한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제39권3호
  • /
  • Pages.121-125
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  • 2022
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
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Spontaneous Regression of Eyelid Histiocytoma in a Maltese Dog

  • Kim, Boyun (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Lim, Jaegook (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Shim, Jae-ho (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Seo, Kangmoon (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Kang, Seonmi (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
  • 투고 : 2022.02.03
  • 심사 : 2022.05.23
  • 발행 : 2022.06.30
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초록

A 1-year-old neutered male Maltese dog was presented with a mass on the upper eyelid of the left eye (OS). A pinkish and alopecic mass was located in the nasal portion of the upper eyelid of OS. The mass was firmly attached to the eyelid and round-shaped with a diameter of 11 mm. Any spread to conjunctiva was not identified. On a cytological examination, cutaneous histiocytoma was confirmed, with the presence of small lymphocytes indicating later regression stage. The patient received no treatment and complete regression of the mass was verified 2 months later. The cytological examination was helpful for the diagnosis and staging of cutaneous histiocytoma. Canine eyelid histiocytoma can regress spontaneously, and thus medical or surgical treatment for removal should be considered carefully.

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과제정보

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2021R1I1A1A01058695).

참고문헌

  1. Angus JC, de Lorimier LP. Lymphohistiocytic neoplasms. In: Campbell KL, editor. Small animal dermatology secrets. Amsterdam: Elsevier. 2004: 425-442.
  2. Cockerell GL, Slauson DO. Patterns of lymphoid infiltrate in the canine cutaneous histiocytoma. J Comp Pathol 1979; 89: 193-203. https://doi.org/10.1016/0021-9975(79)90058-6
  3. Faller M, Lamm C, Affolter VK, Valerius K, Schwartz S, Moore PF. Retrospective characterisation of solitary cutaneous histiocytoma with lymph node metastasis in eight dogs. J Small Anim Pract 2016; 57: 548-552. https://doi.org/10.1111/jsap.12531
  4. Guvenc T, Haligur M, Orman MN, Haziroglu R. Mitosis and apoptosis in canine cutaneous histiocytoma and transmissible venereal tumour. Acta Vet Hung 2002; 50: 315-321. https://doi.org/10.1556/AVet.50.2002.3.8
  5. Kaim U, Moritz A, Failing K, Baumgartner W. The regression of a canine Langerhans cell tumour is associated with increased expression of IL-2, TNF-alpha, IFN-gamma and iNOS mRNA. Immunology 2006; 118: 472-482. https://doi.org/10.1111/j.1365-2567.2006.02394.x
  6. Maggs D, Miller P, Ofri R. Slatter's fundamentals of veterinary ophthalmology. 6th ed. St. Louis: Elsevier Health Sciences. 2018: 127-157.
  7. Moore PF. A review of histiocytic diseases of dogs and cats. Vet Pathol 2014; 51: 167-184. https://doi.org/10.1177/0300985813510413
  8. Moore PF, Schrenzel MD, Affolter VK, Olivry T, Naydan D. Canine cutaneous histiocytoma is an epidermotropic Langerhans cell histiocytosis that expresses CD1 and specific beta 2-integrin molecules. Am J Pathol 1996; 148: 1699-1708.
  9. Nowak M, Madej JA, Gotowiecka M, Kanzawa H, Dziegiel P. Inflammatory form of histiocytoma with a malignant course in a dog. A case report. Bull Vet Inst Pulawy 2009; 53: 153-157.
  10. Puff C, Risha E, Baumgartner W. Regression of canine cutaneous histiocytoma is associated with an orchestrated expression of matrix metalloproteinases. J Comp Pathol 2013; 149: 208-215. https://doi.org/10.1016/j.jcpa.2013.01.014
  11. Taylor DO, Dorn CR, Luis OH. Morphologic and biologic characteristics of the canine cutaneous histiocytoma. Cancer Res 1969; 29: 83-92.
  12. Withrow SJ. Miscellaneous tumors. In: Withrow SJ, Vail DM, Page RL, editors. Withrow and MacEwen's small animal clinical oncology. 5th ed. St. Louis: Elsevier Health Sciences. 2012: 679-715.