tedeschi GJ. E-cigarette use and associated changes in population smoking cessation: evidence from US current population surveys. BMJ 2017;358:j3262.
  37. Piece JP, Chen R, Kealey S, et al. Incidence of cigarette smoking relapse among individuals who switched to e-cigarettes or other tobacco products. JAMA Netw Open 2021;4(10):e2128810. https://doi.org/10.1001/jamanetworkopen.2021.28810
  38. Kasza KA, Edwards KC, Kimmel HL, et al. Association of e-cigarette use with discontinuation of cigarette smoking among adult smokers who were initially never planning to quit. JAMA Netw Open 2021;4(12):e2140880. https://doi.org/10.1001/jamanetworkopen.2021.40880
  39. Hajek P, Phillips-Waller A, Przulj D, et al. A randomized trial of e-cigarettes versus nicotine-replacement therapy. N Engl J Med 2019;380(7):629-37. https://doi.org/10.1056/NEJMoa1808779
  40. Hartmann-Boyce J, McRobbie H, Butler AR, et al. Electronic cigarettes for smoking cessation. Cochrane Database Syst Rev 2021;9(9):CD010216.
  41. Hajat C, Stein E, Selya A, Polosa R, CoEHAR study group. Analysis of common methodological flaws in the highest cited e-cigarette epidemiology research. Intern Emerg Med 2022;17(3):887-909. https://doi.org/10.1007/s11739-022-02967-1
  42. Kaplan B, Galiatsatos P, Breland A, Eissenberg T, Cohen JE. Effectiveness of ENDS, NRT and medications for smoking cessation among cigarette-only users: a longitudinal analysis of PATH study wave 3 (2015-2016) and 4 (2016-2017), adult data. Tob Control 2021;tobaccocontrol-2020-056448.
  43. Loukas A, Marti CN, Harrell MB. Electronic nicotine delivery systems use predicts transitions in cigarette smoking among young adults. Drug Alcohol Depend 2022;231:109251. https://doi.org/10.1016/j.drugalcdep.2021.109251
  44. Kalkhoran S, Glantz SA. E-cigarettes and smoking cessation in real-world and clinical settings: a systematic review and meta-analysis. Lancet Respir Med 2016;4(2):116-28. https://doi.org/10.1016/S2213-2600(15)00521-4
  45. Hedman L, Galanti MR, Ryk L, Gilljam H, Adermark L. Electronic cigarette use and smoking cessation in cohort studies and randomized trials: a systematic review and meta-analysis. Tob Prev Cessat 2021;7:62.
  46. Hanewinkel R, Niederberger K, Pedersen A, Unger JB, Galimov A. E-cigarettes and nicotine abstinence: a meta-analysis of randomised controlled trials. Eur Respir Rev 2022;31(163):210215. https://doi.org/10.1183/16000617.0215-2021
  47. Quigley JM, Walsh C, Lee C, et al. Efficacy and safety of electronic cigarettes as a smoking cessation intervention: a systematic review and network meta-analysis. Tob Prev Cessat 2021;7:69.
  48. Global tobacco control. Country laws regulating e-cigarettes. Available from https://globaltobaccocontrol.org/en/policy-scan/ecigarettes/countries. Accessed May 8, 2022.
  49. National Institute for Health and Care Excellence. Tobacco: preventing uptake, promoting quitting and treating dependence. Available from https://www.nice.org.uk/guidance/ng209/resources/tobacco-preventing-uptake-promoting-quitting-and-treatingdependence-pdf-66143723132869. Accessed May 8, 2022.
  50. Wickware C. UK medicines regulator to approve e-cigarettes for medical use. Available from https://pharmaceutical-journal.com/article/news/uk-medicines-regulator-to-approve-e-cigarettes-formedical-use#:~:text=E%2Dcigarettes%20could%20be%20prescribed,regulator%2C%20the%20government%20has%20an nounced. Accessed May 8, 2022.
  51. Wickware C. No new license applications for e-cigarettes since UK medicines regulator changed its guidance. Available from https://pharmaceutical-journal.com/article/news/no-new-applications-fore-cigarettes-since-uk-medicines-regulator-changed-its-guidance. Accessed May 8, 2022.
  52. Therapeutic Goods Administration (TGA). Nicotine vaping laws are changing. Available from https://www.tga.gov.au/node/937248. Accessed May 1, 2022.
  53. FDA. FDA permits marketing of e-cigarette products, marking first authorization of its kind by the agency. Available from https://www.fda.gov/news-events/press-announcements/fda-permitsmarketing-e-cigarette-products-marking-first-authorization-itskind-agency. Accessed May 8, 2022.
  54. U.S. Food & Drug Administration. Premarket tobacco product applications. Available from https://www.fda.gov/tobacco-products/market-and-distribute-tobacco-product/premarket-tobacco-productapplications. Accessed May 8, 2022.
  55. U.S. Food & Drug Administration. FDA issues decisions on additional e-cigarette products. Available from https://www.fda.gov/news-events/press-announcements/fda-issues-decisions-additionale-cigarette-products. Accessed May 8, 2022.
  56. Ministry of Environment. (Joint) announcement on the performance of e-cigarette safety management. Available from http://me.go.kr/home/web/board/read.do?pagerOffset=0&maxPageItems=10&maxIndexPages=10&searchKey=&searchValue=&menuId=&orgCd=&boardId=1401595&boardMasterId=1&boardCategoryId=&decorator=. Accessed May 8, 2022.
  57. Ministry of Health and Welfare. E-cigarette safety management measures. Available from http://www.mohw.go.kr/upload/viewer/skin/doc.html?fn=1571756470651_20191023000110.hwp&rs=/upload/viewer/result/202206/. Accessed June 4, 2022.
  58. Ministry of Food and Drug Safety. Joint announcement on the results of analysis of suspected harmful ingredients in domestic liquid e-cigarettes. Available from https://www.mfds.go.kr/brd/m_99/view.do?seq=43861. Accessed June 4, 2022.
  59. Korea Consumer Agency. Beware of child safety accidents caused by food and toy-shaped products. Available from https://www.pediatrics.or.kr/mail/2021/file/mail_210601_2_file.pdf. Accessed June 4, 2022.
  60. Sha A, Britton J, Bogdanovica I. Developing a novel e-cigarette regulatory and policy control scale: results from the European Union. Drugs: Education, Prevention and Policy 2021; doi: 10.1080/09687637.2021.1959520