한국발생생물학회지:발생과생식 (Development and Reproduction)

  • 제26권4호
  • /
  • Pages.135-144
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  • 2022
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  • 2465-9525(pISSN)
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  • 2465-9541(eISSN)
한국발생생물학회 (The Korean Society of Developmental Biology)
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Lipid Polysaccharides have a Detrimental Effect on the Function of the Ovaries and Uterus in Mice through Increased Pro-Inflammatory Cytokines

  • Jihyeon Seo (Department of Bioenvironmental Technology, College of Natural Sciences, Seoul Women's University) ;
  • Jungmin Lee (Department of Bioenvironmental Technology, College of Natural Sciences, Seoul Women's University) ;
  • Sua Kim (Department of Bioenvironmental Technology, College of Natural Sciences, Seoul Women's University) ;
  • Minji Lee (Department of Bioenvironmental Technology, College of Natural Sciences, Seoul Women's University) ;
  • Hyunwon Yang (Department of Bioenvironmental Technology, College of Natural Sciences, Seoul Women's University)
  • 투고 : 2022.09.30
  • 심사 : 2022.11.18
  • 발행 : 2022.12.31
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초록

As the number of coronavirus disease 2019 (COVID-19) vaccinations increases, various side effects are being reported, and menstrual abnormalities have been reported as a side effect in women. However, it is still unclear whether the COVID-19 vaccine has detrimental effects on the female reproductive system. Therefore, we investigated the effect of excessive immune response on reproductive function by administering Lipopolysaccharides (LPS) instead of the COVID-19 vaccine. The immune response in mice was induced by injection of LPS. Mice injected with saline 5 times were used as a control group, and mice injected with LPS 5 times were used as an experimental group. Repeated administration of LPS significantly reduced the number of corpus luteum (CL). On the other hand, the injection of LPS did not affect the development of follicles leading before the CL. The expression of the apoptosis-related genes Fas and Fas-L increased in the experimental group. In addition, the expression of the inflammation-related genes increased in the experimental group. In this study, we confirmed that LPS had detrimental effects on the uterus and ovaries in mice. These results suggest that injection of LPS can cause immune reactions within the uterus and ovaries and cause hormonal changes, which can have adverse effects such as abnormal operation or bleeding of the menstrual cycle. These results are expected to help determine the cause of decreased reproductive function, infertility, or physiological disorders caused by the COVID-19 vaccine.

키워드

과제정보

This work was supported by a special research grant from Seoul Women's University (2022).

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