The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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[10]-Gingerol Induces Intrinsic Apoptosis in A2058 Human Melanoma Cells

  • Guon, Tae Eun (Dept. of Food and Nutrition, Duksung Women's University) ;
  • Chung, Ha Sook (Dept. of Food and Nutrition, Duksung Women's University)
  • Received : 2022.04.08
  • Accepted : 2022.05.10
  • Published : 2022.06.30
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Abstract

The objective of the present study was to investigate the molecular mechanisms involved in the activity of [10]-gingerol using A2058 human melanoma cells. [10]-Gingerol inhibited the proliferation of A2058 cells by 50% at a concentration of 52 μM. Such inhibition was dose-dependent accompanied by morphological change indicative of apoptosis. Furthermore, flow cytometric analysis by Annexin V and PI double staining showed that [10]-gingerol increased the extent of apoptosis. Analysis of the mechanism of these events indicated that [10]-gingerol increased the ratio of Bax to Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner.

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